Small RNAs (sRNAs) are important regulatory molecules, and there are three main sRNA lessons in plants: microRNAs (miRNAs), phased small interfering RNAs (phased siRNAs or phasiRNAs), and heterochromatic siRNAs (hc-siRNAs). Excluding miRNAs, the opposite two lessons should not properly annotated or out there in public databases for many sequenced plant genomes. We carried out a complete sRNA annotation of 143 plant species which have absolutely sequenced genomes and next-generation sequencing sRNA knowledge publicly out there.
The outcomes can be found by way of an internet repository known as sRNAanno ( www.plantsRNAs.org ). Compared with different public plant sRNA databases, we obtained was rather more miRNA annotations, that are extra full and dependable as a result of of the constant and extremely stringent standards used in our miRNA annotations. sRNAanno additionally supplies free entry to genomic data for >22,721 PHAS loci and >22 million hc-siRNA loci annotated from these 143 plant species. Both miRNA and PHAS loci may be simply browsed to view their foremost options, and a group of archetypal trans-acting siRNA 3 (TAS3) genes had been annotated individually for fast entry.
To facilitate the benefit of sRNA annotation, sRNAanno supplies free service for sRNA annotations to the group. In abstract, the sRNAanno database is a superb useful resource to facilitate genomic and genetic analysis on plant small RNAs.Decompression illness (DCS) stays a significant operational concern for diving operations, submarine escape and high-altitude jumps. Aside from DCS signs, venous fuel emboli (VGE) detected with ultrasound post-dive are sometimes used as a marker of decompression stress in people, with a specificity of 100% regardless that the sensitivity is poor [1]. Being non-invasive, moveable and non-ionizing, ultrasound is especially suited to common and repeated monitoring. It might assist elucidate inter- and intra-subject variability in VGE and DCS susceptibility, however analyzing these recordings stays a cumbersome process [2].
Testing repository security evaluation fashions for deep geological disposal utilizing legacy contaminated websites
An necessary property of areas chosen to host deep geological repositories for increased stage radioactive wastes is their capability to retard the motion of any radionuclides launched from engineered limitations. Site characterization can’t measure this attribute immediately and therefore fashions kind the important hyperlink between subject observations and supporting laboratory rock/water/radionuclide interplay research. However, residual uncertainties all the time stay, related to the complexity of radionuclide interactions in pure environments and the extrapolations in time and area which can be included in security assessments. An under-used useful resource that might assist to strengthen the security instances that make the most of such data, is the data base out there from anthropogenically contaminated websites.
These have the potential to mix related geological settings with the radionuclides of curiosity and timescales in the order of many years enable usually gradual processes to be higher quantified. This paper supplies an summary of the vary of choices out there, critically critiques some related examples the place radionuclide migration fashions might be examined and descriptions work that might facilitate utilization of this potential useful resource in order to strengthen the security case for geological repositories.
Repository corticotropin injection (RCI), a posh combination of adrenocorticotropic hormone (ACTH) analogs and different pituitary peptides, has been discovered to suppress key points of gene expression and mobile operate in human B lymphocytes in vitro. The current research reveal that neither particular person POMC peptides nor different associated pituitary neuropeptides are ample to elicit these results, regardless that particular receptors succesful of transmitting indicators from these peptides are expressed by human B cells. RCI’s direct results on human B cells could require complementary indicators from a number of elements of the preparation.
Medicine Shortages: From Assumption to Evidence to Action – A Proposal for Using the FMD Data Repositories for Shortages Monitoring
Medicine shortages could negatively affect affected person care and the affected person expertise. Shortages needs to be a precedence of trade, provide chain stakeholders and nationwide competent authorities, and deserve greater than empathy or “lip-service” however critical engagement and motion. Under the overarching precept that with out right measurements in place there can’t be any enchancment in general efficiency (1), stakeholders in the pharmaceutical provide chain, notably pharmaceutical producers have made the decision for all related sources of data for use in order to offer further intelligence concerning the root causes and drivers of shortages, together with the identification of bottlenecks in the availability chain.
This paper outlines a proposal for utilizing the info saved in the interoperable community of nationwide repositories being arrange in the context of the Falsified Medicines Directive (Directive 2011/62/EU) and its Delegated Regulation 2016/161/EU on security options for offering further intelligence in monitoring shortages. The paper analyses the potential feasibility and readiness of utilizing this knowledge for monitoring shortages in addition to the strengths and weaknesses of the strategy. We discover additionally what are some of the opposite complementary knowledge sources that might be analyzed in conjunction with the info in the repository system to sharpen the general evaluation.
Anti-CD40 [A54 scFv] |
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MBS488460-02mg | MyBiosource | 0.2mg | EUR 520 |
Anti-CD40 [A54 scFv] |
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MBS488460-5x02mg | MyBiosource | 5x0.2mg | EUR 2160 |
2019-nCoV scFv antibody |
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PAab11133-1 | Nova Lifetech | 100ug | EUR 3500 |
Recombinant Anti p53 scFv |
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MBS140082-0002mg | MyBiosource | 0.002mg | EUR 240 |
Recombinant Anti p53 scFv |
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MBS140082-001mg | MyBiosource | 0.01mg | EUR 310 |
Recombinant Anti p53 scFv |
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MBS140082-1mg | MyBiosource | 1mg | EUR 5575 |
Recombinant Anti p53 scFv |
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MBS140082-5x1mg | MyBiosource | 5x1mg | EUR 24755 |
Tetanus Toxoid scFv Antibody |
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abx137499-100tests | Abbexa | 100 tests | EUR 225 |
Anti-Cardiac Troponin I [scFv 180] |
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MBS488422-02mg | MyBiosource | 0.2mg | EUR 520 |
Anti-Cardiac Troponin I [scFv 180] |
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MBS488422-5x02mg | MyBiosource | 5x0.2mg | EUR 2160 |
Anti-Cardiac Troponin I [scFv 180] |
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MBS488423-02mg | MyBiosource | 0.2mg | EUR 520 |
Anti-Cardiac Troponin I [scFv 180] |
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MBS488423-5x02mg | MyBiosource | 5x0.2mg | EUR 2160 |
Recombinant Anti-Tetanus Toxoid scFv |
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MBS140085-0002mg | MyBiosource | 0.002mg | EUR 240 |
Recombinant Anti-Tetanus Toxoid scFv |
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MBS140085-001mg | MyBiosource | 0.01mg | EUR 310 |
Recombinant Anti-Tetanus Toxoid scFv |
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MBS140085-1mg | MyBiosource | 1mg | EUR 5575 |
Recombinant Anti-Tetanus Toxoid scFv |
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MBS140085-5x1mg | MyBiosource | 5x1mg | EUR 24755 |
FMC63 scFv, His Tag (SPR verified) |
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CD9-M52Hb | ACROBIOSYSTEMS | 100ug | EUR 1487.3 |
Description: FMC63 scFv, His Tag (CD9-M52Hb) is expressed from human 293 cells (HEK293). It mimics the scFv presented on CAR-T cells which target CD19. |
2019-nCoV scFv antibody (S protein) |
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PAab11133 | Nova Lifetech | 100ug | EUR 450 |
Recombinant (E.Coli) Anti-p53 scFv IgG |
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RP-341 | Alpha Diagnostics | 10 ug | EUR 343.2 |
Recombinant anti-2019-nCoV NP ScFv |
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MBS8574824-005mg | MyBiosource | 0.05mg | EUR 705 |
Recombinant anti-2019-nCoV NP ScFv |
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MBS8574824-5x005mg | MyBiosource | 5x0.05mg | EUR 2910 |
pHrdSV40- scFv- GCN4- sfGFP- VP64- GB1- NLS |
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PVT10950 | Nova Lifetech | 2ug | EUR 215 |
Anti-TNFRSF8 (clone Ki4) scFv-MAP ADC |
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ADC-W-354 | Creative Biolabs | 1mg | Ask for price |
Description: This ADC product is comprised of an anti-TNFRSF8 monoclonal antibody (clone Ki4) conjugated via a linker to a MAP |
Rat neurofascin (Nfasc)-control Control/blocking peptide |
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AB-23249-CP | Alpha Diagnostics | 100ug | EUR 196.8 |
AS Control |
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A26 | DataApex | - | EUR 330 |
Description: SW module for AS control |
GC Control |
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A23 | DataApex | - | EUR 600 |
Description: SW module for GC control |
LC Control |
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A24 | DataApex | - | EUR 600 |
Description: SW module for HPLC/CE control (pump, det, etc.) |
Rat Control |
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DEV99RC | Demeditec Diagnostics | 2 x 1 ml | EUR 60 |
MDP control |
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tlrl-mdpcl | InvivoGen FR | 5 mg | EUR 148.05 |
BMP4 Control |
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MBS542571-5Applications | MyBiosource | 5Applications | EUR 335 |
BMP4 Control |
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MBS542571-5x5Applications | MyBiosource | 5x5Applications | EUR 1350 |
Rat IgG-PE conjugate (isotype control) (Isotype control) |
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20005-PE | Alpha Diagnostics | 25 tests | EUR 242.4 |
Rat IgG-HRP conjugate (isotype control) (Isotype control) |
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20005-HP | Alpha Diagnostics | 100 ug | EUR 196.8 |
Recombinant (E.Coli) Anti-Tetanus Toxoid scFv IgG |
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RP-343 | Alpha Diagnostics | 10 ug | EUR 343.2 |
NPY1R Control |
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MBS543000-5Applications | MyBiosource | 5Applications | EUR 335 |
ADCY3 Control |
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MBS543023-5Applications | MyBiosource | 5Applications | EUR 335 |
ADCY3 Control |
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MBS543023-5x5Applications | MyBiosource | 5x5Applications | EUR 1350 |
NPY1R Control |
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MBS543000-5x5Applications | MyBiosource | 5x5Applications | EUR 1350 |
pGIPZ control |
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PVTY00348 | Nova Lifetech | 2ug | EUR 280 |
pMD19- Control |
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PVT10564 | Nova Lifetech | 2ug | EUR 182 |
Rat IgG-FITC conjugate (isotype control) (Isotype control) |
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20005-F | Alpha Diagnostics | 100 ug | EUR 196.8 |
Control Slides |
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24012-1 | Polysciences Europe GmbH | 1box | EUR 78 |
Canine Control |
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DEV99CC | Demeditec Diagnostics | 2 x 1 ml | EUR 60 |
Dengue Control |
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ant-543 | ProSpec Tany | 100µg | EUR 165 |
Description: Mouse Anti-Dengue Control for Lateral Flow Test |
Canine Control |
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MBS495203-1Set | MyBiosource | 1Set | EUR 305 |
Canine Control |
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MBS495203-5x1Set | MyBiosource | 5x1Set | EUR 1390 |
pTRIPZ control |
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PVTY00369 | Nova Lifetech | 2ug | EUR 280 |
Rat IgG-Biotin conjugate (isotype control) (Isotype control) |
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20005-B | Alpha Diagnostics | 100 ug | EUR 196.8 |
SARS-CoV-2 Nucleocapsid Protein scFv Antibody |
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abx229488-100g | Abbexa | 100 µg | EUR 1725 |
Anti-ROR1 (clone R11) scFv-Fc-Sec ADC |
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ADC-W-434 | Creative Biolabs | 1mg | Ask for price |
Description: This ADC product is comprised of an anti-ROR1 scFv-Fc (clone R11) conjugated via a engineered selenocysteine (Sec) residue linker to a drug |
Quality Control |
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abx098966-1vial | Abbexa | 1 vial | EUR 360 |
Ascites, Control |
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MBS652640-10mL | MyBiosource | 10mL | EUR 415 |
Ascites, Control |
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MBS652640-1mL | MyBiosource | 1mL | EUR 190 |
Ascites, Control |
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MBS652640-5x10mL | MyBiosource | 5x10mL | EUR 1710 |
Goat IgG (-ve control for flow cytometry) (isotype control) |
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20011-100 | Alpha Diagnostics | 100 test | EUR 123.6 |
Control for Tyrosinase, 4 cases (1.5mm)HumanskinSkinIHC control |
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TYROSIN081 | Pantomics | 1.5mm | EUR 50 |
Negative Control |
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MBS2568128-1mL | MyBiosource | 1mL | EUR 140 |
Negative Control |
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MBS2568129-1mL | MyBiosource | 1mL | EUR 135 |
Positive Control |
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MBS2568130-1mL | MyBiosource | 1mL | EUR 150 |
Positive Control |
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MBS2568131-1mL | MyBiosource | 1mL | EUR 150 |
PIPET CONTROLLER CONTROL BOARD |
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357484 | CORNING | 1/pk | EUR 104.4 |
Description: Falcon Liquid Handling Equipment; Falcon Pipet Controllers and Accessories |
Control siRNA Vector (pGB-control) |
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9500C-20 | Biovision | each | EUR 405.6 |
OOSA10387-100T - IgM NEGATIVE CONTROL Negative/Isotype Control |
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OOSA10387-100T | Aviva Systems Biology | 100Tests | EUR 309 |
Anti-COVID-19 Nucleocapsid Protein scFv Antibody |
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E38A9964 | EnoGene | 100ug/100ul | EUR 225 |
Description: Available in various conjugation types. |
Anti-COVID-19 Nucleocapsid Protein scFv Antibody |
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MBS8309653-01mL | MyBiosource | 0.1mL | EUR 285 |
Anti-COVID-19 Nucleocapsid Protein scFv Antibody |
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MBS8309653-1mL | MyBiosource | 1mL | EUR 1585 |
Anti-COVID-19 Nucleocapsid Protein scFv Antibody |
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MBS8309653-5x1mL | MyBiosource | 5x1mL | EUR 7045 |
OOSA10342-100UG - IgG1 NEGATIVE CONTROL Negative/Isotype Control |
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OOSA10342-100UG | Aviva Systems Biology | 0.1mg | EUR 219 |
OOSA10349-100T - IgG2a NEGATIVE CONTROL Negative/Isotype Control |
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OOSA10349-100T | Aviva Systems Biology | 100Tests | EUR 299 |
OOSA10380-100T - IgG2b NEGATIVE CONTROL Negative/Isotype Control |
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OOSA10380-100T | Aviva Systems Biology | 100Tests | EUR 309 |
OOSA10389-100T - IgG1 NEGATIVE CONTROL Negative/Isotype Control |
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OOSA10389-100T | Aviva Systems Biology | 100Tests | EUR 309 |
OOSA10397-100T - IgG2a NEGATIVE CONTROL Negative/Isotype Control |
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OOSA10397-100T | Aviva Systems Biology | 100Tests | EUR 309 |
CypExpress Control |
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MBS480553-10g | MyBiosource | 10g | EUR 1905 |
CypExpress Control |
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MBS480553-1g | MyBiosource | 1g | EUR 320 |
CypExpress Control |
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MBS480553-5x10g | MyBiosource | 5x10g | EUR 8355 |
CypExpress Control |
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MBS480553-5x1g | MyBiosource | 5x1g | EUR 1220 |
ODN 2088 control |
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tlrl-2088c-1 | InvivoGen FR | 1 mg | EUR 546 |
ODN 2395 control |
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tlrl-2395c-1 | InvivoGen FR | 1 mg | EUR 546 |
Control for Mammaglobin, 4 cases (1.5mm)HumanBreastBreastIHC control |
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MAMA-G081 | Pantomics | 1.5mm | EUR 50 |
SERION ELISA Avidity control Rubella Virus Avidity Control IgG |
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MBS191655-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Control FD BNP |
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K023M-6 | Audit MicroControls | 6 x 1 mL | EUR 292 |
Description: Bi-Level |
Control FD TDM |
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K068M-6 | Audit MicroControls | 6 x 5 mL | EUR 205 |
Description: Tri-Level |
Control for GCDFP-15, 4 cases (1.5mm)HumanBreastBreastIHC control |
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GCDFP081 | Pantomics | 1.5mm | EUR 50 |
EDG-1 Control |
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BC-009 | Kamiya Biomedical Company | 100 uL | EUR 350 |
EDG-2 Control |
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BC-011 | Kamiya Biomedical Company | 100 uL | EUR 350 |
EDG-4 Control |
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BC-012 | Kamiya Biomedical Company | 100 uL | EUR 350 |
EDG-6 Control |
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BC-014 | Kamiya Biomedical Company | 100 uL | EUR 350 |
EDG-7 Control |
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BC-016 | Kamiya Biomedical Company | 100 uL | EUR 350 |
Rat Control IgG |
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AC034 | Abclonal | 100 ul | EUR 159.6 |
β-Gal Control |
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LV007 | ABM | 4 x 500 ul | EUR 195 |
NF-κB Control |
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T37559-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: NF-κB Control |
NF-κB Control |
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T37559-1g | TargetMol Chemicals | 1g | Ask for price |
Description: NF-κB Control |
NF-κB Control |
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T37559-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: NF-κB Control |
NF-κB Control |
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T37559-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: NF-κB Control |
NF-κB Control |
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T37559-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: NF-κB Control |
Rat Control IgG |
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MBS9144358-01mL | MyBiosource | 0.1mL | EUR 140 |
Rat Control IgG |
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MBS9144358-5x01mL | MyBiosource | 5x0.1mL | EUR 465 |
OOSA10361-1ML - Rat IgG2a NEGATIVE CONTROL Negative/Isotype Control |
|||
OOSA10361-1ML | Aviva Systems Biology | 1ml | EUR 169 |
SERION ELISA Avidity control Toxoplasma gondii Avidity Control IgG |
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MBS191654-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Control for MSH2, 4 cases (1.5mm)HumanDigestive systemColonIHC control |
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MSH2081 | Pantomics | 1.5mm | EUR 50 |
Control for Olig2, 4 cases (1.5mm)HumanNervous systemBrainIHC control |
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OLIG2081 | Pantomics | 1.5mm | EUR 50 |
Goat IgG control |
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31R-AG001 | Fitzgerald | 1 mg | EUR 104 |
Description: Goat Immunoglobulins Goat IgG control |
2'3'-cGAMP Control |
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tlrl-nagpap | InvivoGen FR | 1 mg | EUR 235.2 |
G3-YSD Control |
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tlrl-ydnac | InvivoGen FR | 200 µg | EUR 148.05 |
Rat IgG1 Control |
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mabg1-ctlrt | InvivoGen FR | 100 µg | Ask for price |
Goat IgG Control |
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GT15900 | Neuromics | 1 mg | EUR 199.2 |
MG-BSA Control |
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STA-306 | Cell Biolabs | 100 µg | EUR 386.4 |
Description:
|
Goat IgG control |
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MBS536227-1mg | MyBiosource | 1mg | EUR 255 |
Goat IgG control |
|||
MBS536227-5x1mg | MyBiosource | 5x1mg | EUR 1000 |
OOSA10379-250UG - Rat IgG2c NEGATIVE CONTROL Negative/Isotype Control |
|||
OOSA10379-250UG | Aviva Systems Biology | 0.25mg | EUR 319 |
Mouse IgG Control |
|||
10R-I169A | Fitzgerald | 250 ug | EUR 104 |
Description: Mouse Immunoglobulins Mouse IgG Control |
human IgM control |
|||
E4A11C04 | EnoGene | 50ug | EUR 255 |
Description: Available in various conjugation types. |
human IgE control |
|||
E4A11C05 | EnoGene | 50ug | EUR 255 |
Description: Available in various conjugation types. |
Mouse Control IgG |
|||
AC011 | Abclonal | 100 ul | EUR 143 |
Description: None |
ISD Control Naked |
|||
tlrl-isdcn | InvivoGen FR | 200 µg | EUR 148.05 |
Rat IgG2a Control |
|||
mabg2a-ctlrt | InvivoGen FR | 100 µg | EUR 101.85 |
Rat IgG2a Control |
|||
mabg2a-ctlrt-05 | InvivoGen FR | 5 x 100 µg | EUR 163.8 |
Rat IgG2b Control |
|||
mabg2b-ctlrt | InvivoGen FR | 100 µg | Ask for price |
Mouse IgM Control |
|||
ICIGMF-100 | ImmunoStep | 100 µg | EUR 239.4 |
Mouse IgM Control |
|||
ICIGMPU-100 | ImmunoStep | 100 µg | EUR 239.4 |
CEL-BSA Control |
|||
STA-302 | Cell Biolabs | 100 µg | EUR 245 |
CML-BSA Control |
|||
STA-314 | Cell Biolabs | 100 µg | EUR 386.4 |
Description:
|
MDA-BSA Control |
|||
STA-333 | Cell Biolabs | 100 µg | EUR 245 |
HNE-BSA Control |
|||
STA-335 | Cell Biolabs | 100 µg | EUR 245 |
Lastly, we offer a theoretical however concrete use case for utilizing the abovementioned knowledge for higher informing choices to forestall and mitigate shortages. In doing so, we clarify the interlink between affected person wants at nation stage, demand from financial actors, intra-EU parallel commerce and manufacturer-imposed provide quotas and suggest a mechanism for collaboration between nationwide competent authorities and provide chain stakeholders for early detection and motion to forestall drugs shortages from occurring.