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Protocol for the development of a repository of individual participant data from randomised controlled trials conducted in adult care homes (the Virtual International Care Homes Trials Archive (VICHTA))

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Protocol for the development of a repository of individual participant data from randomised controlled trials conducted in adult care homes (the Virtual International Care Homes Trials Archive (VICHTA))
Approximately 418,000 folks dwell in care homes in the UK, but accessible, sturdy data on care dwelling populations and organisation are missing. This hampers our means to plan, allocate assets or stop threat. Large randomised controlled trials (RCTs) conducted in care homes provide a potential resolution. The worth of detailed data on residents’ demographics, outcomes and contextual info captured in RCTs has but to be absolutely realised. Irrespective of the intervention examined, a lot of the trial data collected overlaps in phrases of structured assessments and descriptive info.
Given the time and prices required to prospectively accumulate data in these populations, pooling anonymised RCT data into a structured repository presents profit; secondary analyses of pooled RCT data can enhance understanding of this under-researched inhabitants and improve the future trial design. This protocol describes the creation of a project-specific repository of individual participant data (IPD) from trials conducted in care homes and subsequent enlargement into a legacy dataset for wider use, to deal with the want for correct, high-quality IPD on this susceptible inhabitants.
Informed by scoping of related literature, the principal investigators of RCTs conducted in adult care homes in the UK since 2010 will probably be invited to contribute trial IPD. Contributing trialists will type a Steering Committee who will oversee data sharing and stay gatekeepers of their very own trial’s data. IPD will probably be cleaned and standardised in session with the Steering Committee for accuracy. Planned analyses embrace a comparability of pooled IPD with level estimates from administrative sources, to evaluate generalisability of RCT data to the wider care dwelling inhabitants.
We may even establish key resident traits and outcomes from inside the trial repository, which is able to inform the development of a nationwide minimal dataset for care homes. Following challenge completion, administration will migrate to the Virtual Trials Archives, forming a legacy dataset which will probably be expanded to incorporate worldwide RCTs, and will probably be accessible to the wider analysis neighborhood for analyses. Analysis of pooled IPD has the potential to tell and direct future follow, analysis and coverage at low value, enhancing the worth of current data and lowering analysis waste. We intention to create a everlasting archive for care dwelling trial data and welcome the contribution of rising trial datasets.

OGP: A Repository of Experimentally Characterized O-Glycoproteins to Facilitate Studies on O-Glycosylation

Numerous research on most cancers, biopharmaceuticals, and medical trials have necessitated complete and exact evaluation of protein O-glycosylation. However, the lack of up to date and handy databases deters the storage of and reference to rising O-glycoprotein data. To resolve this difficulty, an O-glycoprotein repository named OGP was established in this work. It was constructed with a assortment of O-glycoprotein data from completely different sources. OGP accommodates 9354 O-glycosylation websites and 11,633 site-specific O-glycans mapping to 2133 O-glycoproteins, and it’s the largest O-glycoprotein repository to date. Based on the recorded O-glycosylation websites, an O-glycosylation web site prediction instrument was developed.

The first model of OGP repository and the web site enable customers to acquire numerous O-glycoprotein-related info, equivalent to protein accession numbers, O-glycosylation websites, glycopeptide sequences, site-specific glycan constructions, experimental strategies, and potential O-glycosylation websites. To tackle the challenges posed by large-scale development, validation, and adoption of synthetic intelligence (AI) in pathology, now we have constituted a consortium of teachers, small enterprises, and pharmaceutical corporations and proposed the BIGPICTURE challenge to the Innovative Medicines Initiative.

Our imaginative and prescient is to change into the catalyst in the digital transformation of pathology by creating the first European, ethically compliant, and quality-controlled entire slide imaging platform, in which each large-scale data and AI algorithms will exist. Our mission is to develop this platform in a sustainable and inclusive means, by connecting the neighborhood of pathologists, researchers, AI builders, sufferers, and trade events primarily based on creating worth and reciprocity in use primarily based on a neighborhood mannequin as the mechanism for making certain sustainability of the platform.

Protocol for the development of a repository of individual participant data from randomised controlled trials conducted in adult care homes (the Virtual International Care Homes Trials Archive (VICHTA))

Missense3D-DB net catalogue: an atom-based evaluation and repository of 4M human protein-coding genetic variants

The interpretation of human genetic variation is one of the biggest challenges of fashionable genetics. New approaches are urgently wanted to prioritize variants, particularly these which might be uncommon or lack a definitive medical interpretation. We examined 10,136,597 human missense genetic variants from GnomAD, ClinVar and UniProt. We had been capable of carry out large-scale atom-based mapping and phenotype interpretation of 3,960,015 of these variants onto 18,874 experimental and 84,818 in home predicted three-dimensional coordinates of the human proteome.

We show that 14% of amino acid substitutions from the GnomAD database that could possibly be structurally analysed are predicted to have an effect on protein construction (n = 568,548, of which 566,439 uncommon or extraordinarily uncommon) and will, subsequently, have a but unknown disease-causing impact. Moreover, an OGP-based web site is already accessible (http://www.oglyp.org/). The web site contains 4 specifically designed and user-friendly modules: statistical evaluation, database search, web site prediction, and data submission.

Mouse IgG3 Isotype Control (PE)
abx200589-50ug 50 ug
EUR 606

Mouse IgG3 Isotype Control (APC)
abx200590-100ug 100 ug
EUR 732

Mouse IgG3 Isotype Control (PerCP)
abx200591-100ug 100 ug
EUR 732

Mouse IgG3 isotype control, purified
20102-104 100 ug
EUR 141

Mouse IgG3 Isotype control; Concentrate
NG908C 1 ml
EUR 357

Mouse IgG3 Isotype Control (CF-Blue)
abx200592-100ug 100 ug
EUR 481

Mouse IgG3 Isotype Control (OC-515)
abx200593-100ug 100 ug
EUR 606

Mouse IgG3-Biotin conjugate (isotype control)
20102-104-B 50 Tests
EUR 164

Mouse IgG3-FITC conjugate (isotype control)
20102-104-F 50 tests
EUR 164

Mouse IgG3-HRP conjugate (isotype control)
20102-104-HP 50 Tests
EUR 164

Mouse IgG3-PE conjugate (isotype control)
20102-104-PE 50 Tests
EUR 202

Mouse IgG3-PE-Cy5 conjugate (isotype control)
20102-104-PC5 50 Tests
EUR 225

Mouse IgG3 Isotype control; Ready-To-Use
NG908 7 ml
EUR 334

Mouse IgG3 Control
ICIGG3A-50 100 µg
EUR 648

Mouse IgG3 Control
ICIGG3CFB-100 100 µg
EUR 388

Mouse IgG3 Control
ICIGG3F-100 100 µg
EUR 323

Mouse IgG3 Control
ICIGG3PE-50 50 µg
EUR 518

Mouse IgG3 Control
ICIGG3PU-100 100 µg
EUR 323

Mouse IgG3 Isotype Control DyLight® 488
L4-459-C100 0.1 mg
EUR 213

Mouse IgG3 Isotype Control DyLight® 650
L6-459-C100 0.1 mg
EUR 213

Mouse IgM Isotype Control
abx020500-02mg 0.2 mg
EUR 439

Mouse IgG1 Isotype Control
abx405007-01mg 0.1 mg
EUR 411

Mouse IgG1 Isotype Control
abx405009-05mg 0.5 mg
EUR 690

Mouse IgG1 Isotype Control
abx405012-1mg 1 mg
EUR 1080

Mouse IgG2a Isotype Control
abx405013-100tests 100 tests
EUR 411

Mouse IgG2a Isotype Control
abx405015-05mg 0.5 mg
EUR 690

Mouse IgG2a Isotype Control
abx405018-1mg 1 mg
EUR 1107

Mouse IgG2b Isotype Control
abx405056-100tests 100 tests
EUR 411

Mouse IgG2b Isotype Control
abx405061-1mg 1 mg
EUR 1080

Mouse IgM Isotype Control
abx405062-100tests 100 tests
EUR 411

Mouse IgG1 Isotype Control
abx405064-100tests 100 tests
EUR 411

Mouse IgG1 Isotype Control
abx405067-05mg 0.5 mg
EUR 829

Mouse IgG2a Isotype Control
abx405070-100tests 100 tests
EUR 411

Mouse IgG2a Isotype Control
abx405073-05mg 0.5 mg
EUR 829

Mouse IgG1 Isotype Control
abx200564-100ug 100 ug
EUR 314

Mouse IgG2a Isotype Control
abx200572-100ug 100 ug
EUR 314

Mouse IgG2b Isotype Control
abx200580-100ug 100 ug
EUR 314

Mouse IgM Isotype Control
abx200594-100ug 100 ug
EUR 314

Mouse IgG1 Isotype Control
abx139001-01mg 0.1 mg
EUR 314

Mouse IgG1 Isotype Control
abx139002-01mg 0.1 mg
EUR 314

Mouse IgM Isotype Control
abx139003-01mg 0.1 mg
EUR 314

Mouse IgG2a Isotype Control
abx139004-01mg 0.1 mg
EUR 314

Mouse IgG1 Isotype Control
abx139008-01mg 0.1 mg
EUR 314

Mouse IgG2a Isotype Control
abx139005-01mg 0.1 mg
EUR 314

Mouse IgG2b Isotype Control
abx139006-01mg 0.1 mg
EUR 314

Mouse IgG2a Isotype Control
abx139009-01mg 0.1 mg
EUR 314

Mouse IgG2b Isotype Control
abx139011-01mg 0.1 mg
EUR 314

Mouse IgG Isotype Control
IC002-100ul 100ul
EUR 122

Mouse IgG2a Isotype Control
10R-I117d 1 mg
EUR 553
Description: Purified Mouse IgG2a Isotype Control

Rat IgG-Biotin conjugate (isotype control) (Isotype control)
20005-B 100 ug
EUR 164

Rat IgG-FITC conjugate (isotype control) (Isotype control)
20005-F 100 ug
EUR 164

Rat IgG-HRP conjugate (isotype control) (Isotype control)
20005-HP 100 ug
EUR 164

Rat IgG-PE conjugate (isotype control) (Isotype control)
20005-PE 25 tests
EUR 202

Rabbit Isotype Control
abx200646-100ug 100 ug
EUR 328

Rabbit Isotype Control
IMN-001 100 µg
EUR 199.5

Mouse IgG1 Isotype Control PerCP
PC-632-C025 0.025 mg
EUR 136

Mouse IgG1 Isotype Control PerCP
PC-632-C100 0.1 mg
EUR 231

Mouse IgG2b Isotype Control PerCP
PC-692-C025 0.025 mg
EUR 122

Mouse IgG2b Isotype Control PerCP
PC-692-C100 0.1 mg
EUR 204

Mouse IgG2a Isotype Control PerCP
PC-724-C025 0.025 mg
EUR 122

Mouse IgG2a Isotype Control PerCP
PC-724-C100 0.1 mg
EUR 204

Mouse IgG1 Isotype Control APC
1A-632-C025 0.025 mg
EUR 122

Mouse IgG1 Isotype Control APC
1A-632-C100 0.1 mg
EUR 204

Mouse IgG2b Isotype Control APC
1A-692-C025 0.025 mg
EUR 122

Mouse IgG2b Isotype Control APC
1A-692-C100 0.1 mg
EUR 204

Mouse IgG2a Isotype Control APC
1A-724-C025 0.025 mg
EUR 122

Mouse IgG2a Isotype Control APC
1A-724-C100 0.1 mg
EUR 204

Mouse IgG1 Isotype Control Biotin
1B-632-C025 0.025 mg
EUR 108

Mouse IgG1 Isotype Control Biotin
1B-632-C100 0.1 mg
EUR 177

Mouse IgG2b Isotype Control Biotin
1B-692-C025 0.025 mg
EUR 108

Mouse IgG2b Isotype Control Biotin
1B-692-C100 0.1 mg
EUR 177

Mouse IgG2a Isotype Control Biotin
1B-724-C025 0.025 mg
EUR 108

Mouse IgG2a Isotype Control Biotin
1B-724-C100 0.1 mg
EUR 177

Mouse IgG1 Isotype Control FITC
1F-632-C025 0.025 mg
EUR 108

Mouse IgG1 Isotype Control FITC
1F-632-C100 0.1 mg
EUR 177

Mouse IgG2b Isotype Control FITC
1F-692-C025 0.025 mg
EUR 108

Mouse IgG2b Isotype Control FITC
1F-692-C100 0.1 mg
EUR 177

Mouse IgG2a Isotype Control FITC
1F-724-C025 0.025 mg
EUR 108

Mouse IgG2a Isotype Control FITC
1F-724-C100 0.1 mg
EUR 177

Mouse IgM Isotype Control FITC
1F-803-C025 0.025 mg
EUR 108

Mouse IgM Isotype Control FITC
1F-803-C100 0.1 mg
EUR 177

Mouse IgG1 Isotype Control PE
1P-632-C025 0.025 mg
EUR 122

Mouse IgG1 Isotype Control PE
1P-632-C100 0.1 mg
EUR 204

Mouse IgG2b Isotype Control PE
1P-692-C025 0.025 mg
EUR 122

Mouse IgG2b Isotype Control PE
1P-692-C100 0.1 mg
EUR 204

Mouse IgG2a Isotype Control PE
1P-724-C025 0.025 mg
EUR 122

Mouse IgG2a Isotype Control PE
1P-724-C100 0.1 mg
EUR 204

Mouse IgM Isotype Control PE
1P-803-C025 0.025 mg
EUR 122

Mouse IgM Isotype Control PE
1P-803-C100 0.1 mg
EUR 204

Mouse IgG1 Isotype Control Purified
11-457-C025 0.025 mg
EUR 88

Mouse IgG1 Isotype Control Purified
11-457-C100 0.1 mg
EUR 136

Mouse IgG2a Isotype Control Purified
11-458-C025 0.025 mg
EUR 88

Mouse IgG2a Isotype Control Purified
11-458-C100 0.1 mg
EUR 136

Mouse IgG1 Isotype Control Purified
11-632-C025 0.025 mg
EUR 87

Mouse IgG1 Isotype Control Purified
11-632-C100 0.1 mg
EUR 136

Mouse IgG2b Isotype Control Purified
11-692-C025 0.025 mg
EUR 88

Mouse IgG2b Isotype Control Purified
11-692-C100 0.1 mg
EUR 136

Mouse IgG2a Isotype Control Purified
11-724-C025 0.025 mg
EUR 88

Mouse IgG2a Isotype Control Purified
11-724-C100 0.1 mg
EUR 136

Mouse IgG2b Isotype Control Purified
11-801-C025 0.025 mg
EUR 88

Mouse IgG2b Isotype Control Purified
11-801-C100 0.1 mg
EUR 136

Mouse IgM Isotype Control Purified
11-803-C025 0.025 mg
EUR 87

Mouse IgM Isotype Control Purified
11-803-C100 0.1 mg
EUR 136

Mouse IgG1 Isotype Control (Biotin)
abx405008-01mg 0.1 mg
EUR 509

Mouse IgG1 Isotype Control (FITC)
abx405010-01mg 0.1 mg
EUR 509

Mouse IgG1 Isotype Control (RPE)
abx405011-100tests 100 tests
EUR 634

Mouse IgG2a Isotype Control (Biotin)
abx405014-01mg 0.1 mg
EUR 411

Mouse IgG2a Isotype Control (FITC)
abx405016-01mg 0.1 mg
EUR 509

Mouse IgG2a Isotype Control (RPE)
abx405017-100tests 100 tests
EUR 634

Mouse IgG2b Isotype Control (APC)
abx405057-100tests 100 tests
EUR 481

Mouse IgG2b Isotype Control (Biotin)
abx405058-100tests 100 tests
EUR 411

Mouse IgG2b Isotype Control (FITC)
abx405059-100tests 100 tests
EUR 411

Mouse IgG2b Isotype Control (RPE)
abx405060-100tests 100 tests
EUR 467

Mouse IgM Isotype Control (FITC)
abx405063-01mg 0.1 mg
EUR 411

Mouse IgG1 Isotype Control (APC)
abx405065-100tests 100 tests
EUR 411

Mouse IgG1 Isotype Control (Biotin)
abx405066-100tests 100 tests
EUR 411

Mouse IgG1 Isotype Control (FITC)
abx405068-100tests 100 tests
EUR 411

Mouse IgG1 Isotype Control (RPE)
abx405069-100tests 100 tests
EUR 467

Mouse IgG2a Isotype Control (APC)
abx405071-100tests 100 tests
EUR 425

Mouse IgG2a Isotype Control (Biotin)
abx405072-100tests 100 tests
EUR 411

Mouse IgG2a Isotype Control (FITC)
abx405074-100tests 100 tests
EUR 411

Mouse IgG2a Isotype Control (RPE)
abx405075-100tests 100 tests
EUR 467

Mouse IgG1 Isotype Control (FITC)
abx200565-100ug 100 ug
EUR 314

Mouse IgG1 Isotype Control (PE)
abx200566-50ug 50 ug
EUR 425

Mouse IgG1 Isotype Control (APC)
abx200567-50ug 50 ug
EUR 425

Mouse IgG1 Isotype Control (PerCP)
abx200568-100ug 100 ug
EUR 425

Mouse IgG2a Isotype Control (FITC)
abx200573-100ug 100 ug
EUR 314

Mouse IgG2a Isotype Control (PE)
abx200574-50ug 50 ug
EUR 425

Mouse IgG2a Isotype Control (APC)
abx200575-50ug 50 ug
EUR 425

Mouse IgG2a Isotype Control (PerCP)
abx200576-100ug 100 ug
EUR 425

Mouse IgG2b Isotype Control (FITC)
abx200581-100ug 100 ug
EUR 314

Mouse IgG2b Isotype Control (PE)
abx200582-50ug 50 ug
EUR 425

the similar is true for 19.0% (n = 6266) of variants of unknown medical significance or conflicting interpretation reported in the ClinVar database. The outcomes of the structural evaluation can be found in the devoted net catalogue Missense3D-DB. For every of the four M variants, the outcomes of the structural evaluation are introduced in a pleasant concise format that may be included in medical genetic stories. An in depth report of the structural evaluation can also be accessible for the non-experts in structural biology. Population frequency and predictions from SIFT and PolyPhen are included for a extra complete variant interpretation. This is the first large-scale atom-based structural interpretation of human genetic variation and presents geneticists and the biomedical neighborhood a new method to genetic variant interpretation.