Protocol for the development of a repository of individual participant data from randomised controlled trials conducted in adult care homes (the Virtual International Care Homes Trials Archive (VICHTA))

Approximately 418,000 folks dwell in care homes in the UK, but accessible, sturdy data on care dwelling populations and organisation are missing. This hampers our means to plan, allocate assets or stop threat. Large randomised controlled trials (RCTs) conducted in care homes provide a potential resolution. The worth of detailed data on residents’ demographics, outcomes and contextual info captured in RCTs has but to be absolutely realised. Irrespective of the intervention examined, a lot of the trial data collected overlaps in phrases of structured assessments and descriptive info.
Given the time and prices required to prospectively accumulate data in these populations, pooling anonymised RCT data into a structured repository presents profit; secondary analyses of pooled RCT data can enhance understanding of this under-researched inhabitants and improve the future trial design. This protocol describes the creation of a project-specific repository of individual participant data (IPD) from trials conducted in care homes and subsequent enlargement into a legacy dataset for wider use, to deal with the want for correct, high-quality IPD on this susceptible inhabitants.
Informed by scoping of related literature, the principal investigators of RCTs conducted in adult care homes in the UK since 2010 will probably be invited to contribute trial IPD. Contributing trialists will type a Steering Committee who will oversee data sharing and stay gatekeepers of their very own trial’s data. IPD will probably be cleaned and standardised in session with the Steering Committee for accuracy. Planned analyses embrace a comparability of pooled IPD with level estimates from administrative sources, to evaluate generalisability of RCT data to the wider care dwelling inhabitants.
We may even establish key resident traits and outcomes from inside the trial repository, which is able to inform the development of a nationwide minimal dataset for care homes. Following challenge completion, administration will migrate to the Virtual Trials Archives, forming a legacy dataset which will probably be expanded to incorporate worldwide RCTs, and will probably be accessible to the wider analysis neighborhood for analyses. Analysis of pooled IPD has the potential to tell and direct future follow, analysis and coverage at low value, enhancing the worth of current data and lowering analysis waste. We intention to create a everlasting archive for care dwelling trial data and welcome the contribution of rising trial datasets.

OGP: A Repository of Experimentally Characterized O-Glycoproteins to Facilitate Studies on O-Glycosylation

Numerous research on most cancers, biopharmaceuticals, and medical trials have necessitated complete and exact evaluation of protein O-glycosylation. However, the lack of up to date and handy databases deters the storage of and reference to rising O-glycoprotein data. To resolve this difficulty, an O-glycoprotein repository named OGP was established in this work. It was constructed with a assortment of O-glycoprotein data from completely different sources. OGP accommodates 9354 O-glycosylation websites and 11,633 site-specific O-glycans mapping to 2133 O-glycoproteins, and it’s the largest O-glycoprotein repository to date. Based on the recorded O-glycosylation websites, an O-glycosylation web site prediction instrument was developed.

The first model of OGP repository and the web site enable customers to acquire numerous O-glycoprotein-related info, equivalent to protein accession numbers, O-glycosylation websites, glycopeptide sequences, site-specific glycan constructions, experimental strategies, and potential O-glycosylation websites. To tackle the challenges posed by large-scale development, validation, and adoption of synthetic intelligence (AI) in pathology, now we have constituted a consortium of teachers, small enterprises, and pharmaceutical corporations and proposed the BIGPICTURE challenge to the Innovative Medicines Initiative.

Our imaginative and prescient is to change into the catalyst in the digital transformation of pathology by creating the first European, ethically compliant, and quality-controlled entire slide imaging platform, in which each large-scale data and AI algorithms will exist. Our mission is to develop this platform in a sustainable and inclusive means, by connecting the neighborhood of pathologists, researchers, AI builders, sufferers, and trade events primarily based on creating worth and reciprocity in use primarily based on a neighborhood mannequin as the mechanism for making certain sustainability of the platform.

Protocol for the development of a repository of individual participant data from randomised controlled trials conducted in adult care homes (the Virtual International Care Homes Trials Archive (VICHTA))

Missense3D-DB net catalogue: an atom-based evaluation and repository of 4M human protein-coding genetic variants

The interpretation of human genetic variation is one of the biggest challenges of fashionable genetics. New approaches are urgently wanted to prioritize variants, particularly these which might be uncommon or lack a definitive medical interpretation. We examined 10,136,597 human missense genetic variants from GnomAD, ClinVar and UniProt. We had been capable of carry out large-scale atom-based mapping and phenotype interpretation of 3,960,015 of these variants onto 18,874 experimental and 84,818 in home predicted three-dimensional coordinates of the human proteome.

We show that 14% of amino acid substitutions from the GnomAD database that could possibly be structurally analysed are predicted to have an effect on protein construction (n = 568,548, of which 566,439 uncommon or extraordinarily uncommon) and will, subsequently, have a but unknown disease-causing impact. Moreover, an OGP-based web site is already accessible (http://www.oglyp.org/). The web site contains 4 specifically designed and user-friendly modules: statistical evaluation, database search, web site prediction, and data submission.

Mouse IgG3 Isotype Control Purified

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Mouse IgG3 Isotype Control Purified

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Mouse IgG3 Isotype Control (FITC)

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Mouse IgG3 Isotype Control (PE)

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Mouse IgG3 Isotype Control (APC)

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Mouse IgG3 Isotype Control (FITC)

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Mouse IgG3-Biotin conjugate (isotype control)

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20102-104-F 50 tests
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Mouse IgG3-HRP conjugate (isotype control)

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Mouse IgG3 Isotype control; Ready-To-Use

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Mouse IgG3 Control

ICIGG3A-50 100 µg
EUR 648

Mouse IgG3 Control

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Mouse IgG3 Control

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EUR 323

Mouse IgG3 Control

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Mouse IgG3 Control

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Mouse IgG3 Isotype Control DyLight® 488

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Mouse IgG3 Isotype Control DyLight® 650

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Description: Purified Mouse IgG2a Isotype Control

Mouse IgM Isotype Control

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Mouse IgG1 Isotype Control

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EUR 314
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Mouse IgG2a Isotype Control

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EUR 314
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Mouse IgG2b Isotype Control

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EUR 314
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Mouse IgM Isotype Control

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Mouse IgG1 Isotype Control

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Mouse IgG1 Isotype Control

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Mouse IgM Isotype Control

abx139003-01mg 0.1 mg
EUR 314
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Mouse IgG2a Isotype Control

abx139004-01mg 0.1 mg
EUR 314
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Mouse IgG2a Isotype Control

abx139005-01mg 0.1 mg
EUR 314
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Mouse IgG2b Isotype Control

abx139006-01mg 0.1 mg
EUR 314
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Mouse IgG1 Isotype Control

abx139008-01mg 0.1 mg
EUR 314
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Mouse IgG2a Isotype Control

abx139009-01mg 0.1 mg
EUR 314
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Mouse IgG2b Isotype Control

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EUR 314
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Mouse IgG1 Isotype Control

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EUR 411
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Mouse IgG1 Isotype Control

abx405009-05mg 0.5 mg
EUR 690
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Mouse IgG1 Isotype Control

abx405012-1mg 1 mg
EUR 1080
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Mouse IgG2a Isotype Control

abx405013-100tests 100 tests
EUR 411
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Mouse IgG2a Isotype Control

abx405015-05mg 0.5 mg
EUR 690
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Mouse IgG2a Isotype Control

abx405018-1mg 1 mg
EUR 1107
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Mouse IgG2b Isotype Control

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EUR 411
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Mouse IgG2b Isotype Control

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Mouse IgM Isotype Control

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Mouse IgG1 Isotype Control

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Mouse IgG1 Isotype Control

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Mouse IgG2a Isotype Control

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EUR 411
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Mouse IgG2a Isotype Control

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EUR 829
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Mouse IgG Isotype Control

IC002-100ul 100ul
EUR 122

Rat IgG-Biotin conjugate (isotype control) (Isotype control)

20005-B 100 ug
EUR 164

Rat IgG-FITC conjugate (isotype control) (Isotype control)

20005-F 100 ug
EUR 164

Rat IgG-HRP conjugate (isotype control) (Isotype control)

20005-HP 100 ug
EUR 164

Rat IgG-PE conjugate (isotype control) (Isotype control)

20005-PE 25 tests
EUR 202

Rabbit Isotype Control

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Rabbit Isotype Control

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EUR 199.5

Mouse IgA isotype control, purified

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EUR 164

Mouse IgG1 isotype control, purified

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EUR 141

Mouse IgG2a isotype control, purified

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Mouse IgG2b isotype control, purified

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Mouse IgM isotype control, purified

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Mouse IgE isotype control, purified

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Mouse IgG2c isotype control, purified

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Mouse IgG1 Isotype Control Purified

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Mouse IgG1 Isotype Control Purified

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Mouse IgG2a Isotype Control Purified

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Mouse IgG2a Isotype Control Purified

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Mouse IgG1 Isotype Control Purified

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Mouse IgG1 Isotype Control Purified

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Mouse IgG2b Isotype Control Purified

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Mouse IgG2b Isotype Control Purified

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Mouse IgG2a Isotype Control Purified

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Mouse IgG2a Isotype Control Purified

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Mouse IgG2b Isotype Control Purified

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Mouse IgG2b Isotype Control Purified

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Mouse IgM Isotype Control Purified

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Mouse IgM Isotype Control Purified

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Mouse IgG1 Isotype Control APC

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EUR 122

Mouse IgG1 Isotype Control APC

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Mouse IgG2b Isotype Control APC

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Mouse IgG2b Isotype Control APC

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Mouse IgG2a Isotype Control APC

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Mouse IgG2a Isotype Control APC

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Mouse IgG1 Isotype Control Biotin

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Mouse IgG1 Isotype Control Biotin

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EUR 177

Mouse IgG2b Isotype Control Biotin

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Mouse IgG2b Isotype Control Biotin

1B-692-C100 0.1 mg
EUR 177

Mouse IgG2a Isotype Control Biotin

1B-724-C025 0.025 mg
EUR 108

Mouse IgG2a Isotype Control Biotin

1B-724-C100 0.1 mg
EUR 177

Mouse IgG1 Isotype Control FITC

1F-632-C025 0.025 mg
EUR 108

Mouse IgG1 Isotype Control FITC

1F-632-C100 0.1 mg
EUR 177

Mouse IgG2b Isotype Control FITC

1F-692-C025 0.025 mg
EUR 108

Mouse IgG2b Isotype Control FITC

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EUR 177

Mouse IgG2a Isotype Control FITC

1F-724-C025 0.025 mg
EUR 108

Mouse IgG2a Isotype Control FITC

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EUR 177

Mouse IgM Isotype Control FITC

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Mouse IgM Isotype Control FITC

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Mouse IgG1 Isotype Control PE

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EUR 122

Mouse IgG1 Isotype Control PE

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Mouse IgG2b Isotype Control PE

1P-692-C025 0.025 mg
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Mouse IgG2b Isotype Control PE

1P-692-C100 0.1 mg
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Mouse IgG2a Isotype Control PE

1P-724-C025 0.025 mg
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Mouse IgG2a Isotype Control PE

1P-724-C100 0.1 mg
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Mouse IgM Isotype Control PE

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Mouse IgM Isotype Control PE

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Mouse IgG1 Isotype Control (FITC)

abx200565-100ug 100 ug
EUR 314
  • Shipped within 3-5 working days.

Mouse IgG1 Isotype Control (PE)

abx200566-50ug 50 ug
EUR 425
  • Shipped within 3-5 working days.

Mouse IgG1 Isotype Control (APC)

abx200567-50ug 50 ug
EUR 425
  • Shipped within 3-5 working days.

Mouse IgG1 Isotype Control (PerCP)

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EUR 425
  • Shipped within 3-5 working days.

Mouse IgG2a Isotype Control (FITC)

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EUR 314
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Mouse IgG2a Isotype Control (PE)

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EUR 425
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Mouse IgG2a Isotype Control (PerCP)

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Mouse IgG2b Isotype Control (FITC)

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Mouse IgG2b Isotype Control (PE)

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EUR 425
  • Shipped within 3-5 working days.

Mouse IgG2b Isotype Control (APC)

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Mouse IgG2b Isotype Control (PerCP)

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  • Shipped within 3-5 working days.

Mouse IgM Isotype Control (FITC)

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Mouse IgG2a Isotype Control (APC)

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EUR 425
  • Shipped within 5-12 working days.

Mouse IgG2a Isotype Control (Biotin)

abx139013-01mg 0.1 mg
EUR 384
  • Shipped within 5-12 working days.

Mouse IgG2a Isotype Control (FITC)

abx139014-01mg 0.1 mg
EUR 384
  • Shipped within 5-12 working days.

Mouse IgG2a Isotype Control (PE)

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  • Shipped within 5-12 working days.

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Mouse IgG2b Isotype Control (Biotin)

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EUR 384
  • Shipped within 5-12 working days.

Mouse IgG2b Isotype Control (FITC)

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  • Shipped within 5-12 working days.

Mouse IgG2b Isotype Control (PE)

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EUR 425
  • Shipped within 5-12 working days.

Mouse IgG2b Isotype Control (PerCP)

abx139021-01mg 0.1 mg
EUR 425
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Mouse IgG1 Isotype Control (APC)

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the similar is true for 19.0% (n = 6266) of variants of unknown medical significance or conflicting interpretation reported in the ClinVar database. The outcomes of the structural evaluation can be found in the devoted net catalogue Missense3D-DB. For every of the four M variants, the outcomes of the structural evaluation are introduced in a pleasant concise format that may be included in medical genetic stories. An in depth report of the structural evaluation can also be accessible for the non-experts in structural biology. Population frequency and predictions from SIFT and PolyPhen are included for a extra complete variant interpretation. This is the first large-scale atom-based structural interpretation of human genetic variation and presents geneticists and the biomedical neighborhood a new method to genetic variant interpretation.