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Acthar® Gel (repository corticotropin injection) dose-response relationships in an animal model of epileptic spasms

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Acthar® Gel (repository corticotropin injection) dose-response relationships in an animal model of epileptic spasms

Studies have been undertaken to judge the effectiveness of Acthar® Gel (repository corticotropin injection [RCI]) in the tetrodotoxin (TTX) model of early-life-induced epileptic spasms. Repository corticotropin injection (RCI) is broadly used in the United States to deal with childish spasms. A serious element of RCI is N25 deamidated ACTH. Additionally, we hoped to supply some perception into the attainable function circulating corticosteroids play in spasm cessation by evaluating the RCI dose-response relationships for spasm suppression to RCI-induced corticosterone launch from the adrenal gland. Spasms have been induced by persistent TTX infusion into the neocortex starting on postnatal day 11.

Repository corticotropin injection (RCI) dosages have been between Eight and 32 IU/kg/day. Drug titration protocols have been used, and comparisons have been made to injections of a automobile gel. Video/EEG recordings (24/7) monitored the drug’s results repeatedly for as much as 2 months. Tetrodotoxin (TTX)-infused management rats have been monitored for a similar interval of time. In separate experiments, the identical dosages of RCI got to rats and 1 h later plasma was collected and assayed for corticosterone. The value of care included MS-related inpatient, outpatient, and remedy prices. Treatment response was outlined as no proof of extra relapse therapy or process claims inside 30 days after therapy.

A parallel examine in contrast the consequences of 1-day and 10-day RCI remedies on circulating corticosterone. Results confirmed that RCI was ineffective at dosages of 8, 12, and 16 IU/kg/day however eradicated spasms in 66% of animals handled with 24 or 32 IU/kg/day. Treating animals with 32 IU/kg/day alone produced the identical diploma of spasms suppression as noticed throughout the titration protocols. In rats that had hypsarrhythmia-like exercise, RCI eradicated this irregular interictal EEG sample in all rats that grew to become seizure-free. In phrases of plasma corticosterone, 1- and 10-day remedies with RCI produced comparable will increase in this hormone and the degrees elevated linearly with rising dosages of RCI.

This stood in sharp distinction to the sigmoid-like dose-response curve for decreases in spasm counts. Our outcomes additional validate the TTX model as related for the examine of childish spasms. The model ought to be helpful for investigating how RCI acts to get rid of seizures and hypsarrhythmia. Dose-response outcomes recommend that both very excessive concentrations of circulating corticosteroids are required to abolish spasms or RCI acts by a distinct mechanism. In the oblique remedy comparability of six eligible scientific trial research, the chances of attaining efficacy outcomes have been 5 to eight instances larger with RCI than with tetracosactide and 14 to 16 instances larger than CCMC.

A Systematic Literature Review and Indirect Treatment Comparison of Efficacy of Repository Corticotropin Injection versus Synthetic Adrenocorticotropic Hormone for Infantile Spasms

Infantile spasms is a uncommon illness characterised by distinct seizures and hypsarrhythmia. Adrenocorticotropic hormone (ACTH) is on the market as a pure product (repository corticotropin injection, [RCI]; Acthar® Gel) and as artificial analogs. RCI is a naturally-sourced advanced combination of purified ACTH analogs and different pituitary peptides accredited by the United States Food and Drug Administration as a monotherapy for the remedy of childish spasms. RCI is usually used in the United States. Outside the United States, artificial analogs of ACTH-synthetic ACTH1-24 (tetracosactide) and artificial ACTH1-39 (corticotropin carboxymethyl-cellulose [CCMC])-are used.

The efficacy of RCI could differ from that of artificial ACTH remedies primarily based on the construction of peptide; nonetheless, no head-to-head scientific trials have in contrast the efficacy of RCI and artificial ACTH remedies. A scientific overview and oblique remedy comparability of scientific trials was carried out to evaluate the comparative efficacy of RCI and artificial ACTH remedies in childish spasms.

A search was carried out in MEDLINE, EMBASE, and Cochrane databases by September 30, 2020. Relevant scientific trials on RCI or artificial ACTH remedy and reporting both cessation of spasms or decision of hypsarrhythmia, individually or as a mixed final result have been included. A Bayesian oblique remedy comparability utilizing a fixed-effects model was used for comparative efficacy. Of 473 citations screened, 21 research have been reviewed qualitatively. This translated to a threat discount of 10% to 14% and 40% to 50% with RCI versus tetracosactide and CCMC, respectively.

For each two to 5 sufferers handled, RCI improved efficacy outcomes in one extra affected person in comparison with artificial ACTH (adjusted quantity needed-to-treat).Based on the out there restricted proof, outcomes recommend RCI could also be extra efficacious for childish spasms than artificial ACTH remedies. Our findings present a blueprint to tell the design of future potential research for the remedy of childish spasms.

Acthar® Gel (repository corticotropin injection) dose-response relationships in an animal model of epileptic spasms

Quality evaluation of real-world knowledge repositories throughout the info life cycle: A literature overview

Data high quality (DQ) have to be constantly outlined in context. The attributes, metadata, and context of longitudinal real-world knowledge (RWD) haven’t been formalized for high quality enchancment throughout the info manufacturing and curation life cycle. We sought to finish a literature overview on DQ evaluation frameworks, indicators and instruments for analysis, public well being, service, and high quality enchancment throughout the info life cycle. The overview adopted PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) pointers.
Databases from well being, bodily and social sciences have been used: Cinahl, Embase, Scopus, ProQuest, Emcare, PsycINFO, Compendex, and Inspec. Embase was used as an alternative of PubMed (an interface to go looking MEDLINE) as a result of it consists of all MeSH (Medical Subject Headings) phrases used and journals in MEDLINE in addition to extra distinctive journals and convention abstracts. A mixed knowledge life cycle and high quality framework guided the search of revealed and grey literature for DQ frameworks, indicators, and instruments. At least 2 authors independently recognized articles for inclusion and extracted and categorized DQ ideas and constructs. All authors mentioned findings iteratively till consensus was reached.

AAV2-LacZ Control Virus
AAV-342 50 ?L
EUR 1221.6
Description: LacZ control virus of AAV serotype 2.

AAV1-Luc Control Virus
AAV-321 50 ?L
EUR 1221.6
Description: Luciferase control virus of AAV serotype 1.

AAV3-Luc Control Virus
AAV-323 50 ?L
EUR 1221.6
Description: Luciferase control virus of AAV serotype 3.

AAV4-Luc Control Virus
AAV-324 50 ?L
EUR 1221.6
Description: Luciferase control virus of AAV serotype 4.

AAV5-Luc Control Virus
AAV-325 50 ?L
EUR 1221.6
Description: Luciferase control virus of AAV serotype 5.

AAV6-Luc Control Virus
AAV-326 50 ?L
EUR 1221.6
Description: Luciferase control virus of AAV serotype 6.

AAV1 Null Control Virus
AAV-351 50 ?L
EUR 1221.6
Description: Null (empty) control virus of AAV serotype 1.

AAV3 Null Control Virus
AAV-353 50 ?L
EUR 1221.6
Description: Null (empty) control virus of AAV serotype 3.

AAV4 Null Control Virus
AAV-354 50 ?L
EUR 1221.6
Description: Null (empty) control virus of AAV serotype 4.

AAV5 Null Control Virus
AAV-355 50 ?L
EUR 1221.6
Description: Null (empty) control virus of AAV serotype 5.

AAV6 Null Control Virus
AAV-356 50 ?L
EUR 1221.6
Description: Null (empty) control virus of AAV serotype 6.

AAV1-GFP Control Virus
AAV-301 50 ?L
EUR 1221.6
Description: GFP control virus of AAV serotype 1.

AAV3-GFP Control Virus
AAV-303 50 ?L
EUR 1221.6
Description: GFP control virus of AAV serotype 3.

AAV4-GFP Control Virus
AAV-304 50 ?L
EUR 1221.6
Description: GFP control virus of AAV serotype 4.

AAV5-GFP Control Virus
AAV-305 50 ?L
EUR 1221.6
Description: GFP control virus of AAV serotype 5.

AAV6-GFP Control Virus
AAV-306 50 ?L
EUR 1221.6
Description: GFP control virus of AAV serotype 6.

AAV1-Cre Control Virus
AAV-311 50 ?L
EUR 1221.6
Description: Cre control virus of AAV serotype 1.

AAV3-Cre Control Virus
AAV-313 50 ?L
EUR 1221.6
Description: Cre control virus of AAV serotype 3.

AAV4-Cre Control Virus
AAV-314 50 ?L
EUR 1221.6
Description: Cre control virus of AAV serotype 4.

AAV5-Cre Control Virus
AAV-315 50 ?L
EUR 1221.6
Description: Cre control virus of AAV serotype 5.

AAV6-Cre Control Virus
AAV-316 50 ?L
EUR 1221.6
Description: Cre control virus of AAV serotype 6.

AAV1-LacZ Control Virus
AAV-341 50 ?L
EUR 1221.6
Description: LacZ control virus of AAV serotype 1.

AAV3-LacZ Control Virus
AAV-343 50 ?L
EUR 1221.6
Description: LacZ control virus of AAV serotype 3.

AAV4-LacZ Control Virus
AAV-344 50 ?L
EUR 1221.6
Description: LacZ control virus of AAV serotype 4.

AAV5-LacZ Control Virus
AAV-345 50 ?L
EUR 1221.6
Description: LacZ control virus of AAV serotype 5.

AAV6-LacZ Control Virus
AAV-346 50 ?L
EUR 1221.6
Description: LacZ control virus of AAV serotype 6.

Lenti-III-PGK-Luc Control Virus
LV088 4 x 500 ul
EUR 195

saCas9 Nuclease AAV Virus (AAV2)
K209 2 x 250 µl, 1 x 10^9 GC/ml, Titer: 1 x 10^9 GC/ml
EUR 375
Description: This AAV vector expresses the Cas9 orthologue from Staphylococcus Aureus (saCas9). saCas9 is ~1 kb shorter than spCas9, allowing it to be efficiently packaged in AAV Virus. Furthermore, the saCas9 enzyme recognizes a longer PAM sequence than spCas9, and thus has greater editing specificity.AAV has low immunogenicity and broad host range, making it an ideal choice for both in vivo and in vitro applications. Use this saCas9-expressing AAV virus with a target-specific saCas9-compatible sgRNA for highly specific and efficient genome editing.

Adeno-Associated Virus 2, VP1 (AAV2)
MBS633442-005mg 0.05mg
EUR 995

Adeno-Associated Virus 2, VP1 (AAV2)
MBS633442-5x005mg 5x0.05mg
EUR 4330

Adeno-Associated Virus 2, VP1, VP2 (AAV2)
MBS600010-005mg 0.05mg
EUR 960

Adeno-Associated Virus 2, VP1, VP2 (AAV2)
MBS600010-5x005mg 5x0.05mg
EUR 4180

Adeno-Associated Virus 2 Replicase (AAV2 Replicase)
MBS600022-01mg 0.1mg
EUR 975

Adeno-Associated Virus 2 Replicase (AAV2 Replicase)
MBS600022-5x01mg 5x0.1mg
EUR 4245

Adeno-Associated Virus 2 Replicase (AAV2 Replicase)
MBS602012-005mg 0.05mg
EUR 975

Adeno-Associated Virus 2 Replicase (AAV2 Replicase)
MBS602012-5x005mg 5x0.05mg
EUR 4245

Adeno-Associated Virus 2 Replicase (AAV2 Replicase)
MBS602367-005mg 0.05mg
EUR 1005

Adeno-Associated Virus 2 Replicase (AAV2 Replicase)
MBS602367-5x005mg 5x0.05mg
EUR 4375

Adeno-Associated Virus 2, VP1, VP2, VP3 (AAV2)
MBS604703-005mg 0.05mg
EUR 1145

Adeno-Associated Virus 2, VP1, VP2, VP3 (AAV2)
MBS604703-5x005mg 5x0.05mg
EUR 5000

Adeno-Associated Virus 2, VP1, VP2, VP3 (AAV2)
MBS613487-025mL 0.25mL
EUR 1000

Adeno-Associated Virus 2, VP1, VP2, VP3 (AAV2)
MBS613487-5x025mL 5x0.25mL
EUR 4345

Adeno-Associated Virus 2, VP1, VP2, VP3 (AAV2)
MBS602359-005mg 0.05mg
EUR 970

Adeno-Associated Virus 2, VP1, VP2, VP3 (AAV2)
MBS602359-5x005mg 5x0.05mg
EUR 4210

Human Adeno-Associated Virus 2 (AAV2) ELISA Kit
abx050302-100g 100 µg Ask for price

Human Adeno-Associated Virus 2 (AAV2) ELISA Kit
abx050302-200g 200 µg Ask for price

Human Adeno-Associated Virus 2 (AAV2) ELISA Kit
abx050302-50g 50 µg
EUR 493.75

scAAV1-GFP Control Virus
AAV-331 50 ?L
EUR 1221.6
Description: Self-complementary GFP control virus of AAV serotype 1.

scAAV2-GFP Control Virus
AAV-332 50 ?L
EUR 1221.6
Description: Self-complementary GFP control virus of AAV serotype 2.

scAAV3-GFP Control Virus
AAV-333 50 ?L
EUR 1221.6
Description: Self-complementary GFP control virus of AAV serotype 3.

scAAV4-GFP Control Virus
AAV-334 50 ?L
EUR 1221.6
Description: Self-complementary GFP control virus of AAV serotype 4.

scAAV5-GFP Control Virus
AAV-335 50 ?L
EUR 1221.6
Description: Self-complementary GFP control virus of AAV serotype 5.

scAAV6-GFP Control Virus
AAV-336 50 ?L
EUR 1221.6
Description: Self-complementary GFP control virus of AAV serotype 6.

KRV Virus Positive Control
MBS412091-1mL 1mL
EUR 175

KRV Virus Positive Control
MBS412091-5x1mL 5x1mL
EUR 645

Zika Virus Negative Control
MBS412678-05mL 0.5mL
EUR 100

Zika Virus Negative Control
MBS412678-5x05mL 5x0.5mL
EUR 305

Zika Virus Positive Control
MBS412728-05mL 0.5mL
EUR 195

Zika Virus Positive Control
MBS412728-5x05mL 5x0.5mL
EUR 730

Foamy Virus Negative Control
MBS412663-05mL 0.5mL
EUR 100

Foamy Virus Negative Control
MBS412663-5x05mL 5x0.5mL
EUR 305

Foamy Virus Positive Control
MBS412713-05mL 0.5mL
EUR 195

Foamy Virus Positive Control
MBS412713-5x05mL 5x0.5mL
EUR 730

HSV-1 Virus Control Stock
20-4810020 Single Use, 400 µL, shipped frozen Ask for price
Description: Genetically Engineered BHK Cells

HSV-2 Virus Control Stock
20-4820020 Single Use, 400 µL, shipped frozen Ask for price
Description: Genetically Engineered BHK Cells

Zika Virus NS1 Control Antigen
BA149R01 1 mg
EUR 947

Measles Virus IgG Control Serum
C102G 3 mL
EUR 105

Measles Virus IgM Control Serum
C102M 3 mL
EUR 105

Rubella Virus IgG Control Serum
C129G 3 mL
EUR 105

Rubella Virus IgM Control Serum
C129M 3 mL
EUR 105

Mouse K Virus Positive Control
MBS412089-1mL 1mL
EUR 195

Mouse K Virus Positive Control
MBS412089-5x1mL 5x1mL
EUR 720

Zika Virus NS5 Positive Control
MBS543408-5Applications 5Applications
EUR 335

Zika Virus NS5 Positive Control
MBS543408-5x5Applications 5x5Applications
EUR 1350

Zika Virus NS1 Positive Control
MBS5400765-5Applications 5Applications
EUR 335

Zika Virus NS1 Positive Control
MBS5400765-5x5Applications 5x5Applications
EUR 1350

Zika Virus NS2 Positive Control
MBS5400766-5Applications 5Applications
EUR 335

Zika Virus NS2 Positive Control
MBS5400766-5x5Applications 5x5Applications
EUR 1350

Zika Virus NS3 Positive Control
MBS5400767-5Applications 5Applications
EUR 335

Zika Virus NS3 Positive Control
MBS5400767-5x5Applications 5x5Applications
EUR 1350

Lenti-III-UBC-GFP Control Virus
LV027 4 x 500 ul
EUR 195

Lenti-III-PGK-GFP Control Virus
LV028 4 x 500 ul
EUR 195

Epstein-Barr Virus (EBV) Control
MBS568624-1mL 1mL
EUR 300

Epstein-Barr Virus (EBV) Control
MBS568624-25mL 25mL
EUR 2830

Epstein-Barr Virus (EBV) Control
MBS568624-5x25mL 5x25mL
EUR 12475

Rat Hanta Virus Positive Control
MBS412088-1mL 1mL
EUR 175

Rat Hanta Virus Positive Control
MBS412088-5x1mL 5x1mL
EUR 645

West Nile Virus Negative Control
MBS412656-05mL 0.5mL
EUR 100

West Nile Virus Negative Control
MBS412656-5x05mL 5x0.5mL
EUR 305

West Nile Virus Positive Control
MBS412706-05mL 0.5mL
EUR 195

West Nile Virus Positive Control
MBS412706-5x05mL 5x0.5mL
EUR 730

Mouse Zika Virus Positive Control
MBS412086-05mL 0.5mL
EUR 175

Mouse Zika Virus Positive Control
MBS412086-5x05mL 5x0.5mL
EUR 645

Rat Sendai Virus Positive Control
MBS412130-1mL 1mL
EUR 175

Rat Sendai Virus Positive Control
MBS412130-5x1mL 5x1mL
EUR 645

Mouse Hanta Virus Positive Control
MBS412087-1mL 1mL
EUR 175

Mouse Hanta Virus Positive Control
MBS412087-5x1mL 5x1mL
EUR 645

SERION ELISA Avidity control Rubella Virus Avidity Control IgG
MBS191655-INQUIRE INQUIRE Ask for price

pRedTK-CMV Virus [positive control]
SR10052VA-1 >2 x 10^6 IFUs
EUR 625

Mouse Sendai Virus Positive Control
MBS412108-1mL 1mL
EUR 175

Mouse Sendai Virus Positive Control
MBS412108-5x1mL 5x1mL
EUR 645

Lenti-III-EF1alpha-GFP Control Virus
LV046 4 x 500 ul
EUR 195

pRedZeo-CMV Virus [positive control]
SR10046VA-1 >2 x 10^6 IFUs
EUR 625

Mouse Polyoma Virus Positive Control
MBS412112-1mL 1mL
EUR 175

Mouse Polyoma Virus Positive Control
MBS412112-5x1mL 5x1mL
EUR 645

Rat Pneumonia Virus Positive Control
MBS412129-1mL 1mL
EUR 175

Rat Pneumonia Virus Positive Control
MBS412129-5x1mL 5x1mL
EUR 645

Rabbit Sendai Virus Positive Control
MBS412177-1mL 1mL
EUR 175

Rabbit Sendai Virus Positive Control
MBS412177-5x1mL 5x1mL
EUR 645

Hamster Sendai Virus Positive Control
MBS412174-1mL 1mL
EUR 175

Hamster Sendai Virus Positive Control
MBS412174-5x1mL 5x1mL
EUR 645

pGreenZeo-CMV Virus [positive control]
SR501VA-1 >2 x 10^6 IFUs
EUR 608

Mouse Pneumonia Virus Positive Control
MBS412106-1mL 1mL
EUR 175

Mouse Pneumonia Virus Positive Control
MBS412106-5x1mL 5x1mL
EUR 645

Zika Virus Human IgA Assay Control
BC149A 1 mL
EUR 105

Zika Virus Human IgG Assay Control
BC149G 1 mL
EUR 105

Zika Virus Human IgM Assay Control
BC149M 1 mL
EUR 105

pGreenZeo-mCMV Virus [negative control]
SR500VA-1 >2 x 10^6 IFUs
EUR 608

Mouse Ectromelia Virus Positive Control
MBS412109-1mL 1mL
EUR 175

Mouse Ectromelia Virus Positive Control
MBS412109-5x1mL 5x1mL
EUR 645

Rabbit Pneumonia Virus Positive Control
MBS412176-1mL 1mL
EUR 175

Rabbit Pneumonia Virus Positive Control
MBS412176-5x1mL 5x1mL
EUR 645

Rat Adeno Associated Virus type 2 Antibody (AAV2-Ab) ELISA kit
E02A0397-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat Adeno Associated Virus type 2 Antibody (AAV2-Ab) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Adeno Associated Virus type 2 Antibody (AAV2-Ab) ELISA kit
E02A0397-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat Adeno Associated Virus type 2 Antibody (AAV2-Ab) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Adeno Associated Virus type 2 Antibody (AAV2-Ab) ELISA kit
E02A0397-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat Adeno Associated Virus type 2 Antibody (AAV2-Ab) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Adeno Associated Virus type 2 Antibody (AAV2-Ab) Elisa kit
E01A8879 96T
EUR 700
Description: ELISA

Dog Adeno Associated Virus type 2 Antibody (AAV2-Ab) ELISA kit
E08A0397-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Canine Adeno Associated Virus type 2 Antibody (AAV2-Ab) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Adeno Associated Virus type 2 Antibody (AAV2-Ab) ELISA kit
E08A0397-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine Adeno Associated Virus type 2 Antibody (AAV2-Ab) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Adeno Associated Virus type 2 Antibody (AAV2-Ab) ELISA kit
E08A0397-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine Adeno Associated Virus type 2 Antibody (AAV2-Ab) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Adeno Associated Virus type 2 Antibody (AAV2-Ab) ELISA kit
E07A0397-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine Adeno Associated Virus type 2 Antibody (AAV2-Ab) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Adeno Associated Virus type 2 Antibody (AAV2-Ab) ELISA kit
E07A0397-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine Adeno Associated Virus type 2 Antibody (AAV2-Ab) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Adeno Associated Virus type 2 Antibody (AAV2-Ab) ELISA kit
E07A0397-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine Adeno Associated Virus type 2 Antibody (AAV2-Ab) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Hamster Pneumonia Virus Positive Control
MBS412171-1mL 1mL
EUR 175

Hamster Pneumonia Virus Positive Control
MBS412171-5x1mL 5x1mL
EUR 645

Goat Adeno Associated Virus type 2 Antibody (AAV2-Ab) Elisa kit
E01A43800 96T
EUR 700
Description: ELISA

Goat Adeno Associated Virus type 2 Antibody (AAV2-Ab) ELISA kit
E06A0397-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat Adeno Associated Virus type 2 Antibody (AAV2-Ab) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Adeno Associated Virus type 2 Antibody (AAV2-Ab) ELISA kit
E06A0397-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat Adeno Associated Virus type 2 Antibody (AAV2-Ab) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Adeno Associated Virus type 2 Antibody (AAV2-Ab) ELISA kit
E06A0397-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat Adeno Associated Virus type 2 Antibody (AAV2-Ab) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dengue Virus Human IgG Assay Control
BC114G 1 mL
EUR 105

Dengue Virus Human IgM Assay Control
BC114M 1 mL
EUR 105

Influenza A Virus IgA Control Serum
C1231A 3 mL
EUR 105

Influenza A Virus IgG Control Serum
C1231G 3 mL
EUR 105

Influenza A Virus IgM Control Serum
C1231M 3 mL
EUR 105

Influenza B Virus IgA Control Serum
C1232A 3 mL
EUR 105

Influenza B Virus IgG Control Serum
C1232G 3 mL
EUR 105
The 120 included articles yielded ideas associated to contextual (knowledge supply, custodian, and consumer) and technical (interoperability) elements throughout the info life cycle. Contextual DQ subcategories included relevance, usability, accessibility, timeliness, and belief. Well-tested computable DQ indicators and evaluation instruments have been additionally discovered.  A DQ evaluation framework that covers intrinsic, technical, and contextual classes throughout the info life cycle permits evaluation and administration of RWD repositories to make sure health

A content-based dataset recommendation system for researchers-a case study on Gene Expression Omnibus (GEO) repository

by
A content-based dataset recommendation system for researchers-a case study on Gene Expression Omnibus (GEO) repository

It is a rising development amongst researchers to make their knowledge publicly obtainable for experimental reproducibility and knowledge reusability. Sharing knowledge with fellow researchers helps in growing the visibility of the work. On the opposite hand, there are researchers who’re inhibited by the shortage of knowledge sources. To overcome this problem, many repositories and data bases have been established to this point to ease knowledge sharing. Further, prior to now 20 years, there was an exponential enhance within the variety of datasets added to those dataset repositories.

However, most of those repositories are domain-specific, and none of them can advocate datasets to researchers/customers. Naturally, it’s difficult for a researcher to maintain monitor of all of the related repositories for potential use. Thus, a dataset recommender system that recommends datasets to a researcher primarily based on earlier publications can improve their productiveness and expedite additional analysis. The potential to focus onto subnetworks, a number of visualizations and simulation choices will allow the AMD analysis neighborhood to computationally mannequin subnetworks or to check experimentally new hypotheses arising from connectivities in the AMD pathway map.

This work adopts an info retrieval (IR) paradigm for dataset recommendation. We hypothesize that two elementary variations exist between dataset recommendation and PubMed-style biomedical IR past the corpus. First, as an alternative of key phrases, the question is the researcher, embodied by his or her publications. Second, to filter the related datasets from non-relevant ones, researchers are higher represented by a set of pursuits, versus your entire physique of their analysis. This second strategy is applied utilizing a non-parametric clustering method.

These clusters are used to advocate datasets for every researcher utilizing the cosine similarity between the vector representations of publication clusters and datasets. The most normalized discounted cumulative acquire at 10 (NDCG@10), precision at 10 (p@10) partial and p@10 strict of 0.89, 0.78 and 0.61, respectively, have been obtained utilizing the proposed methodology after handbook analysis by 5 researchers. As per one of the best of our data, that is the primary study of its variety on content-based dataset recommendation.

Cancer PRSweb: An Online Repository with Polygenic Risk Scores for Major Cancer Traits and Their Evaluation in Two Independent Biobanks

To facilitate scientific collaboration on polygenic threat scores (PRSs) analysis, we created an intensive PRS on-line repository for 35 frequent most cancers traits integrating freely obtainable genome-wide affiliation research (GWASs) abstract statistics from three sources: printed GWASs, the NHGRI-EBI GWAS Catalog, and UK Biobank-based GWASs. Our framework condenses these abstract statistics into PRSs utilizing varied approaches comparable to linkage disequilibrium pruning/p worth thresholding (mounted or data-adaptively optimized thresholds) and penalized, genome-wide impact dimension weighting.
We evaluated the PRSs in two biobanks: the Michigan Genomics Initiative (MGI), a longitudinal biorepository effort at Michigan Medicine, and the population-based UK Biobank (UKB). For every PRS assemble, we offer measures on predictive efficiency and discrimination. Besides PRS analysis, the Cancer-PRSweb platform options assemble downloads and phenome-wide PRS affiliation study outcomes (PRS-PheWAS) for predictive PRSs. We count on this built-in platform to speed up PRS-related most cancers analysis.
This multicenter, double-blind, randomized, placebo-controlled study enrolled sufferers ≥ 18 years with lively SLE and reasonable to extreme rash and/or arthritis regardless of steady glucocorticoid doses (7.5-30 mg/day prednisone equal) and antimalarials for ≥ Four weeks and/or immunosuppressants for ≥ eight weeks earlier than screening. Stable glucocorticoid doses have been required by way of week 16 with optionally available taper from weeks 16 to 24.
Patients have been randomized (1:1) to 80 U RCI subcutaneously or placebo each different day to week 4, then twice weekly to week 24. Endpoints included the proportion of SLE Responder Index (SRI)-Four responders at week 16; modifications from baseline to week 16 in 28 Swollen Joint Count/Tender Joint Count (28 SJC/TJC) and Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI)-Activity rating; and modifications from baseline to week 24 in inflammatory cytokines. Safety was assessed by antagonistic occasions.
A content-based dataset recommendation system for researchers-a case study on Gene Expression Omnibus (GEO) repository

Advancing COVID-19 differentiation with a sturdy preprocessing and integration of multi-institutional open-repository laptop tomography datasets for deep studying evaluation

The coronavirus pandemic and its unprecedented penalties globally has spurred the curiosity of the synthetic intelligence analysis neighborhood. A plethora of printed research have investigated the position of imaging comparable to chest X-rays and laptop tomography in coronavirus illness 2019 (COVID-19) automated analysis. Οpen repositories of medical imaging knowledge can play a big position by selling cooperation amongst institutes in a world-wide scale. However, they might induce limitations associated to variable knowledge high quality and intrinsic variations because of the huge number of scanner distributors and imaging parameters.

In this study, a state-of-the-art customized U-Net mannequin is offered with a cube similarity coefficient efficiency of 99.6% together with a switch studying VGG-19 primarily based mannequin for COVID-19 versus pneumonia differentiation exhibiting an space underneath curve of 96.1%. The above was considerably improved over the baseline mannequin skilled with no segmentation in chosen tomographic slices of the identical dataset. The offered study highlights the significance of a sturdy preprocessing protocol for picture evaluation inside a heterogeneous imaging dataset and assesses the potential diagnostic worth of the offered COVID-19 mannequin by evaluating its efficiency to the state-of-the-art. Health-related knowledge is saved in various repositories which can be managed and managed by completely different entities.

Purified Chicken IgY Isotype Control
E16FCCU013-025 25 μl
EUR 541.67
Description: Available in various conjugation types.

Chicken IgY Isotype Control Antibody
MBS1564106-01mg 0.1mg
EUR 340

Chicken IgY Isotype Control Antibody
MBS1564106-5x01mg 5x0.1mg
EUR 1235

IgY, Chicken Isotype Control (HRP)
MBS655648-1mL 1mL
EUR 375

IgY, Chicken Isotype Control (HRP)
MBS655648-5x1mL 5x1mL
EUR 1530

Chicken IgG Fab fragment (isotype control, non-immune), purified
20010-Fab-1 0.5 mg
EUR 270

Chicken IgG-Fc unlabeled (isotype control, non-immune), purified
20010-3-UL 0.1 mg
EUR 242.4

Chicken IgG-HRP conjugate (isotype control, non-immune), purified
20010-1-HP 0.5 mg
EUR 270

Chicken IgG-FITC conjugate (isotype control, non-immune), purified
20010-1-F 0.5 mg
EUR 270

Chicken IgG-Biotin conjugate (isotype control, non-immune), purified
20010-1-B 0.5 mg
EUR 270

Chicken IgM-Biotin conjugate (isotype control, non-immune) purified
20010-2-1-b 0.1 mg
EUR 270

Chicken IgG-Fc-HRP conjugate (isotype control, non-immune), purified
20010-3-HP 0.1 mg
EUR 270

Chicken IgG-Fc-FITC conjugate (isotype control, non-immune), purified
20010-3-F 0.1 mg
EUR 270

Chicken IgG-Fc-Biotin conjugate (isotype control, non-immune), purified
20010-3-B 0.1 mg
EUR 270

Control Normal Chicken IgY
MBS153731-1mg 1mg
EUR 205

Control Normal Chicken IgY
MBS153731-5x1mg 5x1mg
EUR 900

Rat IgG-PE conjugate (isotype control) (Isotype control)
20005-PE 25 tests
EUR 242.4

Rat IgG-HRP conjugate (isotype control) (Isotype control)
20005-HP 100 ug
EUR 196.8

Rat IgG-FITC conjugate (isotype control) (Isotype control)
20005-F 100 ug
EUR 196.8

Rat IgG-Biotin conjugate (isotype control) (Isotype control)
20005-B 100 ug
EUR 196.8

Rabbit Isotype Control
abx200646-100ug 100 ug
EUR 393.6

Rabbit Isotype Control
IMN-001 100 µg
EUR 239.4

Rat IgG Isotype Control
31-AR15 10 mg
EUR 183
Description: Purified Rat IgG Isotype Control

Rat IgG Isotype Control
GWB-37FCE4 10 mg Ask for price

Rat IgG Isotype Control
GWB-4BFFB2 0.5 mg Ask for price

Rat IgM Isotype Control
GWB-58F247 0.1 mg Ask for price

Rat IgM Isotype Control
GWB-5EE54A 0.5 mg Ask for price

Rat IgM Isotype Control
GWB-649C16 0.5 mg Ask for price

Dog IgG Isotype Control
GWB-323C1E 5 mg Ask for price

Rat IgG Isotype Control
GWB-1E8B74 0.1 mg Ask for price

Rat IgM Isotype Control
GWB-A128B8 0.5 mg Ask for price

Rat IgM Isotype Control
GWB-A6187D 0.5 mg Ask for price

Rat IgM Isotype Control
GWB-AAC8DF 0.1 mg Ask for price

Rat IgM Isotype Control
GWB-73539C 0.5 mg Ask for price

Rat IgG Isotype Control
GWB-76BDF3 0.1 mg Ask for price

Rat IgG Isotype Control
GWB-787682 0.1 mg Ask for price

Rat IgG Isotype Control
GWB-7A6404 0.1 mg Ask for price

Rat IgG Isotype Control
GWB-F39C54 0.5 mg Ask for price

Rat IgG Isotype Control
GWB-F7A192 0.5 mg Ask for price

Rat IgG Isotype Control
GWB-B6F703 0.1 mg Ask for price

Rat IgM Isotype Control
GWB-BD20D2 0.1 mg Ask for price

Rat IgG Isotype Control
GWB-CFDA81 0.1 mg Ask for price

Rat IgM Isotype Control
GWB-D02CC7 0.1 mg Ask for price

Rat IgG Isotype Control
GWB-D9CFB7 0.1 mg Ask for price

Rat IgG Isotype Control
GWB-BEE47C 0.1 mg Ask for price

Rat IgM Isotype Control
RIGMA-100 100 µg
EUR 846.24

Rat IgM Isotype Control
RIGMB-200 200 µg
EUR 933.6

Rat IgM Isotype Control
RIGMB-50 50 µg
EUR 304.61

Rat IgM Isotype Control
RIGMF-200 200 µg
EUR 933.6

Rat IgM Isotype Control
RIGMF-50 50 µg
EUR 304.61

Rat IgM Isotype Control
RIGMPE-100 100 µg
EUR 549.22

Rat IgM Isotype Control
RIGMPE-25 25 µg
EUR 287.14

Rat IgM Isotype Control
RIGMPP5.5-25 25 µg
EUR 426.91

Rat IgM Isotype Control
RIGMPU-50 50 µg
EUR 217.25

Rat IgM Isotype Control
RIGMPU-500 500 µg
EUR 479.33

IgG, Rat Isotype Control
MBS655490-5mg 5mg
EUR 395

IgG, Rat Isotype Control
MBS655490-5x5mg 5x5mg
EUR 1630

IgM, Rat Isotype Control
MBS655629-05mg 0.5mg
EUR 450

IgM, Rat Isotype Control
MBS655629-5x05mg 5x0.5mg
EUR 1880

Rat IgG Isotype Control
MBS537341-10mg 10mg
EUR 380

Rat IgG Isotype Control
MBS537341-5x10mg 5x10mg
EUR 1550

Rat IgG1 Isotype Control
abx405020-05mg 0.5 mg
EUR 460.8

Rat IgG1 Isotype Control
abx405039-05mg 0.5 mg
EUR 460.8

Rat IgG1 Isotype Control
20-abx405041
  • Ask for price
  • Ask for price
  • 0.1 mg
  • 1 mg

Rat IgG1 Isotype Control
GWB-472B42 0.1 mg Ask for price

Rat IgG1 Isotype Control
GWB-473962 0.1 mg Ask for price

Rat IgG1 Isotype Control
GWB-62835E 0.1 mg Ask for price

Rat IgG1 Isotype Control
GWB-655784 0.5 mg Ask for price

Rat IgG1 Isotype Control
GWB-206FB5 0.1 mg Ask for price

Goat IgG Isotype Control
GWB-224618 10 mg Ask for price

Rat IgG1 Isotype Control
GWB-1672AF 0.1 mg Ask for price

Goat IgG Isotype Control
GWB-1D14C3 100 TESTS Ask for price

Rat IgG1 Isotype Control
GWB-1D80D3 0.5 mg Ask for price

Goat IgG Isotype Control
GWB-9C0B03 100 TESTS Ask for price

Rat IgG1 Isotype Control
GWB-7404ED 0.5 mg Ask for price

Goat IgG Isotype Control
GWB-7B95C3 0.5 mg Ask for price

Rat IgG1 Isotype Control
GWB-7E930C 0.1 mg Ask for price

Goat IgG Isotype Control
GWB-B5EB81 100 TESTS Ask for price

Rat IgG1 Isotype Control
GWB-B963FB 0.5 mg Ask for price

Rat IgG1 Isotype Control
GWB-DFED32 0.1 mg Ask for price

Goat IgG Isotype Control
GWB-E035B6 100 TESTS Ask for price

Goat IgG Isotype Control
GWB-D15A0C 100 TESTS Ask for price

Rat IgG1 Isotype Control
RIGG1A-100 100 µg
EUR 654.05

Rat IgG1 Isotype Control
RIGG1A-25 25 µg
EUR 322.08

Rat IgG1 Isotype Control
RIGG1F-50 50 µg
EUR 357.02

Rat IgG1 Isotype Control
RIGG1F-500 500 µg
EUR 1055.9

Rat IgG1 Isotype Control
RIGG1PE-100 100 µg
EUR 636.58

Rat IgG1 Isotype Control
RIGG1PE-25 25 µg
EUR 304.61

Rat IgG1 Isotype Control
RIGG1PP5.5-100 100 µg
EUR 706.46

Rat IgG1 Isotype Control
RIGG1PP5.5-25 25 µg
EUR 322.08

Rat IgG1 Isotype Control
RIGG1PU-50 50 µg
EUR 217.25

Rat IgG1 Isotype Control
RIGG1PU-500 500 µg
EUR 479.33

Rat IgG1 Isotype Control
abx405039-100g 100 µg
EUR 275

Rat IgG1 Isotype Control
abx405041-100g 100 µg
EUR 200

IgG1, Rat Isotype Control
MBS655540-05mg 0.5mg
EUR 420

IgG1, Rat Isotype Control
MBS655540-5x05mg 5x0.5mg
EUR 1730

IgG, Goat Isotype Control
MBS655594-5mg 5mg
EUR 370

IgG, Goat Isotype Control
MBS655594-5x5mg 5x5mg
EUR 1505

IgG, Goat Isotype Control
MBS655640-4mg 4mg
EUR 385

IgG, Goat Isotype Control
MBS655640-5x4mg 5x4mg
EUR 1590

Goat IgG isotype control
MBS176681-1mg 1mg
EUR 115

Goat IgG isotype control
MBS176681-5mg 5mg
EUR 150

Goat IgG isotype control
MBS176681-5x5mg 5x5mg
EUR 525

Rat IgG1 Isotype Control
MBS378377-05mg 0.5mg
EUR 410

Rat IgG1 Isotype Control
MBS378377-5x05mg 5x0.5mg
EUR 1550

Mouse IgM Isotype Control
abx139003-01mg 0.1 mg
EUR 376.8

Mouse IgM Isotype Control
abx020500-02mg 0.2 mg
EUR 526.8

Rat IgG2a Isotype Control
11-168-C025 0.025 mg
EUR 57.2

Rat IgG2b Isotype Control
11-169-C025 0.025 mg
EUR 57.2

Rat IgG2b Isotype Control
31R-IC001 500 ug
EUR 195
Description: Purified Rat IgG2b Isotype Control

Mouse IgM Isotype Control
abx200594-100ug 100 ug
EUR 376.8

Rat IgG2a Isotype Control
abx200644-500ug 500 ug
EUR 577.2

Rabbit Isotype Control (PE)
abx200648-100test 100 test
EUR 393.6

Rat IgG2a Isotype Control
abx405022-1ml 1 ml
EUR 360

Rat IgG2a Isotype Control
abx405024-05mg 0.5 mg
EUR 460.8

Rat IgG2a Isotype Control
abx405027-1mg 1 mg
EUR 678

Rat IgG2c Isotype Control
abx405034-025mg 0.25 mg
EUR 644.4

Rat IgG2a Isotype Control
abx405045-05mg 0.5 mg
EUR 460.8

Rat IgG2a Isotype Control
20-abx405047
  • Ask for price
  • Ask for price
  • 0.1 mg
  • 1 mg

Rat IgG2b Isotype Control
abx405051-05mg 0.5 mg
EUR 460.8

Rat IgG2b Isotype Control
20-abx405053
  • Ask for price
  • Ask for price
  • 0.1 mg
  • 1 mg

Mouse IgM Isotype Control
abx405062-100tests 100 tests
EUR 493.2

Mouse IgM Isotype Control
E2790006 100ul
EUR 225
Description: Available in various conjugation types.

Rat IgG2a Isotype Control
GWB-370B49 0.5 mg Ask for price

Mouse IgM Isotype Control
GWB-375C1A 100 TESTS Ask for price

Human IgG Isotype Control
GWB-38F945 1 ml Ask for price

Rat IgG2a Isotype Control
GWB-3C9590 0.1 mg Ask for price

Mouse IgA Isotype Control
GWB-3DF045 100 TESTS Ask for price

Human IgA Isotype Control
GWB-3FA070 1 ml Ask for price

Mouse IgM Isotype Control
GWB-401DF1 100 TESTS Ask for price

Rat IgG2a Isotype Control
GWB-423C28 0.1 mg Ask for price

Mouse IgG Isotype Control
GWB-4662CD 0.1 mg Ask for price

Mouse IgG Isotype Control
GWB-46ECA9 0.5 mg Ask for price

Rat IgG2b Isotype Control
GWB-497BCA 0.1 mg Ask for price

Mouse IgG Isotype Control
GWB-552B59 0.1 mg Ask for price

Mouse IgA Isotype Control
GWB-65FD30 0.5 mg Ask for price

Rat IgG2b Isotype Control
GWB-66906E 0.1 mg Ask for price

Rat IgG2b Isotype Control
GWB-259078 0.5 mg Ask for price

Mouse IgM Isotype Control
GWB-2B9642 1 mg Ask for price

Human IgG Isotype Control
GWB-2CF422 1.0 mg Ask for price

Mouse IgG Isotype Control
GWB-2F1CBA 0.1 mg Ask for price

Mouse IgA Isotype Control
GWB-34723E 100 TESTS Ask for price

Rat IgG2b Isotype Control
GWB-10050E 0.5 mg Ask for price

Rat IgG2b Isotype Control
GWB-11EF45 0.5 mg Ask for price

Rat IgG2b Isotype Control
GWB-15EFE0 0.5 mg Ask for price

Rat IgG2b Isotype Control
GWB-1671C8 0.5 mg Ask for price

Mouse IgG Isotype Control
GWB-1B0AB3 0.5 mg Ask for price

Mouse IgG Isotype Control
GWB-1BE5E5 10 mg Ask for price

Rat IgG2b Isotype Control
GWB-1D8308 0.1 mg Ask for price

Sheep IgG Isotype Control
GWB-1E6DA3 1 mg Ask for price

Mouse IgG Isotype Control
IC002-100ul 100ul
EUR 146.4

Mouse IgM Isotype Control
ICIGMF2-100 100 tests
EUR 396

Mouse IgM Isotype Control
ICIGMPU2-100 100 tests
EUR 396

Human IgA Isotype Control
GWB-8ADBA2 0.5 mg Ask for price

Rat IgG2a Isotype Control
GWB-8BC24F 0.1 mg Ask for price

Human IgA Isotype Control
GWB-9022E8 0.5 mg Ask for price

Mouse IgG Isotype Control
GWB-949104 0.1 mg Ask for price

Sheep IgG Isotype Control
GWB-9688FE 0.1 mg Ask for price

Human IgA Isotype Control
GWB-970C6D 1 ml Ask for price

Rat IgG2a Isotype Control
GWB-980E5C 0.1 mg Ask for price

For occasion, Electronic Health Records are normally administered by governments. Electronic Medical Records are sometimes managed by well being care suppliers, whereas Personal Health Records are managed straight by sufferers. Recently, Blockchain-based well being report programs largely regulated by know-how have emerged as one other sort of repository. Repositories for storing well being knowledge differ from each other primarily based on price, stage of safety and high quality of efficiency. Not solely has the kind of repositories elevated lately, however the quantum of well being knowledge to be saved has elevated.