OGP: A Repository of Experimentally Characterized O-Glycoproteins to Facilitate Studies on O-Glycosylation
Numerous research on most cancers, biopharmaceuticals, and medical trials have necessitated complete and exact evaluation of protein O-glycosylation. However, the lack of up to date and handy databases deters the storage of and reference to rising O-glycoprotein data. To resolve this difficulty, an O-glycoprotein repository named OGP was established in this work. It was constructed with a assortment of O-glycoprotein data from completely different sources. OGP accommodates 9354 O-glycosylation websites and 11,633 site-specific O-glycans mapping to 2133 O-glycoproteins, and it’s the largest O-glycoprotein repository to date. Based on the recorded O-glycosylation websites, an O-glycosylation web site prediction instrument was developed.
The first model of OGP repository and the web site enable customers to acquire numerous O-glycoprotein-related info, equivalent to protein accession numbers, O-glycosylation websites, glycopeptide sequences, site-specific glycan constructions, experimental strategies, and potential O-glycosylation websites. To tackle the challenges posed by large-scale development, validation, and adoption of synthetic intelligence (AI) in pathology, now we have constituted a consortium of teachers, small enterprises, and pharmaceutical corporations and proposed the BIGPICTURE challenge to the Innovative Medicines Initiative.
Our imaginative and prescient is to change into the catalyst in the digital transformation of pathology by creating the first European, ethically compliant, and quality-controlled entire slide imaging platform, in which each large-scale data and AI algorithms will exist. Our mission is to develop this platform in a sustainable and inclusive means, by connecting the neighborhood of pathologists, researchers, AI builders, sufferers, and trade events primarily based on creating worth and reciprocity in use primarily based on a neighborhood mannequin as the mechanism for making certain sustainability of the platform.
Missense3D-DB net catalogue: an atom-based evaluation and repository of 4M human protein-coding genetic variants
The interpretation of human genetic variation is one of the biggest challenges of fashionable genetics. New approaches are urgently wanted to prioritize variants, particularly these which might be uncommon or lack a definitive medical interpretation. We examined 10,136,597 human missense genetic variants from GnomAD, ClinVar and UniProt. We had been capable of carry out large-scale atom-based mapping and phenotype interpretation of 3,960,015 of these variants onto 18,874 experimental and 84,818 in home predicted three-dimensional coordinates of the human proteome.
We show that 14% of amino acid substitutions from the GnomAD database that could possibly be structurally analysed are predicted to have an effect on protein construction (n = 568,548, of which 566,439 uncommon or extraordinarily uncommon) and will, subsequently, have a but unknown disease-causing impact. Moreover, an OGP-based web site is already accessible (http://www.oglyp.org/). The web site contains 4 specifically designed and user-friendly modules: statistical evaluation, database search, web site prediction, and data submission.
Mouse IgG3 Isotype Control (FITC) |
abx405036-100tests |
Abbexa |
100 tests |
EUR 510 |
|
Mouse IgG3 Isotype Control (PerCP) |
abx200591-100ug |
Abbexa |
100 ug |
EUR 878.4 |
|
Mouse IgG3 Isotype Control Purified |
11-459-C025 |
ExBio |
0.025 mg |
EUR 105.6 |
Mouse IgG3 Isotype Control Purified |
11-459-C100 |
ExBio |
0.1 mg |
EUR 163.2 |
PE mouse IgG3, κ Isotype Control |
E16FMCP005K-025U |
EnoGene |
25 μg |
EUR 411.67 |
Description: Available in various conjugation types. |
FITC mouse IgG3, κ Isotype Control |
E16FMCF005K-050U |
EnoGene |
50 μg |
EUR 325 |
Description: Available in various conjugation types. |
Mouse IgG3 Isotype Control (OC-515) |
abx200593-100ug |
Abbexa |
100 ug |
EUR 727.2 |
|
Mouse IgG3 Isotype Control (CF-Blue) |
abx200592-100ug |
Abbexa |
100 ug |
EUR 577.2 |
|
Biotin mouse IgG3, κ Isotype Control |
E16FMCB005K-050U |
EnoGene |
50 μg |
EUR 260 |
Description: Available in various conjugation types. |
Purified mouse IgG3, κ Isotype Control |
E16FMCK005K-050U |
EnoGene |
50 μg |
EUR 411.67 |
Description: Available in various conjugation types. |
Mouse IgG3-PE conjugate (isotype control) |
20102-104-PE |
Alpha Diagnostics |
50 Tests |
EUR 242.4 |
Mouse IgG3-HRP conjugate (isotype control) |
20102-104-HP |
Alpha Diagnostics |
50 Tests |
EUR 196.8 |
Mouse IgG3-FITC conjugate (isotype control) |
20102-104-F |
Alpha Diagnostics |
50 tests |
EUR 196.8 |
NE Purified mouse IgG3, κ Isotype Control |
E16FMCY005K-500U |
EnoGene |
500 μg |
EUR 780 |
Description: Available in various conjugation types. |
Mouse IgG3-Biotin conjugate (isotype control) |
20102-104-B |
Alpha Diagnostics |
50 Tests |
EUR 196.8 |
Mouse IgG3 Isotype control (purified) validated fo |
NG908 |
Innovex |
7 ml |
EUR 245 |
Description: Mouse IgG3 Isotype control (purified) validated for IHC; Ready-To-Use |
Mouse IgG3 Isotype control (purified) validated fo |
NG908C |
Innovex |
1 ml |
EUR 285 |
Description: Mouse IgG3 Isotype control (purified) validated for IHC; Concentrate |
Mouse IgG3-PE-Cy5 conjugate (isotype control) |
20102-104-PC5 |
Alpha Diagnostics |
50 Tests |
EUR 270 |
Alexa Fluor® 488 mouse IgG3, κ Isotype Control |
E16FMCG005K-100U |
EnoGene |
100 μg |
EUR 845 |
Description: Available in various conjugation types. |
Alexa Fluor® 647 mouse IgG3, κ Isotype Control |
E16FMCK005K-025U |
EnoGene |
25 μg |
EUR 173.33 |
Description: Available in various conjugation types. |
Mouse IgG3 Isotype Control DyLight® 488 |
L4-459-C100 |
ExBio |
0.1 mg |
EUR 255.6 |
Mouse IgG3 Isotype Control DyLight® 650 |
L6-459-C100 |
ExBio |
0.1 mg |
EUR 255.6 |
Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PE |
IMSIGG3KICA1123CPE100UG |
Innovative research |
each |
EUR 150 |
|
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PE |
Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PE |
IMSIGG3KICA1123CPE25UG |
Innovative research |
each |
EUR 55 |
|
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PE |
Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 APC |
IMSIGG3KICA1123CAPC100UG |
Innovative research |
each |
EUR 150 |
|
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 APC |
Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 APC |
IMSIGG3KICA1123CAPC25UG |
Innovative research |
each |
EUR 55 |
|
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 APC |
Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 FITC |
IMSIGG3KICA1123CFITC100UG |
Innovative research |
each |
EUR 150 |
|
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 FITC |
Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 FITC |
IMSIGG3KICA1123CFITC25UG |
Innovative research |
each |
EUR 55 |
|
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 FITC |
Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 AF488 |
IMSIGG3KICA1123CAF488100UG |
Innovative research |
each |
EUR 150 |
|
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 AF488 |
Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 AF488 |
IMSIGG3KICA1123CAF48825UG |
Innovative research |
each |
EUR 55 |
|
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 AF488 |
Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 AF647 |
IMSIGG3KICA1123CAF647100UG |
Innovative research |
each |
EUR 150 |
|
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 AF647 |
Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 AF647 |
IMSIGG3KICA1123CAF64725UG |
Innovative research |
each |
EUR 55 |
|
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 AF647 |
Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 ER780 |
IMSIGG3KICA1123CER780100UG |
Innovative research |
each |
EUR 150 |
|
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 ER780 |
Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 ER780 |
IMSIGG3KICA1123CER78025UG |
Innovative research |
each |
EUR 55 |
|
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 ER780 |
Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 EV450 |
IMSIGG3KICA1123CEV450100UG |
Innovative research |
each |
EUR 150 |
|
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 EV450 |
Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 EV450 |
IMSIGG3KICA1123CEV45025UG |
Innovative research |
each |
EUR 55 |
|
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 EV450 |
Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 Biotin |
IMSIGG3KICA1123CBL100UG |
Innovative research |
each |
EUR 150 |
|
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 Biotin |
Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 Biotin |
IMSIGG3KICA1123CBL25UG |
Innovative research |
each |
EUR 55 |
|
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 Biotin |
Mouse IgG1 Isotype Control |
abx139001-01mg |
Abbexa |
0.1 mg |
EUR 376.8 |
|
Mouse IgG1 Isotype Control |
abx139002-01mg |
Abbexa |
0.1 mg |
EUR 376.8 |
|
Mouse IgG1 Isotype Control |
abx139008-01mg |
Abbexa |
0.1 mg |
EUR 376.8 |
|
Mouse IgG1 Isotype Control |
abx200564-100ug |
Abbexa |
100 ug |
EUR 376.8 |
|
Mouse IgG1 Isotype Control |
abx405007-01mg |
Abbexa |
0.1 mg |
EUR 493.2 |
|
Mouse IgG1 Isotype Control |
abx405009-05mg |
Abbexa |
0.5 mg |
EUR 828 |
|
Mouse IgG1 Isotype Control |
abx405012-1mg |
Abbexa |
1 mg |
EUR 1296 |
|
Mouse IgG1 Isotype Control |
abx405064-100tests |
Abbexa |
100 tests |
EUR 493.2 |
|
Mouse IgG1 Isotype Control |
abx405067-05mg |
Abbexa |
0.5 mg |
EUR 994.8 |
|
Mouse IgG1 Isotype Control |
E2790003 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
Mouse IgG1 Isotype Control |
ICIGG1PU-01MG |
ImmunoStep |
100 tests |
EUR 126.5 |
Mouse IgG2a Isotype Control |
abx139004-01mg |
Abbexa |
0.1 mg |
EUR 376.8 |
|
Mouse IgG2a Isotype Control |
abx139005-01mg |
Abbexa |
0.1 mg |
EUR 376.8 |
|
Mouse IgG2b Isotype Control |
abx139006-01mg |
Abbexa |
0.1 mg |
EUR 376.8 |
|
Mouse IgG2a Isotype Control |
abx139009-01mg |
Abbexa |
0.1 mg |
EUR 376.8 |
|
Mouse IgG2b Isotype Control |
abx139011-01mg |
Abbexa |
0.1 mg |
EUR 376.8 |
|
Mouse IgG2a Isotype Control |
abx200572-100ug |
Abbexa |
100 ug |
EUR 376.8 |
|
Mouse IgG2b Isotype Control |
abx200580-100ug |
Abbexa |
100 ug |
EUR 376.8 |
|
Mouse IgG2a Isotype Control |
abx405013-100tests |
Abbexa |
100 tests |
EUR 493.2 |
|
Mouse IgG2a Isotype Control |
abx405015-05mg |
Abbexa |
0.5 mg |
EUR 828 |
|
Mouse IgG2a Isotype Control |
abx405018-1mg |
Abbexa |
1 mg |
EUR 1328.4 |
|
Mouse IgG2b Isotype Control |
abx405056-100tests |
Abbexa |
100 tests |
EUR 493.2 |
|
Mouse IgG2b Isotype Control |
abx405061-1mg |
Abbexa |
1 mg |
EUR 1296 |
|
Mouse IgG2a Isotype Control |
abx405070-100tests |
Abbexa |
100 tests |
EUR 493.2 |
|
Mouse IgG2a Isotype Control |
abx405073-05mg |
Abbexa |
0.5 mg |
EUR 994.8 |
|
Mouse IgG2a Isotype Control |
10R-I117d |
Fitzgerald |
1 mg |
EUR 663.6 |
Description: Purified Mouse IgG2a Isotype Control |
Mouse IgG2a Isotype Control |
E2790004 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
Mouse IgG2b Isotype Control |
E2790005 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
Mouse IgG Isotype Control |
IC002-100ul |
SAB |
100ul |
EUR 146.4 |
Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PE/Cyanine5 |
IMSIGG3KICA1123CPECY5100UG |
Innovative research |
each |
EUR 150 |
|
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PE/Cyanine5 |
Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PE/Cyanine5 |
IMSIGG3KICA1123CPECY525UG |
Innovative research |
each |
EUR 55 |
|
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PE/Cyanine5 |
Mouse IgG1 Isotype Control (PE) |
abx139025-01mg |
Abbexa |
0.1 mg |
EUR 510 |
|
Mouse IgG1 Isotype Control (PE) |
abx200566-50ug |
Abbexa |
50 ug |
EUR 510 |
|
Mouse IgG1 Isotype Control PE |
1P-632-C025 |
ExBio |
0.025 mg |
EUR 146.4 |
Mouse IgG1 Isotype Control PE |
1P-632-C100 |
ExBio |
0.1 mg |
EUR 244.8 |
Mouse IgG1 Isotype Control (PE) |
E2790238 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
PE mouse IgG1 Isotype Control |
E16FMCP001-050 |
EnoGene |
50 tests |
EUR 235.2 |
Description: Available in various conjugation types. |
PE mouse IgG1 Isotype Control |
E16FMCP001-100 |
EnoGene |
100 Tests |
EUR 336 |
Description: Available in various conjugation types. |
Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PerCP/Cyanine5.5 |
IMSIGG3KICA1123CPERCPCY55100UG |
Innovative research |
each |
EUR 150 |
|
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PerCP/Cyanine5.5 |
Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PerCP/Cyanine5.5 |
IMSIGG3KICA1123CPERCPCY5525UG |
Innovative research |
each |
EUR 55 |
|
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PerCP/Cyanine5.5 |
Mouse IgG1 Isotype Control (APC) |
abx139022-01mg |
Abbexa |
0.1 mg |
EUR 510 |
|
Mouse IgG1 Isotype Control (APC) |
abx200567-50ug |
Abbexa |
50 ug |
EUR 510 |
|
Mouse IgG1 Isotype Control (RPE) |
abx405011-100tests |
Abbexa |
100 tests |
EUR 760.8 |
|
Mouse IgG1 Isotype Control (APC) |
abx405065-100tests |
Abbexa |
100 tests |
EUR 493.2 |
|
Mouse IgG1 Isotype Control (RPE) |
abx405069-100tests |
Abbexa |
100 tests |
EUR 560.4 |
|
Mouse IgG1 Isotype Control APC |
1A-632-C025 |
ExBio |
0.025 mg |
EUR 146.4 |
Mouse IgG1 Isotype Control APC |
1A-632-C100 |
ExBio |
0.1 mg |
EUR 244.8 |
Mouse IgG1 Isotype Control (APC) |
E2790221 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
APC mouse IgG1 Isotype Control |
E16FMCA001-050 |
EnoGene |
50 tests |
EUR 268.67 |
Description: Available in various conjugation types. |
APC mouse IgG1 Isotype Control |
E16FMCA001-100 |
EnoGene |
100 Tests |
EUR 403.2 |
Description: Available in various conjugation types. |
Mouse IgG1 Isotype Control (FITC) |
abx139024-01mg |
Abbexa |
0.1 mg |
EUR 460.8 |
|
Mouse IgG1 Isotype Control (FITC) |
abx200565-100ug |
Abbexa |
100 ug |
EUR 376.8 |
|
Mouse IgG1 Isotype Control (FITC) |
abx405010-01mg |
Abbexa |
0.1 mg |
EUR 610.8 |
|
Mouse IgG1 Isotype Control (FITC) |
abx405068-100tests |
Abbexa |
100 tests |
EUR 493.2 |
|
Mouse IgG1 Isotype Control FITC |
1F-632-C025 |
ExBio |
0.025 mg |
EUR 129.6 |
Mouse IgG1 Isotype Control FITC |
1F-632-C100 |
ExBio |
0.1 mg |
EUR 212.4 |
Mouse IgG1 Isotype Control (FITC) |
E2790234 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
FITC mouse IgG1 Isotype Control |
E16FMCF001-050 |
EnoGene |
50 tests |
EUR 168 |
Description: Available in various conjugation types. |
FITC mouse IgG1 Isotype Control |
E16FMCF001-100 |
EnoGene |
100 Tests |
EUR 268.8 |
Description: Available in various conjugation types. |
Mouse IgG1 Isotype Control (PerCP) |
abx139026-01mg |
Abbexa |
0.1 mg |
EUR 560.4 |
|
Mouse IgG1 Isotype Control (PerCP) |
abx200568-100ug |
Abbexa |
100 ug |
EUR 510 |
|
Mouse IgG1 Isotype Control PerCP |
PC-632-C025 |
ExBio |
0.025 mg |
EUR 163.2 |
Mouse IgG1 Isotype Control PerCP |
PC-632-C100 |
ExBio |
0.1 mg |
EUR 277.2 |
Mouse IgG2a Isotype Control (PE) |
abx139015-01mg |
Abbexa |
0.1 mg |
EUR 510 |
|
Mouse IgG2b Isotype Control (PE) |
abx139020-01mg |
Abbexa |
0.1 mg |
EUR 510 |
|
Mouse IgG2a Isotype Control (PE) |
abx200574-50ug |
Abbexa |
50 ug |
EUR 510 |
|
Mouse IgG2b Isotype Control (PE) |
abx200582-50ug |
Abbexa |
50 ug |
EUR 510 |
|
Mouse IgG2b Isotype Control PE |
1P-692-C025 |
ExBio |
0.025 mg |
EUR 146.4 |
Mouse IgG2b Isotype Control PE |
1P-692-C100 |
ExBio |
0.1 mg |
EUR 244.8 |
Mouse IgG2a Isotype Control PE |
1P-724-C025 |
ExBio |
0.025 mg |
EUR 146.4 |
Mouse IgG2a Isotype Control PE |
1P-724-C100 |
ExBio |
0.1 mg |
EUR 244.8 |
Mouse IgG2a Isotype Control (PE) |
E2790239 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
Mouse IgG2b Isotype Control (PE) |
E2790240 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
PE mouse IgG2a Isotype Control |
E16FMCP002-050 |
EnoGene |
50 tests |
EUR 235.2 |
Description: Available in various conjugation types. |
PE mouse IgG2a Isotype Control |
E16FMCP002-100 |
EnoGene |
100 Tests |
EUR 336 |
Description: Available in various conjugation types. |
PE mouse IgG2b Isotype Control |
E16FMCP003-050 |
EnoGene |
50 tests |
EUR 235.2 |
Description: Available in various conjugation types. |
PE mouse IgG2b Isotype Control |
E16FMCP003-100 |
EnoGene |
100 Tests |
EUR 336 |
Description: Available in various conjugation types. |
Mouse IgG1 Isotype Control (Biotin) |
abx139023-01mg |
Abbexa |
0.1 mg |
EUR 460.8 |
|
Mouse IgG1 Isotype Control (Biotin) |
abx405008-01mg |
Abbexa |
0.1 mg |
EUR 610.8 |
|
Mouse IgG1 Isotype Control (Biotin) |
abx405066-100tests |
Abbexa |
100 tests |
EUR 493.2 |
|
Mouse IgG1 Isotype Control Biotin |
1B-632-C025 |
ExBio |
0.025 mg |
EUR 129.6 |
Mouse IgG1 Isotype Control Biotin |
1B-632-C100 |
ExBio |
0.1 mg |
EUR 212.4 |
Biotin mouse IgG1 Isotype Control |
E16FMCB001-050 |
EnoGene |
50 tests |
EUR 168 |
Description: Available in various conjugation types. |
Biotin mouse IgG1 Isotype Control |
E16FMCB001-100 |
EnoGene |
100 Tests |
EUR 268.8 |
Description: Available in various conjugation types. |
Biotin mouse IgG1 Isotype Control |
E16FMCB001-100U |
EnoGene |
100 μg |
EUR 268.8 |
Description: Available in various conjugation types. |
Biotin mouse IgG1 Isotype Control |
E16FMCB001-500U |
EnoGene |
500 μg |
EUR 739.2 |
Description: Available in various conjugation types. |
Mouse IgG2a Isotype Control (APC) |
abx139012-01mg |
Abbexa |
0.1 mg |
EUR 510 |
|
Mouse IgG2b Isotype Control (APC) |
abx139017-01mg |
Abbexa |
0.1 mg |
EUR 510 |
|
Mouse IgG2a Isotype Control (APC) |
abx200575-50ug |
Abbexa |
50 ug |
EUR 510 |
|
Mouse IgG2b Isotype Control (APC) |
abx200583-50ug |
Abbexa |
50 ug |
EUR 510 |
|
Mouse IgG2a Isotype Control (RPE) |
abx405017-100tests |
Abbexa |
100 tests |
EUR 760.8 |
|
Mouse IgG2b Isotype Control (APC) |
abx405057-100tests |
Abbexa |
100 tests |
EUR 577.2 |
|
the similar is true for 19.0% (n = 6266) of variants of unknown medical significance or conflicting interpretation reported in the ClinVar database. The outcomes of the structural evaluation can be found in the devoted net catalogue Missense3D-DB. For every of the four M variants, the outcomes of the structural evaluation are introduced in a pleasant concise format that may be included in medical genetic stories. An in depth report of the structural evaluation can also be accessible for the non-experts in structural biology. Population frequency and predictions from SIFT and PolyPhen are included for a extra complete variant interpretation. This is the first large-scale atom-based structural interpretation of human genetic variation and presents geneticists and the biomedical neighborhood a new method to genetic variant interpretation.