Protocol for the development of a repository of individual participant data from randomised controlled trials conducted in adult care homes (the Virtual International Care Homes Trials Archive (VICHTA))

Protocol for the development of a repository of individual participant data from randomised controlled trials conducted in adult care homes (the Virtual International Care Homes Trials Archive (VICHTA))
Approximately 418,000 folks dwell in care homes in the UK, but accessible, sturdy data on care dwelling populations and organisation are missing. This hampers our means to plan, allocate assets or stop threat. Large randomised controlled trials (RCTs) conducted in care homes provide a potential resolution. The worth of detailed data on residents’ demographics, outcomes and contextual info captured in RCTs has but to be absolutely realised. Irrespective of the intervention examined, a lot of the trial data collected overlaps in phrases of structured assessments and descriptive info.
Given the time and prices required to prospectively accumulate data in these populations, pooling anonymised RCT data into a structured repository presents profit; secondary analyses of pooled RCT data can enhance understanding of this under-researched inhabitants and improve the future trial design. This protocol describes the creation of a project-specific repository of individual participant data (IPD) from trials conducted in care homes and subsequent enlargement into a legacy dataset for wider use, to deal with the want for correct, high-quality IPD on this susceptible inhabitants.
Informed by scoping of related literature, the principal investigators of RCTs conducted in adult care homes in the UK since 2010 will probably be invited to contribute trial IPD. Contributing trialists will type a Steering Committee who will oversee data sharing and stay gatekeepers of their very own trial’s data. IPD will probably be cleaned and standardised in session with the Steering Committee for accuracy. Planned analyses embrace a comparability of pooled IPD with level estimates from administrative sources, to evaluate generalisability of RCT data to the wider care dwelling inhabitants.
We may even establish key resident traits and outcomes from inside the trial repository, which is able to inform the development of a nationwide minimal dataset for care homes. Following challenge completion, administration will migrate to the Virtual Trials Archives, forming a legacy dataset which will probably be expanded to incorporate worldwide RCTs, and will probably be accessible to the wider analysis neighborhood for analyses. Analysis of pooled IPD has the potential to tell and direct future follow, analysis and coverage at low value, enhancing the worth of current data and lowering analysis waste. We intention to create a everlasting archive for care dwelling trial data and welcome the contribution of rising trial datasets.

OGP: A Repository of Experimentally Characterized O-Glycoproteins to Facilitate Studies on O-Glycosylation

Numerous research on most cancers, biopharmaceuticals, and medical trials have necessitated complete and exact evaluation of protein O-glycosylation. However, the lack of up to date and handy databases deters the storage of and reference to rising O-glycoprotein data. To resolve this difficulty, an O-glycoprotein repository named OGP was established in this work. It was constructed with a assortment of O-glycoprotein data from completely different sources. OGP accommodates 9354 O-glycosylation websites and 11,633 site-specific O-glycans mapping to 2133 O-glycoproteins, and it’s the largest O-glycoprotein repository to date. Based on the recorded O-glycosylation websites, an O-glycosylation web site prediction instrument was developed.

The first model of OGP repository and the web site enable customers to acquire numerous O-glycoprotein-related info, equivalent to protein accession numbers, O-glycosylation websites, glycopeptide sequences, site-specific glycan constructions, experimental strategies, and potential O-glycosylation websites. To tackle the challenges posed by large-scale development, validation, and adoption of synthetic intelligence (AI) in pathology, now we have constituted a consortium of teachers, small enterprises, and pharmaceutical corporations and proposed the BIGPICTURE challenge to the Innovative Medicines Initiative.

Our imaginative and prescient is to change into the catalyst in the digital transformation of pathology by creating the first European, ethically compliant, and quality-controlled entire slide imaging platform, in which each large-scale data and AI algorithms will exist. Our mission is to develop this platform in a sustainable and inclusive means, by connecting the neighborhood of pathologists, researchers, AI builders, sufferers, and trade events primarily based on creating worth and reciprocity in use primarily based on a neighborhood mannequin as the mechanism for making certain sustainability of the platform.

Protocol for the development of a repository of individual participant data from randomised controlled trials conducted in adult care homes (the Virtual International Care Homes Trials Archive (VICHTA))

Missense3D-DB net catalogue: an atom-based evaluation and repository of 4M human protein-coding genetic variants

The interpretation of human genetic variation is one of the biggest challenges of fashionable genetics. New approaches are urgently wanted to prioritize variants, particularly these which might be uncommon or lack a definitive medical interpretation. We examined 10,136,597 human missense genetic variants from GnomAD, ClinVar and UniProt. We had been capable of carry out large-scale atom-based mapping and phenotype interpretation of 3,960,015 of these variants onto 18,874 experimental and 84,818 in home predicted three-dimensional coordinates of the human proteome.

We show that 14% of amino acid substitutions from the GnomAD database that could possibly be structurally analysed are predicted to have an effect on protein construction (n = 568,548, of which 566,439 uncommon or extraordinarily uncommon) and will, subsequently, have a but unknown disease-causing impact. Moreover, an OGP-based web site is already accessible (http://www.oglyp.org/). The web site contains 4 specifically designed and user-friendly modules: statistical evaluation, database search, web site prediction, and data submission.

Mouse IgG3 Isotype Control (FITC)

abx405036-100tests 100 tests
EUR 510

Mouse IgG3 Isotype Control (PerCP)

abx200591-100ug 100 ug
EUR 878.4

Mouse IgG3 Isotype Control Purified

11-459-C025 0.025 mg
EUR 105.6

Mouse IgG3 Isotype Control Purified

11-459-C100 0.1 mg
EUR 163.2

Mouse IgG3 isotype control, purified

20102-104 100 ug
EUR 169.2

PE mouse IgG3, κ Isotype Control

E16FMCP005K-025U 25 μg
EUR 411.67
Description: Available in various conjugation types.

FITC mouse IgG3, κ Isotype Control

E16FMCF005K-050U 50 μg
EUR 325
Description: Available in various conjugation types.

Mouse IgG3 Isotype Control (OC-515)

abx200593-100ug 100 ug
EUR 727.2

Mouse IgG3 Isotype Control (CF-Blue)

abx200592-100ug 100 ug
EUR 577.2

Biotin mouse IgG3, κ Isotype Control

E16FMCB005K-050U 50 μg
EUR 260
Description: Available in various conjugation types.

Purified mouse IgG3, κ Isotype Control

E16FMCK005K-050U 50 μg
EUR 411.67
Description: Available in various conjugation types.

Mouse IgG3-PE conjugate (isotype control)

20102-104-PE 50 Tests
EUR 242.4

Mouse IgG3-HRP conjugate (isotype control)

20102-104-HP 50 Tests
EUR 196.8

Mouse IgG3-FITC conjugate (isotype control)

20102-104-F 50 tests
EUR 196.8

NE Purified mouse IgG3, κ Isotype Control

E16FMCY005K-500U 500 μg
EUR 780
Description: Available in various conjugation types.

Mouse IgG3-Biotin conjugate (isotype control)

20102-104-B 50 Tests
EUR 196.8

Mouse IgG3 Isotype control (purified) validated fo

NG908 7 ml
EUR 245
Description: Mouse IgG3 Isotype control (purified) validated for IHC; Ready-To-Use

Mouse IgG3 Isotype control (purified) validated fo

NG908C 1 ml
EUR 285
Description: Mouse IgG3 Isotype control (purified) validated for IHC; Concentrate

Mouse IgG3-PE-Cy5 conjugate (isotype control)

20102-104-PC5 50 Tests
EUR 270

Alexa Fluor® 488 mouse IgG3, κ Isotype Control

E16FMCG005K-100U 100 μg
EUR 845
Description: Available in various conjugation types.

Alexa Fluor® 647 mouse IgG3, κ Isotype Control

E16FMCK005K-025U 25 μg
EUR 173.33
Description: Available in various conjugation types.

Mouse IgG3 Isotype Control DyLight® 488

L4-459-C100 0.1 mg
EUR 255.6

Mouse IgG3 Isotype Control DyLight® 650

L6-459-C100 0.1 mg
EUR 255.6

OPRA03551-1MG - Mouse IgG3 Kappa (κ) isotype Control

OPRA03551-1MG 1mg
EUR 249

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PE

IMSIGG3KICA1123CPE100UG each
EUR 150
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PE

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PE

IMSIGG3KICA1123CPE25UG each
EUR 55
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PE

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 APC

IMSIGG3KICA1123CAPC100UG each
EUR 150
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 APC

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 APC

IMSIGG3KICA1123CAPC25UG each
EUR 55
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 APC

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 FITC

IMSIGG3KICA1123CFITC100UG each
EUR 150
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 FITC

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 FITC

IMSIGG3KICA1123CFITC25UG each
EUR 55
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 FITC

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 AF488

IMSIGG3KICA1123CAF488100UG each
EUR 150
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 AF488

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 AF488

IMSIGG3KICA1123CAF48825UG each
EUR 55
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 AF488

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 AF647

IMSIGG3KICA1123CAF647100UG each
EUR 150
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 AF647

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 AF647

IMSIGG3KICA1123CAF64725UG each
EUR 55
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 AF647

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 ER780

IMSIGG3KICA1123CER780100UG each
EUR 150
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 ER780

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 ER780

IMSIGG3KICA1123CER78025UG each
EUR 55
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 ER780

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 EV450

IMSIGG3KICA1123CEV450100UG each
EUR 150
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 EV450

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 EV450

IMSIGG3KICA1123CEV45025UG each
EUR 55
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 EV450

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 Biotin

IMSIGG3KICA1123CBL100UG each
EUR 150
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 Biotin

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 Biotin

IMSIGG3KICA1123CBL25UG each
EUR 55
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 Biotin

Mouse IgG1 Isotype Control

abx139001-01mg 0.1 mg
EUR 376.8

Mouse IgG1 Isotype Control

abx139002-01mg 0.1 mg
EUR 376.8

Mouse IgG1 Isotype Control

abx139008-01mg 0.1 mg
EUR 376.8

Mouse IgG1 Isotype Control

abx200564-100ug 100 ug
EUR 376.8

Mouse IgG1 Isotype Control

abx405007-01mg 0.1 mg
EUR 493.2

Mouse IgG1 Isotype Control

abx405009-05mg 0.5 mg
EUR 828

Mouse IgG1 Isotype Control

abx405012-1mg 1 mg
EUR 1296

Mouse IgG1 Isotype Control

abx405064-100tests 100 tests
EUR 493.2

Mouse IgG1 Isotype Control

abx405067-05mg 0.5 mg
EUR 994.8

Mouse IgG1 Isotype Control

E2790003 100ul
EUR 225
Description: Available in various conjugation types.

Mouse IgG1 Isotype Control

ICIGG1PU-01MG 100 tests
EUR 126.5

Mouse IgG2a Isotype Control

abx139004-01mg 0.1 mg
EUR 376.8

Mouse IgG2a Isotype Control

abx139005-01mg 0.1 mg
EUR 376.8

Mouse IgG2b Isotype Control

abx139006-01mg 0.1 mg
EUR 376.8

Mouse IgG2a Isotype Control

abx139009-01mg 0.1 mg
EUR 376.8

Mouse IgG2b Isotype Control

abx139011-01mg 0.1 mg
EUR 376.8

Mouse IgG2a Isotype Control

abx200572-100ug 100 ug
EUR 376.8

Mouse IgG2b Isotype Control

abx200580-100ug 100 ug
EUR 376.8

Mouse IgG2a Isotype Control

abx405013-100tests 100 tests
EUR 493.2

Mouse IgG2a Isotype Control

abx405015-05mg 0.5 mg
EUR 828

Mouse IgG2a Isotype Control

abx405018-1mg 1 mg
EUR 1328.4

Mouse IgG2b Isotype Control

abx405056-100tests 100 tests
EUR 493.2

Mouse IgG2b Isotype Control

abx405061-1mg 1 mg
EUR 1296

Mouse IgG2a Isotype Control

abx405070-100tests 100 tests
EUR 493.2

Mouse IgG2a Isotype Control

abx405073-05mg 0.5 mg
EUR 994.8

Mouse IgG2a Isotype Control

10R-I117d 1 mg
EUR 663.6
Description: Purified Mouse IgG2a Isotype Control

Mouse IgG2a Isotype Control

E2790004 100ul
EUR 225
Description: Available in various conjugation types.

Mouse IgG2b Isotype Control

E2790005 100ul
EUR 225
Description: Available in various conjugation types.

Mouse IgG Isotype Control

IC002-100ul 100ul
EUR 146.4

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PE/Cyanine5

IMSIGG3KICA1123CPECY5100UG each
EUR 150
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PE/Cyanine5

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PE/Cyanine5

IMSIGG3KICA1123CPECY525UG each
EUR 55
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PE/Cyanine5

Mouse IgG1 Isotype Control (PE)

abx139025-01mg 0.1 mg
EUR 510

Mouse IgG1 Isotype Control (PE)

abx200566-50ug 50 ug
EUR 510

Mouse IgG1 Isotype Control PE

1P-632-C025 0.025 mg
EUR 146.4

Mouse IgG1 Isotype Control PE

1P-632-C100 0.1 mg
EUR 244.8

Mouse IgG1 Isotype Control (PE)

E2790238 100ul
EUR 225
Description: Available in various conjugation types.

PE mouse IgG1 Isotype Control

E16FMCP001-050 50 tests
EUR 235.2
Description: Available in various conjugation types.

PE mouse IgG1 Isotype Control

E16FMCP001-100 100 Tests
EUR 336
Description: Available in various conjugation types.

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PerCP/Cyanine5.5

IMSIGG3KICA1123CPERCPCY55100UG each
EUR 150
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PerCP/Cyanine5.5

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PerCP/Cyanine5.5

IMSIGG3KICA1123CPERCPCY5525UG each
EUR 55
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PerCP/Cyanine5.5

Mouse IgG1 Isotype Control (APC)

abx139022-01mg 0.1 mg
EUR 510

Mouse IgG1 Isotype Control (APC)

abx200567-50ug 50 ug
EUR 510

Mouse IgG1 Isotype Control (RPE)

abx405011-100tests 100 tests
EUR 760.8

Mouse IgG1 Isotype Control (APC)

abx405065-100tests 100 tests
EUR 493.2

Mouse IgG1 Isotype Control (RPE)

abx405069-100tests 100 tests
EUR 560.4

Mouse IgG1 Isotype Control APC

1A-632-C025 0.025 mg
EUR 146.4

Mouse IgG1 Isotype Control APC

1A-632-C100 0.1 mg
EUR 244.8

Mouse IgG1 Isotype Control (APC)

E2790221 100ul
EUR 225
Description: Available in various conjugation types.

APC mouse IgG1 Isotype Control

E16FMCA001-050 50 tests
EUR 268.67
Description: Available in various conjugation types.

APC mouse IgG1 Isotype Control

E16FMCA001-100 100 Tests
EUR 403.2
Description: Available in various conjugation types.

Mouse IgG1 Isotype Control (FITC)

abx139024-01mg 0.1 mg
EUR 460.8

Mouse IgG1 Isotype Control (FITC)

abx200565-100ug 100 ug
EUR 376.8

Mouse IgG1 Isotype Control (FITC)

abx405010-01mg 0.1 mg
EUR 610.8

Mouse IgG1 Isotype Control (FITC)

abx405068-100tests 100 tests
EUR 493.2

Mouse IgG1 Isotype Control FITC

1F-632-C025 0.025 mg
EUR 129.6

Mouse IgG1 Isotype Control FITC

1F-632-C100 0.1 mg
EUR 212.4

Mouse IgG1 Isotype Control (FITC)

E2790234 100ul
EUR 225
Description: Available in various conjugation types.

FITC mouse IgG1 Isotype Control

E16FMCF001-050 50 tests
EUR 168
Description: Available in various conjugation types.

FITC mouse IgG1 Isotype Control

E16FMCF001-100 100 Tests
EUR 268.8
Description: Available in various conjugation types.

Mouse IgG1 Isotype Control (PerCP)

abx139026-01mg 0.1 mg
EUR 560.4

Mouse IgG1 Isotype Control (PerCP)

abx200568-100ug 100 ug
EUR 510

Mouse IgG1 Isotype Control PerCP

PC-632-C025 0.025 mg
EUR 163.2

Mouse IgG1 Isotype Control PerCP

PC-632-C100 0.1 mg
EUR 277.2

Mouse IgG2a Isotype Control (PE)

abx139015-01mg 0.1 mg
EUR 510

Mouse IgG2b Isotype Control (PE)

abx139020-01mg 0.1 mg
EUR 510

Mouse IgG2a Isotype Control (PE)

abx200574-50ug 50 ug
EUR 510

Mouse IgG2b Isotype Control (PE)

abx200582-50ug 50 ug
EUR 510

Mouse IgG2b Isotype Control PE

1P-692-C025 0.025 mg
EUR 146.4

Mouse IgG2b Isotype Control PE

1P-692-C100 0.1 mg
EUR 244.8

Mouse IgG2a Isotype Control PE

1P-724-C025 0.025 mg
EUR 146.4

Mouse IgG2a Isotype Control PE

1P-724-C100 0.1 mg
EUR 244.8

Mouse IgG2a Isotype Control (PE)

E2790239 100ul
EUR 225
Description: Available in various conjugation types.

Mouse IgG2b Isotype Control (PE)

E2790240 100ul
EUR 225
Description: Available in various conjugation types.

PE mouse IgG2a Isotype Control

E16FMCP002-050 50 tests
EUR 235.2
Description: Available in various conjugation types.

PE mouse IgG2a Isotype Control

E16FMCP002-100 100 Tests
EUR 336
Description: Available in various conjugation types.

PE mouse IgG2b Isotype Control

E16FMCP003-050 50 tests
EUR 235.2
Description: Available in various conjugation types.

PE mouse IgG2b Isotype Control

E16FMCP003-100 100 Tests
EUR 336
Description: Available in various conjugation types.

Mouse IgG1 Isotype Control (Biotin)

abx139023-01mg 0.1 mg
EUR 460.8

Mouse IgG1 Isotype Control (Biotin)

abx405008-01mg 0.1 mg
EUR 610.8

Mouse IgG1 Isotype Control (Biotin)

abx405066-100tests 100 tests
EUR 493.2

Mouse IgG1 Isotype Control Biotin

1B-632-C025 0.025 mg
EUR 129.6

Mouse IgG1 Isotype Control Biotin

1B-632-C100 0.1 mg
EUR 212.4

Biotin mouse IgG1 Isotype Control

E16FMCB001-050 50 tests
EUR 168
Description: Available in various conjugation types.

Biotin mouse IgG1 Isotype Control

E16FMCB001-100 100 Tests
EUR 268.8
Description: Available in various conjugation types.

Biotin mouse IgG1 Isotype Control

E16FMCB001-100U 100 μg
EUR 268.8
Description: Available in various conjugation types.

Biotin mouse IgG1 Isotype Control

E16FMCB001-500U 500 μg
EUR 739.2
Description: Available in various conjugation types.

Mouse IgG2a Isotype Control (APC)

abx139012-01mg 0.1 mg
EUR 510

Mouse IgG2b Isotype Control (APC)

abx139017-01mg 0.1 mg
EUR 510

Mouse IgG2a Isotype Control (APC)

abx200575-50ug 50 ug
EUR 510

Mouse IgG2b Isotype Control (APC)

abx200583-50ug 50 ug
EUR 510

Mouse IgG2a Isotype Control (RPE)

abx405017-100tests 100 tests
EUR 760.8

Mouse IgG2b Isotype Control (APC)

abx405057-100tests 100 tests
EUR 577.2

the similar is true for 19.0% (n = 6266) of variants of unknown medical significance or conflicting interpretation reported in the ClinVar database. The outcomes of the structural evaluation can be found in the devoted net catalogue Missense3D-DB. For every of the four M variants, the outcomes of the structural evaluation are introduced in a pleasant concise format that may be included in medical genetic stories. An in depth report of the structural evaluation can also be accessible for the non-experts in structural biology. Population frequency and predictions from SIFT and PolyPhen are included for a extra complete variant interpretation. This is the first large-scale atom-based structural interpretation of human genetic variation and presents geneticists and the biomedical neighborhood a new method to genetic variant interpretation.

A content-based dataset recommendation system for researchers-a case study on Gene Expression Omnibus (GEO) repository

A content-based dataset recommendation system for researchers-a case study on Gene Expression Omnibus (GEO) repository

It is a rising development amongst researchers to make their knowledge publicly obtainable for experimental reproducibility and knowledge reusability. Sharing knowledge with fellow researchers helps in growing the visibility of the work. On the opposite hand, there are researchers who’re inhibited by the shortage of knowledge sources. To overcome this problem, many repositories and data bases have been established to this point to ease knowledge sharing. Further, prior to now 20 years, there was an exponential enhance within the variety of datasets added to those dataset repositories.

However, most of those repositories are domain-specific, and none of them can advocate datasets to researchers/customers. Naturally, it’s difficult for a researcher to maintain monitor of all of the related repositories for potential use. Thus, a dataset recommender system that recommends datasets to a researcher primarily based on earlier publications can improve their productiveness and expedite additional analysis. The potential to focus onto subnetworks, a number of visualizations and simulation choices will allow the AMD analysis neighborhood to computationally mannequin subnetworks or to check experimentally new hypotheses arising from connectivities in the AMD pathway map.

This work adopts an info retrieval (IR) paradigm for dataset recommendation. We hypothesize that two elementary variations exist between dataset recommendation and PubMed-style biomedical IR past the corpus. First, as an alternative of key phrases, the question is the researcher, embodied by his or her publications. Second, to filter the related datasets from non-relevant ones, researchers are higher represented by a set of pursuits, versus your entire physique of their analysis. This second strategy is applied utilizing a non-parametric clustering method.

These clusters are used to advocate datasets for every researcher utilizing the cosine similarity between the vector representations of publication clusters and datasets. The most normalized discounted cumulative acquire at 10 (NDCG@10), precision at 10 (p@10) partial and p@10 strict of 0.89, 0.78 and 0.61, respectively, have been obtained utilizing the proposed methodology after handbook analysis by 5 researchers. As per one of the best of our data, that is the primary study of its variety on content-based dataset recommendation.

Cancer PRSweb: An Online Repository with Polygenic Risk Scores for Major Cancer Traits and Their Evaluation in Two Independent Biobanks

To facilitate scientific collaboration on polygenic threat scores (PRSs) analysis, we created an intensive PRS on-line repository for 35 frequent most cancers traits integrating freely obtainable genome-wide affiliation research (GWASs) abstract statistics from three sources: printed GWASs, the NHGRI-EBI GWAS Catalog, and UK Biobank-based GWASs. Our framework condenses these abstract statistics into PRSs utilizing varied approaches comparable to linkage disequilibrium pruning/p worth thresholding (mounted or data-adaptively optimized thresholds) and penalized, genome-wide impact dimension weighting.
We evaluated the PRSs in two biobanks: the Michigan Genomics Initiative (MGI), a longitudinal biorepository effort at Michigan Medicine, and the population-based UK Biobank (UKB). For every PRS assemble, we offer measures on predictive efficiency and discrimination. Besides PRS analysis, the Cancer-PRSweb platform options assemble downloads and phenome-wide PRS affiliation study outcomes (PRS-PheWAS) for predictive PRSs. We count on this built-in platform to speed up PRS-related most cancers analysis.
This multicenter, double-blind, randomized, placebo-controlled study enrolled sufferers ≥ 18 years with lively SLE and reasonable to extreme rash and/or arthritis regardless of steady glucocorticoid doses (7.5-30 mg/day prednisone equal) and antimalarials for ≥ Four weeks and/or immunosuppressants for ≥ eight weeks earlier than screening. Stable glucocorticoid doses have been required by way of week 16 with optionally available taper from weeks 16 to 24.
Patients have been randomized (1:1) to 80 U RCI subcutaneously or placebo each different day to week 4, then twice weekly to week 24. Endpoints included the proportion of SLE Responder Index (SRI)-Four responders at week 16; modifications from baseline to week 16 in 28 Swollen Joint Count/Tender Joint Count (28 SJC/TJC) and Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI)-Activity rating; and modifications from baseline to week 24 in inflammatory cytokines. Safety was assessed by antagonistic occasions.
A content-based dataset recommendation system for researchers-a case study on Gene Expression Omnibus (GEO) repository

Advancing COVID-19 differentiation with a sturdy preprocessing and integration of multi-institutional open-repository laptop tomography datasets for deep studying evaluation

The coronavirus pandemic and its unprecedented penalties globally has spurred the curiosity of the synthetic intelligence analysis neighborhood. A plethora of printed research have investigated the position of imaging comparable to chest X-rays and laptop tomography in coronavirus illness 2019 (COVID-19) automated analysis. Οpen repositories of medical imaging knowledge can play a big position by selling cooperation amongst institutes in a world-wide scale. However, they might induce limitations associated to variable knowledge high quality and intrinsic variations because of the huge number of scanner distributors and imaging parameters.

In this study, a state-of-the-art customized U-Net mannequin is offered with a cube similarity coefficient efficiency of 99.6% together with a switch studying VGG-19 primarily based mannequin for COVID-19 versus pneumonia differentiation exhibiting an space underneath curve of 96.1%. The above was considerably improved over the baseline mannequin skilled with no segmentation in chosen tomographic slices of the identical dataset. The offered study highlights the significance of a sturdy preprocessing protocol for picture evaluation inside a heterogeneous imaging dataset and assesses the potential diagnostic worth of the offered COVID-19 mannequin by evaluating its efficiency to the state-of-the-art. Health-related knowledge is saved in various repositories which can be managed and managed by completely different entities.

Chicken IgG-FITC conjugate (isotype control, non-immune), purified

20010-1-F 0.5 mg
EUR 270

Chicken IgG-Biotin conjugate (isotype control, non-immune), purified

20010-1-B 0.5 mg
EUR 270

Chicken IgM-Biotin conjugate (isotype control, non-immune) purified

20010-2-1-b 0.1 mg
EUR 270

Chicken IgG-Fc-HRP conjugate (isotype control, non-immune), purified

20010-3-HP 0.1 mg
EUR 270

Chicken IgG-Fc-FITC conjugate (isotype control, non-immune), purified

20010-3-F 0.1 mg
EUR 270

Chicken IgG-Fc-Biotin conjugate (isotype control, non-immune), purified

20010-3-B 0.1 mg
EUR 270

Rat IgG-PE conjugate (isotype control) (Isotype control)

20005-PE 25 tests
EUR 242.4

Rat IgG-HRP conjugate (isotype control) (Isotype control)

20005-HP 100 ug
EUR 196.8

Rat IgG-FITC conjugate (isotype control) (Isotype control)

20005-F 100 ug
EUR 196.8

Rat IgG-Biotin conjugate (isotype control) (Isotype control)

20005-B 100 ug
EUR 196.8

Rabbit Isotype Control

abx200646-100ug 100 ug
EUR 393.6

Rabbit Isotype Control

IMN-001 100 µg
EUR 239.4

Rat IgG Isotype Control

31-AR15 10 mg
EUR 264
Description: Purified Rat IgG Isotype Control

Rat IgM Isotype Control

RIGMA-100 100 µg
EUR 846.24

Rat IgM Isotype Control

RIGMB-200 200 µg
EUR 933.6

Rat IgM Isotype Control

RIGMB-50 50 µg
EUR 304.61

Rat IgM Isotype Control

RIGMF-200 200 µg
EUR 933.6

Rat IgM Isotype Control

RIGMF-50 50 µg
EUR 304.61

Rat IgM Isotype Control

RIGMPE-100 100 µg
EUR 549.22

Rat IgM Isotype Control

RIGMPE-25 25 µg
EUR 287.14

Rat IgM Isotype Control

RIGMPP5.5-25 25 µg
EUR 426.91

Rat IgM Isotype Control

RIGMPU-50 50 µg
EUR 217.25

Rat IgM Isotype Control

RIGMPU-500 500 µg
EUR 479.33

Rat IgG1 Isotype Control

abx405020-05mg 0.5 mg
EUR 460.8

Rat IgG1 Isotype Control

abx405039-05mg 0.5 mg
EUR 460.8

Rat IgG1 Isotype Control

20-abx405041
  • EUR 360.00
  • EUR 526.80
  • 0.1 mg
  • 1 mg

Rat IgG1 Isotype Control

RIGG1A-100 100 µg
EUR 654.05

Rat IgG1 Isotype Control

RIGG1A-25 25 µg
EUR 322.08

Rat IgG1 Isotype Control

RIGG1F-50 50 µg
EUR 357.02

Rat IgG1 Isotype Control

RIGG1F-500 500 µg
EUR 1055.9

Rat IgG1 Isotype Control

RIGG1PE-100 100 µg
EUR 636.58

Rat IgG1 Isotype Control

RIGG1PE-25 25 µg
EUR 304.61

Rat IgG1 Isotype Control

RIGG1PP5.5-100 100 µg
EUR 706.46

Rat IgG1 Isotype Control

RIGG1PP5.5-25 25 µg
EUR 322.08

Rat IgG1 Isotype Control

RIGG1PU-50 50 µg
EUR 217.25

Rat IgG1 Isotype Control

RIGG1PU-500 500 µg
EUR 479.33

Mouse IgM Isotype Control

abx139003-01mg 0.1 mg
EUR 376.8

Mouse IgM Isotype Control

abx200594-100ug 100 ug
EUR 376.8

Rat IgG2a Isotype Control

abx200644-500ug 500 ug
EUR 577.2

Rabbit Isotype Control (PE)

abx200648-100test 100 test
EUR 393.6

Rat IgG2a Isotype Control

abx405022-1ml 1 ml
EUR 360

Rat IgG2a Isotype Control

abx405024-05mg 0.5 mg
EUR 460.8

Rat IgG2a Isotype Control

abx405027-1mg 1 mg
EUR 678

Rat IgG2c Isotype Control

abx405034-025mg 0.25 mg
EUR 644.4

Rat IgG2a Isotype Control

abx405045-05mg 0.5 mg
EUR 460.8

Rat IgG2a Isotype Control

20-abx405047
  • EUR 360.00
  • EUR 526.80
  • 0.1 mg
  • 1 mg

Rat IgG2b Isotype Control

abx405051-05mg 0.5 mg
EUR 460.8

Rat IgG2b Isotype Control

20-abx405053
  • EUR 360.00
  • EUR 526.80
  • 0.1 mg
  • 1 mg

Mouse IgM Isotype Control

abx405062-100tests 100 tests
EUR 493.2

Rat IgG2a Isotype Control

11-168-C025 0.025 mg
EUR 104.4

Rat IgG2b Isotype Control

11-169-C025 0.025 mg
EUR 104.4

Mouse IgM Isotype Control

abx020500-02mg 0.2 mg
EUR 526.8

Rat IgG2b Isotype Control

31R-IC001 500 ug
EUR 289.2
Description: Purified Rat IgG2b Isotype Control

Mouse IgG Isotype Control

IC002-100ul 100ul
EUR 146.4

Mouse IgM Isotype Control

E2790006 100ul
EUR 225
Description: Available in various conjugation types.

Mouse IgM Isotype Control

ICIGMF2-100 100 tests
EUR 396

Mouse IgM Isotype Control

ICIGMPU2-100 100 tests
EUR 396

Rat IgG2a Isotype Control

RIGG2AA-100 100 µg
EUR 374.5

Rat IgG2a Isotype Control

RIGG2AA-25 25 µg
EUR 217.25

Rat IgG2a Isotype Control

RIGG2AB-200 200 µg
EUR 549.22

Rat IgG2a Isotype Control

RIGG2AB-50 50 µg
EUR 269.66

Rat IgG2a Isotype Control

RIGG2AF-200 200 µg
EUR 374.5

Rat IgG2a Isotype Control

RIGG2AF-50 50 µg
EUR 199.78

Rat IgG2a Isotype Control

RIGG2APE-100 100 µg
EUR 339.55

Rat IgG2a Isotype Control

RIGG2APE-25 25 µg
EUR 199.78

Rat IgG2a Isotype Control

RIGG2APP-100 100 µg
EUR 688.99

Rat IgG2a Isotype Control

RIGG2APP-25 25 µg
EUR 322.08

Rat IgG2a Isotype Control

RIGG2APP5.5-100 100 µg
EUR 776.35

Rat IgG2a Isotype Control

RIGG2APP5.5-25 25 µg
EUR 339.55

Rat IgG2a Isotype Control

RIGG2APU-50 50 µg
EUR 217.25

Rat IgG2a Isotype Control

RIGG2APU-500 500 µg
EUR 479.33

Rat IgG2b Isotype Control

RIGG2BA-100 100 µg
EUR 391.97

Rat IgG2b Isotype Control

RIGG2BA-25 25 µg
EUR 199.78

Rat IgG2b Isotype Control

RIGG2BB-200 200 µg
EUR 549.22

Rat IgG2b Isotype Control

RIGG2BB-50 50 µg
EUR 269.66

Rat IgG2b Isotype Control

RIGG2BF-200 200 µg
EUR 566.69

Rat IgG2b Isotype Control

RIGG2BF-50 50 µg
EUR 182.3

Rat IgG2b Isotype Control

RIGG2BPE-100 100 µg
EUR 322.08

Rat IgG2b Isotype Control

RIGG2BPE-25 25 µg
EUR 182.3

Rat IgG2b Isotype Control

RIGG2BPP-100 100 µg
EUR 688.99

Rat IgG2b Isotype Control

RIGG2BPP-25 25 µg
EUR 322.08

Rat IgG2b Isotype Control

RIGG2BPP5.5-100 100 µg
EUR 619.1

Rat IgG2b Isotype Control

RIGG2BPP5.5-25 25 µg
EUR 339.55

Rat IgG2b Isotype Control

RIGG2BPU-50 50 µg
EUR 147.36

Rat IgG2b Isotype Control

RIGG2BPU-500 500 µg
EUR 444.38

Rat IgG2c Isotype Control

RIGG2CA-25 25 µg
EUR 304.61

Rat IgG2c Isotype Control

RIGG2CB-50 50 µg
EUR 269.66

Rat IgG2c Isotype Control

RIGG2CF-50 50 µg
EUR 304.61

Rat IgG2c Isotype Control

RIGG2CPE-25 25 µg
EUR 287.14

Rat IgG2c Isotype Control

RIGG2CPP5.5-25 25 µg
EUR 339.55

Rat IgG2c Isotype Control

RIGG2CPU-50 50 µg
EUR 217.25

Rat IgG2c Isotype Control

RIGG2CPU-500 500 µg
EUR 479.33

Mouse IgG1 Isotype Control

abx139001-01mg 0.1 mg
EUR 376.8

Mouse IgG1 Isotype Control

abx139002-01mg 0.1 mg
EUR 376.8

Mouse IgG1 Isotype Control

abx139008-01mg 0.1 mg
EUR 376.8

Mouse IgG3 Isotype Control

abx139010-01mg 0.1 mg
EUR 376.8

Mouse IgG1 Isotype Control

abx200564-100ug 100 ug
EUR 376.8

Mouse IgG3 Isotype Control

abx200587-100ug 100 ug
EUR 427.2

Mouse IgG1 Isotype Control

abx405007-01mg 0.1 mg
EUR 493.2

Mouse IgG1 Isotype Control

abx405009-05mg 0.5 mg
EUR 828

Mouse IgG1 Isotype Control

abx405012-1mg 1 mg
EUR 1296

Mouse IgG3 Isotype Control

abx405035-01mg 0.1 mg
EUR 493.2

Mouse IgG1 Isotype Control

abx405064-100tests 100 tests
EUR 493.2

Mouse IgG1 Isotype Control

abx405067-05mg 0.5 mg
EUR 994.8

Rabbit IgG Isotype Control

abx125003-100ul 100 ul
EUR 243.6

Rabbit IgG Isotype Control

IC001-100ul 100ul
EUR 146.4

Rabbit IgG isotype control

AC042 100μL
EUR 292.5
Description: None

Mouse IgG1 Isotype Control

E2790003 100ul
EUR 225
Description: Available in various conjugation types.

Mouse IgG1 Isotype Control

ICIGG1PU-01MG 100 tests
EUR 126.5

human IgG1 ( ()-isotype) control

E4A11C02 50ug
EUR 255
Description: Available in various conjugation types.

Mouse IgG2a Isotype Control

abx139004-01mg 0.1 mg
EUR 376.8

Mouse IgG2a Isotype Control

abx139005-01mg 0.1 mg
EUR 376.8

Mouse IgG2b Isotype Control

abx139006-01mg 0.1 mg
EUR 376.8

Mouse IgG2a Isotype Control

abx139009-01mg 0.1 mg
EUR 376.8

Mouse IgG2b Isotype Control

abx139011-01mg 0.1 mg
EUR 376.8

Mouse IgG2a Isotype Control

abx200572-100ug 100 ug
EUR 376.8

Mouse IgG2b Isotype Control

abx200580-100ug 100 ug
EUR 376.8

Rabbit Isotype Control (FITC)

abx200647-100test 100 test
EUR 393.6

Mouse IgG2a Isotype Control

abx405013-100tests 100 tests
EUR 493.2

Mouse IgG2a Isotype Control

abx405015-05mg 0.5 mg
EUR 828

Mouse IgG2a Isotype Control

abx405018-1mg 1 mg
EUR 1328.4

Mouse IgG2b Isotype Control

abx405056-100tests 100 tests
EUR 493.2

Mouse IgG2b Isotype Control

abx405061-1mg 1 mg
EUR 1296

Mouse IgG2a Isotype Control

abx405070-100tests 100 tests
EUR 493.2

Mouse IgG2a Isotype Control

abx405073-05mg 0.5 mg
EUR 994.8

Mouse IgG2a Isotype Control

10R-I117d 1 mg
EUR 663.6
Description: Purified Mouse IgG2a Isotype Control

Mouse IgG2a Isotype Control

E2790004 100ul
EUR 225
Description: Available in various conjugation types.

Mouse IgG2b Isotype Control

E2790005 100ul
EUR 225
Description: Available in various conjugation types.

IgG Isotype Control antibody

10R-6524 50 ug
EUR 159.6
Description: Armenian Hamster monoclonal IgG Isotype Control antibody

IgG Isotype Control antibody

10R-6525 50 ug
EUR 159.6
Description: Syrian Hamster monoclonal IgG Isotype Control antibody

PE rat IgG1, Isotype Control

E16FRCP001-025U 25 μg
EUR 303.33
Description: Available in various conjugation types.

PE rat IgG1, Isotype Control

E16FRCP001-100U 100 μg
EUR 715
Description: Available in various conjugation types.

PE Goat IgG Isotype Control

E16FGCP006-100 100 tests
EUR 368.33
Description: Available in various conjugation types.

Mouse IgM Isotype Control (PE)

abx139032-01mg 0.1 mg
EUR 510

Rat IgG1 Isotype Control (RPE)

abx405042-100tests 100 tests
EUR 427.2

Rat IgG2a Isotype Control PE

1P-168-C025 0.025 mg
EUR 146.4

Rat IgG2a Isotype Control PE

1P-168-C100 0.1 mg
EUR 244.8

Mouse IgM Isotype Control PE

1P-803-C025 0.025 mg
EUR 146.4

Mouse IgM Isotype Control PE

1P-803-C100 0.1 mg
EUR 244.8

Mouse IgM Isotype Control (PE)

E2790001 100ul
EUR 225
Description: Available in various conjugation types.

PE mouse IgM Isotype Control

E16FMCP004-050 50 tests
EUR 235.2
Description: Available in various conjugation types.

PE mouse IgM Isotype Control

E16FMCP004-100 100 Tests
EUR 336
Description: Available in various conjugation types.

APC rat IgG1, Isotype Control

E16FRCA001-025U 25 μg
EUR 325
Description: Available in various conjugation types.

APC rat IgG1, Isotype Control

E16FRCA001-100U 100 μg
EUR 736.67
Description: Available in various conjugation types.

Rat IgG2b Isotype Control PE

1P-169-C100 0.1mg
EUR 198

Mouse IgG1 Isotype Control (PE)

abx139025-01mg 0.1 mg
EUR 510

Mouse IgG1 Isotype Control (PE)

abx200566-50ug 50 ug
EUR 510

Mouse IgG3 Isotype Control (PE)

abx200589-50ug 50 ug
EUR 727.2

Rat IgG1 Isotype Control (FITC)

abx200645-200ug 200 ug
EUR 661.2

Rat IgG1 Isotype Control (FITC)

abx405021-100tests 100 tests
EUR 410.4

Rat IgG2a Isotype Control (RPE)

abx405026-100tests 100 tests
EUR 427.2

Rat IgG1 Isotype Control (FITC)

abx405040-01mg 0.1 mg
EUR 410.4

Rat IgG2a Isotype Control (APC)

abx405043-100tests 100 tests
EUR 510

Rat IgG2a Isotype Control (RPE)

abx405048-100tests 100 tests
EUR 427.2

Rat IgG2b Isotype Control (APC)

abx405049-100tests 100 tests
EUR 510

Rat IgG2b Isotype Control (RPE)

abx405055-100tests 100 tests
EUR 427.2

Mouse IgG1 Isotype Control PE

1P-632-C025 0.025 mg
EUR 146.4

Mouse IgG1 Isotype Control PE

1P-632-C100 0.1 mg
EUR 244.8

Mouse IgM Isotype Control (APC)

E2790224 100ul
EUR 225
Description: Available in various conjugation types.

Mouse IgG1 Isotype Control (PE)

E2790238 100ul
EUR 225
Description: Available in various conjugation types.

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