OGP: A Repository of Experimentally Characterized O-Glycoproteins to Facilitate Studies on O-Glycosylation
Numerous research on most cancers, biopharmaceuticals, and medical trials have necessitated complete and exact evaluation of protein O-glycosylation. However, the lack of up to date and handy databases deters the storage of and reference to rising O-glycoprotein data. To resolve this difficulty, an O-glycoprotein repository named OGP was established in this work. It was constructed with a assortment of O-glycoprotein data from completely different sources. OGP accommodates 9354 O-glycosylation websites and 11,633 site-specific O-glycans mapping to 2133 O-glycoproteins, and it’s the largest O-glycoprotein repository to date. Based on the recorded O-glycosylation websites, an O-glycosylation web site prediction instrument was developed.
The first model of OGP repository and the web site enable customers to acquire numerous O-glycoprotein-related info, equivalent to protein accession numbers, O-glycosylation websites, glycopeptide sequences, site-specific glycan constructions, experimental strategies, and potential O-glycosylation websites. To tackle the challenges posed by large-scale development, validation, and adoption of synthetic intelligence (AI) in pathology, now we have constituted a consortium of teachers, small enterprises, and pharmaceutical corporations and proposed the BIGPICTURE challenge to the Innovative Medicines Initiative.
Our imaginative and prescient is to change into the catalyst in the digital transformation of pathology by creating the first European, ethically compliant, and quality-controlled entire slide imaging platform, in which each large-scale data and AI algorithms will exist. Our mission is to develop this platform in a sustainable and inclusive means, by connecting the neighborhood of pathologists, researchers, AI builders, sufferers, and trade events primarily based on creating worth and reciprocity in use primarily based on a neighborhood mannequin as the mechanism for making certain sustainability of the platform.

Missense3D-DB net catalogue: an atom-based evaluation and repository of 4M human protein-coding genetic variants
The interpretation of human genetic variation is one of the biggest challenges of fashionable genetics. New approaches are urgently wanted to prioritize variants, particularly these which might be uncommon or lack a definitive medical interpretation. We examined 10,136,597 human missense genetic variants from GnomAD, ClinVar and UniProt. We had been capable of carry out large-scale atom-based mapping and phenotype interpretation of 3,960,015 of these variants onto 18,874 experimental and 84,818 in home predicted three-dimensional coordinates of the human proteome.
We show that 14% of amino acid substitutions from the GnomAD database that could possibly be structurally analysed are predicted to have an effect on protein construction (n = 568,548, of which 566,439 uncommon or extraordinarily uncommon) and will, subsequently, have a but unknown disease-causing impact. Moreover, an OGP-based web site is already accessible (http://www.oglyp.org/). The web site contains 4 specifically designed and user-friendly modules: statistical evaluation, database search, web site prediction, and data submission.
Mouse IgG3 Isotype Control (PE) |
abx200589-50ug |
Abbexa |
50 ug |
EUR 606 |
|
Mouse IgG3 Isotype Control (APC) |
abx200590-100ug |
Abbexa |
100 ug |
EUR 732 |
|
Mouse IgG3 Isotype Control (PerCP) |
abx200591-100ug |
Abbexa |
100 ug |
EUR 732 |
|
Mouse IgG3 Isotype control; Concentrate |
NG908C |
Innovex |
1 ml |
EUR 357 |
Mouse IgG3 Isotype Control (CF-Blue) |
abx200592-100ug |
Abbexa |
100 ug |
EUR 481 |
|
Mouse IgG3 Isotype Control (OC-515) |
abx200593-100ug |
Abbexa |
100 ug |
EUR 606 |
|
Mouse IgG3-Biotin conjugate (isotype control) |
20102-104-B |
Alpha Diagnostics |
50 Tests |
EUR 164 |
Mouse IgG3-FITC conjugate (isotype control) |
20102-104-F |
Alpha Diagnostics |
50 tests |
EUR 164 |
Mouse IgG3-HRP conjugate (isotype control) |
20102-104-HP |
Alpha Diagnostics |
50 Tests |
EUR 164 |
Mouse IgG3-PE conjugate (isotype control) |
20102-104-PE |
Alpha Diagnostics |
50 Tests |
EUR 202 |
Mouse IgG3-PE-Cy5 conjugate (isotype control) |
20102-104-PC5 |
Alpha Diagnostics |
50 Tests |
EUR 225 |
Mouse IgG3 Isotype control; Ready-To-Use |
NG908 |
Innovex |
7 ml |
EUR 334 |
Mouse IgG3 Control |
ICIGG3A-50 |
ImmunoStep |
100 µg |
EUR 648 |
Mouse IgG3 Control |
ICIGG3CFB-100 |
ImmunoStep |
100 µg |
EUR 388 |
Mouse IgG3 Control |
ICIGG3F-100 |
ImmunoStep |
100 µg |
EUR 323 |
Mouse IgG3 Control |
ICIGG3PE-50 |
ImmunoStep |
50 µg |
EUR 518 |
Mouse IgG3 Control |
ICIGG3PU-100 |
ImmunoStep |
100 µg |
EUR 323 |
Mouse IgG3 Isotype Control DyLight® 488 |
L4-459-C100 |
ExBio |
0.1 mg |
EUR 213 |
Mouse IgG3 Isotype Control DyLight® 650 |
L6-459-C100 |
ExBio |
0.1 mg |
EUR 213 |
Mouse IgM Isotype Control |
abx020500-02mg |
Abbexa |
0.2 mg |
EUR 439 |
|
Mouse IgG1 Isotype Control |
abx405007-01mg |
Abbexa |
0.1 mg |
EUR 411 |
|
Mouse IgG1 Isotype Control |
abx405009-05mg |
Abbexa |
0.5 mg |
EUR 690 |
|
Mouse IgG1 Isotype Control |
abx405012-1mg |
Abbexa |
1 mg |
EUR 1080 |
|
Mouse IgG2a Isotype Control |
abx405013-100tests |
Abbexa |
100 tests |
EUR 411 |
|
Mouse IgG2a Isotype Control |
abx405015-05mg |
Abbexa |
0.5 mg |
EUR 690 |
|
Mouse IgG2a Isotype Control |
abx405018-1mg |
Abbexa |
1 mg |
EUR 1107 |
|
Mouse IgG2b Isotype Control |
abx405056-100tests |
Abbexa |
100 tests |
EUR 411 |
|
Mouse IgG2b Isotype Control |
abx405061-1mg |
Abbexa |
1 mg |
EUR 1080 |
|
Mouse IgM Isotype Control |
abx405062-100tests |
Abbexa |
100 tests |
EUR 411 |
|
Mouse IgG1 Isotype Control |
abx405064-100tests |
Abbexa |
100 tests |
EUR 411 |
|
Mouse IgG1 Isotype Control |
abx405067-05mg |
Abbexa |
0.5 mg |
EUR 829 |
|
Mouse IgG2a Isotype Control |
abx405070-100tests |
Abbexa |
100 tests |
EUR 411 |
|
Mouse IgG2a Isotype Control |
abx405073-05mg |
Abbexa |
0.5 mg |
EUR 829 |
|
Mouse IgG1 Isotype Control |
abx200564-100ug |
Abbexa |
100 ug |
EUR 314 |
|
Mouse IgG2a Isotype Control |
abx200572-100ug |
Abbexa |
100 ug |
EUR 314 |
|
Mouse IgG2b Isotype Control |
abx200580-100ug |
Abbexa |
100 ug |
EUR 314 |
|
Mouse IgM Isotype Control |
abx200594-100ug |
Abbexa |
100 ug |
EUR 314 |
|
Mouse IgG1 Isotype Control |
abx139001-01mg |
Abbexa |
0.1 mg |
EUR 314 |
|
Mouse IgG1 Isotype Control |
abx139002-01mg |
Abbexa |
0.1 mg |
EUR 314 |
|
Mouse IgM Isotype Control |
abx139003-01mg |
Abbexa |
0.1 mg |
EUR 314 |
|
Mouse IgG2a Isotype Control |
abx139004-01mg |
Abbexa |
0.1 mg |
EUR 314 |
|
Mouse IgG1 Isotype Control |
abx139008-01mg |
Abbexa |
0.1 mg |
EUR 314 |
|
Mouse IgG2a Isotype Control |
abx139005-01mg |
Abbexa |
0.1 mg |
EUR 314 |
|
Mouse IgG2b Isotype Control |
abx139006-01mg |
Abbexa |
0.1 mg |
EUR 314 |
|
Mouse IgG2a Isotype Control |
abx139009-01mg |
Abbexa |
0.1 mg |
EUR 314 |
|
Mouse IgG2b Isotype Control |
abx139011-01mg |
Abbexa |
0.1 mg |
EUR 314 |
|
Mouse IgG Isotype Control |
IC002-100ul |
SAB |
100ul |
EUR 122 |
Mouse IgG2a Isotype Control |
10R-I117d |
Fitzgerald |
1 mg |
EUR 553 |
Description: Purified Mouse IgG2a Isotype Control |
Rat IgG-Biotin conjugate (isotype control) (Isotype control) |
20005-B |
Alpha Diagnostics |
100 ug |
EUR 164 |
Rat IgG-FITC conjugate (isotype control) (Isotype control) |
20005-F |
Alpha Diagnostics |
100 ug |
EUR 164 |
Rat IgG-HRP conjugate (isotype control) (Isotype control) |
20005-HP |
Alpha Diagnostics |
100 ug |
EUR 164 |
Rat IgG-PE conjugate (isotype control) (Isotype control) |
20005-PE |
Alpha Diagnostics |
25 tests |
EUR 202 |
Rabbit Isotype Control |
abx200646-100ug |
Abbexa |
100 ug |
EUR 328 |
|
Rabbit Isotype Control |
IMN-001 |
ImmunoStep |
100 µg |
EUR 199.5 |
Mouse IgG1 Isotype Control PerCP |
PC-632-C025 |
ExBio |
0.025 mg |
EUR 136 |
Mouse IgG1 Isotype Control PerCP |
PC-632-C100 |
ExBio |
0.1 mg |
EUR 231 |
Mouse IgG2b Isotype Control PerCP |
PC-692-C025 |
ExBio |
0.025 mg |
EUR 122 |
Mouse IgG2b Isotype Control PerCP |
PC-692-C100 |
ExBio |
0.1 mg |
EUR 204 |
Mouse IgG2a Isotype Control PerCP |
PC-724-C025 |
ExBio |
0.025 mg |
EUR 122 |
Mouse IgG2a Isotype Control PerCP |
PC-724-C100 |
ExBio |
0.1 mg |
EUR 204 |
Mouse IgG1 Isotype Control APC |
1A-632-C025 |
ExBio |
0.025 mg |
EUR 122 |
Mouse IgG1 Isotype Control APC |
1A-632-C100 |
ExBio |
0.1 mg |
EUR 204 |
Mouse IgG2b Isotype Control APC |
1A-692-C025 |
ExBio |
0.025 mg |
EUR 122 |
Mouse IgG2b Isotype Control APC |
1A-692-C100 |
ExBio |
0.1 mg |
EUR 204 |
Mouse IgG2a Isotype Control APC |
1A-724-C025 |
ExBio |
0.025 mg |
EUR 122 |
Mouse IgG2a Isotype Control APC |
1A-724-C100 |
ExBio |
0.1 mg |
EUR 204 |
Mouse IgG1 Isotype Control Biotin |
1B-632-C025 |
ExBio |
0.025 mg |
EUR 108 |
Mouse IgG1 Isotype Control Biotin |
1B-632-C100 |
ExBio |
0.1 mg |
EUR 177 |
Mouse IgG2b Isotype Control Biotin |
1B-692-C025 |
ExBio |
0.025 mg |
EUR 108 |
Mouse IgG2b Isotype Control Biotin |
1B-692-C100 |
ExBio |
0.1 mg |
EUR 177 |
Mouse IgG2a Isotype Control Biotin |
1B-724-C025 |
ExBio |
0.025 mg |
EUR 108 |
Mouse IgG2a Isotype Control Biotin |
1B-724-C100 |
ExBio |
0.1 mg |
EUR 177 |
Mouse IgG1 Isotype Control FITC |
1F-632-C025 |
ExBio |
0.025 mg |
EUR 108 |
Mouse IgG1 Isotype Control FITC |
1F-632-C100 |
ExBio |
0.1 mg |
EUR 177 |
Mouse IgG2b Isotype Control FITC |
1F-692-C025 |
ExBio |
0.025 mg |
EUR 108 |
Mouse IgG2b Isotype Control FITC |
1F-692-C100 |
ExBio |
0.1 mg |
EUR 177 |
Mouse IgG2a Isotype Control FITC |
1F-724-C025 |
ExBio |
0.025 mg |
EUR 108 |
Mouse IgG2a Isotype Control FITC |
1F-724-C100 |
ExBio |
0.1 mg |
EUR 177 |
Mouse IgM Isotype Control FITC |
1F-803-C025 |
ExBio |
0.025 mg |
EUR 108 |
Mouse IgM Isotype Control FITC |
1F-803-C100 |
ExBio |
0.1 mg |
EUR 177 |
Mouse IgG1 Isotype Control PE |
1P-632-C025 |
ExBio |
0.025 mg |
EUR 122 |
Mouse IgG1 Isotype Control PE |
1P-632-C100 |
ExBio |
0.1 mg |
EUR 204 |
Mouse IgG2b Isotype Control PE |
1P-692-C025 |
ExBio |
0.025 mg |
EUR 122 |
Mouse IgG2b Isotype Control PE |
1P-692-C100 |
ExBio |
0.1 mg |
EUR 204 |
Mouse IgG2a Isotype Control PE |
1P-724-C025 |
ExBio |
0.025 mg |
EUR 122 |
Mouse IgG2a Isotype Control PE |
1P-724-C100 |
ExBio |
0.1 mg |
EUR 204 |
Mouse IgM Isotype Control PE |
1P-803-C025 |
ExBio |
0.025 mg |
EUR 122 |
Mouse IgM Isotype Control PE |
1P-803-C100 |
ExBio |
0.1 mg |
EUR 204 |
Mouse IgG1 Isotype Control Purified |
11-457-C025 |
ExBio |
0.025 mg |
EUR 88 |
Mouse IgG1 Isotype Control Purified |
11-457-C100 |
ExBio |
0.1 mg |
EUR 136 |
Mouse IgG2a Isotype Control Purified |
11-458-C025 |
ExBio |
0.025 mg |
EUR 88 |
Mouse IgG2a Isotype Control Purified |
11-458-C100 |
ExBio |
0.1 mg |
EUR 136 |
Mouse IgG1 Isotype Control Purified |
11-632-C025 |
ExBio |
0.025 mg |
EUR 87 |
Mouse IgG1 Isotype Control Purified |
11-632-C100 |
ExBio |
0.1 mg |
EUR 136 |
Mouse IgG2b Isotype Control Purified |
11-692-C025 |
ExBio |
0.025 mg |
EUR 88 |
Mouse IgG2b Isotype Control Purified |
11-692-C100 |
ExBio |
0.1 mg |
EUR 136 |
Mouse IgG2a Isotype Control Purified |
11-724-C025 |
ExBio |
0.025 mg |
EUR 88 |
Mouse IgG2a Isotype Control Purified |
11-724-C100 |
ExBio |
0.1 mg |
EUR 136 |
Mouse IgG2b Isotype Control Purified |
11-801-C025 |
ExBio |
0.025 mg |
EUR 88 |
Mouse IgG2b Isotype Control Purified |
11-801-C100 |
ExBio |
0.1 mg |
EUR 136 |
Mouse IgM Isotype Control Purified |
11-803-C025 |
ExBio |
0.025 mg |
EUR 87 |
Mouse IgM Isotype Control Purified |
11-803-C100 |
ExBio |
0.1 mg |
EUR 136 |
Mouse IgG1 Isotype Control (Biotin) |
abx405008-01mg |
Abbexa |
0.1 mg |
EUR 509 |
|
Mouse IgG1 Isotype Control (FITC) |
abx405010-01mg |
Abbexa |
0.1 mg |
EUR 509 |
|
Mouse IgG1 Isotype Control (RPE) |
abx405011-100tests |
Abbexa |
100 tests |
EUR 634 |
|
Mouse IgG2a Isotype Control (Biotin) |
abx405014-01mg |
Abbexa |
0.1 mg |
EUR 411 |
|
Mouse IgG2a Isotype Control (FITC) |
abx405016-01mg |
Abbexa |
0.1 mg |
EUR 509 |
|
Mouse IgG2a Isotype Control (RPE) |
abx405017-100tests |
Abbexa |
100 tests |
EUR 634 |
|
Mouse IgG2b Isotype Control (APC) |
abx405057-100tests |
Abbexa |
100 tests |
EUR 481 |
|
Mouse IgG2b Isotype Control (Biotin) |
abx405058-100tests |
Abbexa |
100 tests |
EUR 411 |
|
Mouse IgG2b Isotype Control (FITC) |
abx405059-100tests |
Abbexa |
100 tests |
EUR 411 |
|
Mouse IgG2b Isotype Control (RPE) |
abx405060-100tests |
Abbexa |
100 tests |
EUR 467 |
|
Mouse IgM Isotype Control (FITC) |
abx405063-01mg |
Abbexa |
0.1 mg |
EUR 411 |
|
Mouse IgG1 Isotype Control (APC) |
abx405065-100tests |
Abbexa |
100 tests |
EUR 411 |
|
Mouse IgG1 Isotype Control (Biotin) |
abx405066-100tests |
Abbexa |
100 tests |
EUR 411 |
|
Mouse IgG1 Isotype Control (FITC) |
abx405068-100tests |
Abbexa |
100 tests |
EUR 411 |
|
Mouse IgG1 Isotype Control (RPE) |
abx405069-100tests |
Abbexa |
100 tests |
EUR 467 |
|
Mouse IgG2a Isotype Control (APC) |
abx405071-100tests |
Abbexa |
100 tests |
EUR 425 |
|
Mouse IgG2a Isotype Control (Biotin) |
abx405072-100tests |
Abbexa |
100 tests |
EUR 411 |
|
Mouse IgG2a Isotype Control (FITC) |
abx405074-100tests |
Abbexa |
100 tests |
EUR 411 |
|
Mouse IgG2a Isotype Control (RPE) |
abx405075-100tests |
Abbexa |
100 tests |
EUR 467 |
|
Mouse IgG1 Isotype Control (FITC) |
abx200565-100ug |
Abbexa |
100 ug |
EUR 314 |
|
Mouse IgG1 Isotype Control (PE) |
abx200566-50ug |
Abbexa |
50 ug |
EUR 425 |
|
Mouse IgG1 Isotype Control (APC) |
abx200567-50ug |
Abbexa |
50 ug |
EUR 425 |
|
Mouse IgG1 Isotype Control (PerCP) |
abx200568-100ug |
Abbexa |
100 ug |
EUR 425 |
|
Mouse IgG2a Isotype Control (FITC) |
abx200573-100ug |
Abbexa |
100 ug |
EUR 314 |
|
Mouse IgG2a Isotype Control (PE) |
abx200574-50ug |
Abbexa |
50 ug |
EUR 425 |
|
Mouse IgG2a Isotype Control (APC) |
abx200575-50ug |
Abbexa |
50 ug |
EUR 425 |
|
Mouse IgG2a Isotype Control (PerCP) |
abx200576-100ug |
Abbexa |
100 ug |
EUR 425 |
|
Mouse IgG2b Isotype Control (FITC) |
abx200581-100ug |
Abbexa |
100 ug |
EUR 314 |
|
Mouse IgG2b Isotype Control (PE) |
abx200582-50ug |
Abbexa |
50 ug |
EUR 425 |
|
the similar is true for 19.0% (n = 6266) of variants of unknown medical significance or conflicting interpretation reported in the ClinVar database. The outcomes of the structural evaluation can be found in the devoted net catalogue Missense3D-DB. For every of the four M variants, the outcomes of the structural evaluation are introduced in a pleasant concise format that may be included in medical genetic stories. An in depth report of the structural evaluation can also be accessible for the non-experts in structural biology. Population frequency and predictions from SIFT and PolyPhen are included for a extra complete variant interpretation. This is the first large-scale atom-based structural interpretation of human genetic variation and presents geneticists and the biomedical neighborhood a new method to genetic variant interpretation.