Biology Cells

A content-based dataset recommendation system for researchers-a case study on Gene Expression Omnibus (GEO) repository

by
A content-based dataset recommendation system for researchers-a case study on Gene Expression Omnibus (GEO) repository

It is a rising development amongst researchers to make their knowledge publicly obtainable for experimental reproducibility and knowledge reusability. Sharing knowledge with fellow researchers helps in growing the visibility of the work. On the opposite hand, there are researchers who’re inhibited by the shortage of knowledge sources. To overcome this problem, many repositories and data bases have been established to this point to ease knowledge sharing. Further, prior to now 20 years, there was an exponential enhance within the variety of datasets added to those dataset repositories.

However, most of those repositories are domain-specific, and none of them can advocate datasets to researchers/customers. Naturally, it’s difficult for a researcher to maintain monitor of all of the related repositories for potential use. Thus, a dataset recommender system that recommends datasets to a researcher primarily based on earlier publications can improve their productiveness and expedite additional analysis. The potential to focus onto subnetworks, a number of visualizations and simulation choices will allow the AMD analysis neighborhood to computationally mannequin subnetworks or to check experimentally new hypotheses arising from connectivities in the AMD pathway map.

This work adopts an info retrieval (IR) paradigm for dataset recommendation. We hypothesize that two elementary variations exist between dataset recommendation and PubMed-style biomedical IR past the corpus. First, as an alternative of key phrases, the question is the researcher, embodied by his or her publications. Second, to filter the related datasets from non-relevant ones, researchers are higher represented by a set of pursuits, versus your entire physique of their analysis. This second strategy is applied utilizing a non-parametric clustering method.

These clusters are used to advocate datasets for every researcher utilizing the cosine similarity between the vector representations of publication clusters and datasets. The most normalized discounted cumulative acquire at 10 (NDCG@10), precision at 10 (p@10) partial and p@10 strict of 0.89, 0.78 and 0.61, respectively, have been obtained utilizing the proposed methodology after handbook analysis by 5 researchers. As per one of the best of our data, that is the primary study of its variety on content-based dataset recommendation.

Cancer PRSweb: An Online Repository with Polygenic Risk Scores for Major Cancer Traits and Their Evaluation in Two Independent Biobanks

To facilitate scientific collaboration on polygenic threat scores (PRSs) analysis, we created an intensive PRS on-line repository for 35 frequent most cancers traits integrating freely obtainable genome-wide affiliation research (GWASs) abstract statistics from three sources: printed GWASs, the NHGRI-EBI GWAS Catalog, and UK Biobank-based GWASs. Our framework condenses these abstract statistics into PRSs utilizing varied approaches comparable to linkage disequilibrium pruning/p worth thresholding (mounted or data-adaptively optimized thresholds) and penalized, genome-wide impact dimension weighting.
We evaluated the PRSs in two biobanks: the Michigan Genomics Initiative (MGI), a longitudinal biorepository effort at Michigan Medicine, and the population-based UK Biobank (UKB). For every PRS assemble, we offer measures on predictive efficiency and discrimination. Besides PRS analysis, the Cancer-PRSweb platform options assemble downloads and phenome-wide PRS affiliation study outcomes (PRS-PheWAS) for predictive PRSs. We count on this built-in platform to speed up PRS-related most cancers analysis.
This multicenter, double-blind, randomized, placebo-controlled study enrolled sufferers ≥ 18 years with lively SLE and reasonable to extreme rash and/or arthritis regardless of steady glucocorticoid doses (7.5-30 mg/day prednisone equal) and antimalarials for ≥ Four weeks and/or immunosuppressants for ≥ eight weeks earlier than screening. Stable glucocorticoid doses have been required by way of week 16 with optionally available taper from weeks 16 to 24.
Patients have been randomized (1:1) to 80 U RCI subcutaneously or placebo each different day to week 4, then twice weekly to week 24. Endpoints included the proportion of SLE Responder Index (SRI)-Four responders at week 16; modifications from baseline to week 16 in 28 Swollen Joint Count/Tender Joint Count (28 SJC/TJC) and Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI)-Activity rating; and modifications from baseline to week 24 in inflammatory cytokines. Safety was assessed by antagonistic occasions.
A content-based dataset recommendation system for researchers-a case study on Gene Expression Omnibus (GEO) repository

Advancing COVID-19 differentiation with a sturdy preprocessing and integration of multi-institutional open-repository laptop tomography datasets for deep studying evaluation

The coronavirus pandemic and its unprecedented penalties globally has spurred the curiosity of the synthetic intelligence analysis neighborhood. A plethora of printed research have investigated the position of imaging comparable to chest X-rays and laptop tomography in coronavirus illness 2019 (COVID-19) automated analysis. Οpen repositories of medical imaging knowledge can play a big position by selling cooperation amongst institutes in a world-wide scale. However, they might induce limitations associated to variable knowledge high quality and intrinsic variations because of the huge number of scanner distributors and imaging parameters.

In this study, a state-of-the-art customized U-Net mannequin is offered with a cube similarity coefficient efficiency of 99.6% together with a switch studying VGG-19 primarily based mannequin for COVID-19 versus pneumonia differentiation exhibiting an space underneath curve of 96.1%. The above was considerably improved over the baseline mannequin skilled with no segmentation in chosen tomographic slices of the identical dataset. The offered study highlights the significance of a sturdy preprocessing protocol for picture evaluation inside a heterogeneous imaging dataset and assesses the potential diagnostic worth of the offered COVID-19 mannequin by evaluating its efficiency to the state-of-the-art. Health-related knowledge is saved in various repositories which can be managed and managed by completely different entities.

Purified Chicken IgY Isotype Control
E16FCCU013-025 25 μl
EUR 541.67
Description: Available in various conjugation types.

Chicken IgY Isotype Control Antibody
MBS1564106-01mg 0.1mg
EUR 340

Chicken IgY Isotype Control Antibody
MBS1564106-5x01mg 5x0.1mg
EUR 1235

IgY, Chicken Isotype Control (HRP)
MBS655648-1mL 1mL
EUR 375

IgY, Chicken Isotype Control (HRP)
MBS655648-5x1mL 5x1mL
EUR 1530

Chicken IgG Fab fragment (isotype control, non-immune), purified
20010-Fab-1 0.5 mg
EUR 270

Chicken IgG-Fc unlabeled (isotype control, non-immune), purified
20010-3-UL 0.1 mg
EUR 242.4

Chicken IgG-HRP conjugate (isotype control, non-immune), purified
20010-1-HP 0.5 mg
EUR 270

Chicken IgG-FITC conjugate (isotype control, non-immune), purified
20010-1-F 0.5 mg
EUR 270

Chicken IgG-Biotin conjugate (isotype control, non-immune), purified
20010-1-B 0.5 mg
EUR 270

Chicken IgM-Biotin conjugate (isotype control, non-immune) purified
20010-2-1-b 0.1 mg
EUR 270

Chicken IgG-Fc-HRP conjugate (isotype control, non-immune), purified
20010-3-HP 0.1 mg
EUR 270

Chicken IgG-Fc-FITC conjugate (isotype control, non-immune), purified
20010-3-F 0.1 mg
EUR 270

Chicken IgG-Fc-Biotin conjugate (isotype control, non-immune), purified
20010-3-B 0.1 mg
EUR 270

Control Normal Chicken IgY
MBS153731-1mg 1mg
EUR 205

Control Normal Chicken IgY
MBS153731-5x1mg 5x1mg
EUR 900

Rat IgG-PE conjugate (isotype control) (Isotype control)
20005-PE 25 tests
EUR 242.4

Rat IgG-HRP conjugate (isotype control) (Isotype control)
20005-HP 100 ug
EUR 196.8

Rat IgG-FITC conjugate (isotype control) (Isotype control)
20005-F 100 ug
EUR 196.8

Rat IgG-Biotin conjugate (isotype control) (Isotype control)
20005-B 100 ug
EUR 196.8

Rabbit Isotype Control
abx200646-100ug 100 ug
EUR 393.6

Rabbit Isotype Control
IMN-001 100 µg
EUR 239.4

Rat IgG Isotype Control
31-AR15 10 mg
EUR 183
Description: Purified Rat IgG Isotype Control

Rat IgG Isotype Control
GWB-37FCE4 10 mg Ask for price

Rat IgG Isotype Control
GWB-4BFFB2 0.5 mg Ask for price

Rat IgM Isotype Control
GWB-58F247 0.1 mg Ask for price

Rat IgM Isotype Control
GWB-5EE54A 0.5 mg Ask for price

Rat IgM Isotype Control
GWB-649C16 0.5 mg Ask for price

Dog IgG Isotype Control
GWB-323C1E 5 mg Ask for price

Rat IgG Isotype Control
GWB-1E8B74 0.1 mg Ask for price

Rat IgM Isotype Control
GWB-A128B8 0.5 mg Ask for price

Rat IgM Isotype Control
GWB-A6187D 0.5 mg Ask for price

Rat IgM Isotype Control
GWB-AAC8DF 0.1 mg Ask for price

Rat IgM Isotype Control
GWB-73539C 0.5 mg Ask for price

Rat IgG Isotype Control
GWB-76BDF3 0.1 mg Ask for price

Rat IgG Isotype Control
GWB-787682 0.1 mg Ask for price

Rat IgG Isotype Control
GWB-7A6404 0.1 mg Ask for price

Rat IgG Isotype Control
GWB-F39C54 0.5 mg Ask for price

Rat IgG Isotype Control
GWB-F7A192 0.5 mg Ask for price

Rat IgG Isotype Control
GWB-B6F703 0.1 mg Ask for price

Rat IgM Isotype Control
GWB-BD20D2 0.1 mg Ask for price

Rat IgG Isotype Control
GWB-CFDA81 0.1 mg Ask for price

Rat IgM Isotype Control
GWB-D02CC7 0.1 mg Ask for price

Rat IgG Isotype Control
GWB-D9CFB7 0.1 mg Ask for price

Rat IgG Isotype Control
GWB-BEE47C 0.1 mg Ask for price

Rat IgM Isotype Control
RIGMA-100 100 µg
EUR 846.24

Rat IgM Isotype Control
RIGMB-200 200 µg
EUR 933.6

Rat IgM Isotype Control
RIGMB-50 50 µg
EUR 304.61

Rat IgM Isotype Control
RIGMF-200 200 µg
EUR 933.6

Rat IgM Isotype Control
RIGMF-50 50 µg
EUR 304.61

Rat IgM Isotype Control
RIGMPE-100 100 µg
EUR 549.22

Rat IgM Isotype Control
RIGMPE-25 25 µg
EUR 287.14

Rat IgM Isotype Control
RIGMPP5.5-25 25 µg
EUR 426.91

Rat IgM Isotype Control
RIGMPU-50 50 µg
EUR 217.25

Rat IgM Isotype Control
RIGMPU-500 500 µg
EUR 479.33

IgG, Rat Isotype Control
MBS655490-5mg 5mg
EUR 395

IgG, Rat Isotype Control
MBS655490-5x5mg 5x5mg
EUR 1630

IgM, Rat Isotype Control
MBS655629-05mg 0.5mg
EUR 450

IgM, Rat Isotype Control
MBS655629-5x05mg 5x0.5mg
EUR 1880

Rat IgG Isotype Control
MBS537341-10mg 10mg
EUR 380

Rat IgG Isotype Control
MBS537341-5x10mg 5x10mg
EUR 1550

Rat IgG1 Isotype Control
abx405020-05mg 0.5 mg
EUR 460.8

Rat IgG1 Isotype Control
abx405039-05mg 0.5 mg
EUR 460.8

Rat IgG1 Isotype Control
20-abx405041
  • Ask for price
  • Ask for price
  • 0.1 mg
  • 1 mg

Rat IgG1 Isotype Control
GWB-472B42 0.1 mg Ask for price

Rat IgG1 Isotype Control
GWB-473962 0.1 mg Ask for price

Rat IgG1 Isotype Control
GWB-62835E 0.1 mg Ask for price

Rat IgG1 Isotype Control
GWB-655784 0.5 mg Ask for price

Rat IgG1 Isotype Control
GWB-206FB5 0.1 mg Ask for price

Goat IgG Isotype Control
GWB-224618 10 mg Ask for price

Rat IgG1 Isotype Control
GWB-1672AF 0.1 mg Ask for price

Goat IgG Isotype Control
GWB-1D14C3 100 TESTS Ask for price

Rat IgG1 Isotype Control
GWB-1D80D3 0.5 mg Ask for price

Goat IgG Isotype Control
GWB-9C0B03 100 TESTS Ask for price

Rat IgG1 Isotype Control
GWB-7404ED 0.5 mg Ask for price

Goat IgG Isotype Control
GWB-7B95C3 0.5 mg Ask for price

Rat IgG1 Isotype Control
GWB-7E930C 0.1 mg Ask for price

Goat IgG Isotype Control
GWB-B5EB81 100 TESTS Ask for price

Rat IgG1 Isotype Control
GWB-B963FB 0.5 mg Ask for price

Rat IgG1 Isotype Control
GWB-DFED32 0.1 mg Ask for price

Goat IgG Isotype Control
GWB-E035B6 100 TESTS Ask for price

Goat IgG Isotype Control
GWB-D15A0C 100 TESTS Ask for price

Rat IgG1 Isotype Control
RIGG1A-100 100 µg
EUR 654.05

Rat IgG1 Isotype Control
RIGG1A-25 25 µg
EUR 322.08

Rat IgG1 Isotype Control
RIGG1F-50 50 µg
EUR 357.02

Rat IgG1 Isotype Control
RIGG1F-500 500 µg
EUR 1055.9

Rat IgG1 Isotype Control
RIGG1PE-100 100 µg
EUR 636.58

Rat IgG1 Isotype Control
RIGG1PE-25 25 µg
EUR 304.61

Rat IgG1 Isotype Control
RIGG1PP5.5-100 100 µg
EUR 706.46

Rat IgG1 Isotype Control
RIGG1PP5.5-25 25 µg
EUR 322.08

Rat IgG1 Isotype Control
RIGG1PU-50 50 µg
EUR 217.25

Rat IgG1 Isotype Control
RIGG1PU-500 500 µg
EUR 479.33

Rat IgG1 Isotype Control
abx405039-100g 100 µg
EUR 275

Rat IgG1 Isotype Control
abx405041-100g 100 µg
EUR 200

IgG1, Rat Isotype Control
MBS655540-05mg 0.5mg
EUR 420

IgG1, Rat Isotype Control
MBS655540-5x05mg 5x0.5mg
EUR 1730

IgG, Goat Isotype Control
MBS655594-5mg 5mg
EUR 370

IgG, Goat Isotype Control
MBS655594-5x5mg 5x5mg
EUR 1505

IgG, Goat Isotype Control
MBS655640-4mg 4mg
EUR 385

IgG, Goat Isotype Control
MBS655640-5x4mg 5x4mg
EUR 1590

Goat IgG isotype control
MBS176681-1mg 1mg
EUR 115

Goat IgG isotype control
MBS176681-5mg 5mg
EUR 150

Goat IgG isotype control
MBS176681-5x5mg 5x5mg
EUR 525

Rat IgG1 Isotype Control
MBS378377-05mg 0.5mg
EUR 410

Rat IgG1 Isotype Control
MBS378377-5x05mg 5x0.5mg
EUR 1550

Mouse IgM Isotype Control
abx139003-01mg 0.1 mg
EUR 376.8

Mouse IgM Isotype Control
abx020500-02mg 0.2 mg
EUR 526.8

Rat IgG2a Isotype Control
11-168-C025 0.025 mg
EUR 57.2

Rat IgG2b Isotype Control
11-169-C025 0.025 mg
EUR 57.2

Rat IgG2b Isotype Control
31R-IC001 500 ug
EUR 195
Description: Purified Rat IgG2b Isotype Control

Mouse IgM Isotype Control
abx200594-100ug 100 ug
EUR 376.8

Rat IgG2a Isotype Control
abx200644-500ug 500 ug
EUR 577.2

Rabbit Isotype Control (PE)
abx200648-100test 100 test
EUR 393.6

Rat IgG2a Isotype Control
abx405022-1ml 1 ml
EUR 360

Rat IgG2a Isotype Control
abx405024-05mg 0.5 mg
EUR 460.8

Rat IgG2a Isotype Control
abx405027-1mg 1 mg
EUR 678

Rat IgG2c Isotype Control
abx405034-025mg 0.25 mg
EUR 644.4

Rat IgG2a Isotype Control
abx405045-05mg 0.5 mg
EUR 460.8

Rat IgG2a Isotype Control
20-abx405047
  • Ask for price
  • Ask for price
  • 0.1 mg
  • 1 mg

Rat IgG2b Isotype Control
abx405051-05mg 0.5 mg
EUR 460.8

Rat IgG2b Isotype Control
20-abx405053
  • Ask for price
  • Ask for price
  • 0.1 mg
  • 1 mg

Mouse IgM Isotype Control
abx405062-100tests 100 tests
EUR 493.2

Mouse IgM Isotype Control
E2790006 100ul
EUR 225
Description: Available in various conjugation types.

Rat IgG2a Isotype Control
GWB-370B49 0.5 mg Ask for price

Mouse IgM Isotype Control
GWB-375C1A 100 TESTS Ask for price

Human IgG Isotype Control
GWB-38F945 1 ml Ask for price

Rat IgG2a Isotype Control
GWB-3C9590 0.1 mg Ask for price

Mouse IgA Isotype Control
GWB-3DF045 100 TESTS Ask for price

Human IgA Isotype Control
GWB-3FA070 1 ml Ask for price

Mouse IgM Isotype Control
GWB-401DF1 100 TESTS Ask for price

Rat IgG2a Isotype Control
GWB-423C28 0.1 mg Ask for price

Mouse IgG Isotype Control
GWB-4662CD 0.1 mg Ask for price

Mouse IgG Isotype Control
GWB-46ECA9 0.5 mg Ask for price

Rat IgG2b Isotype Control
GWB-497BCA 0.1 mg Ask for price

Mouse IgG Isotype Control
GWB-552B59 0.1 mg Ask for price

Mouse IgA Isotype Control
GWB-65FD30 0.5 mg Ask for price

Rat IgG2b Isotype Control
GWB-66906E 0.1 mg Ask for price

Rat IgG2b Isotype Control
GWB-259078 0.5 mg Ask for price

Mouse IgM Isotype Control
GWB-2B9642 1 mg Ask for price

Human IgG Isotype Control
GWB-2CF422 1.0 mg Ask for price

Mouse IgG Isotype Control
GWB-2F1CBA 0.1 mg Ask for price

Mouse IgA Isotype Control
GWB-34723E 100 TESTS Ask for price

Rat IgG2b Isotype Control
GWB-10050E 0.5 mg Ask for price

Rat IgG2b Isotype Control
GWB-11EF45 0.5 mg Ask for price

Rat IgG2b Isotype Control
GWB-15EFE0 0.5 mg Ask for price

Rat IgG2b Isotype Control
GWB-1671C8 0.5 mg Ask for price

Mouse IgG Isotype Control
GWB-1B0AB3 0.5 mg Ask for price

Mouse IgG Isotype Control
GWB-1BE5E5 10 mg Ask for price

Rat IgG2b Isotype Control
GWB-1D8308 0.1 mg Ask for price

Sheep IgG Isotype Control
GWB-1E6DA3 1 mg Ask for price

Mouse IgG Isotype Control
IC002-100ul 100ul
EUR 146.4

Mouse IgM Isotype Control
ICIGMF2-100 100 tests
EUR 396

Mouse IgM Isotype Control
ICIGMPU2-100 100 tests
EUR 396

Human IgA Isotype Control
GWB-8ADBA2 0.5 mg Ask for price

Rat IgG2a Isotype Control
GWB-8BC24F 0.1 mg Ask for price

Human IgA Isotype Control
GWB-9022E8 0.5 mg Ask for price

Mouse IgG Isotype Control
GWB-949104 0.1 mg Ask for price

Sheep IgG Isotype Control
GWB-9688FE 0.1 mg Ask for price

Human IgA Isotype Control
GWB-970C6D 1 ml Ask for price

Rat IgG2a Isotype Control
GWB-980E5C 0.1 mg Ask for price

For occasion, Electronic Health Records are normally administered by governments. Electronic Medical Records are sometimes managed by well being care suppliers, whereas Personal Health Records are managed straight by sufferers. Recently, Blockchain-based well being report programs largely regulated by know-how have emerged as one other sort of repository. Repositories for storing well being knowledge differ from each other primarily based on price, stage of safety and high quality of efficiency. Not solely has the kind of repositories elevated lately, however the quantum of well being knowledge to be saved has elevated.