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Protocol for the development of a repository of individual participant data from randomised controlled trials conducted in adult care homes (the Virtual International Care Homes Trials Archive (VICHTA))

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Protocol for the development of a repository of individual participant data from randomised controlled trials conducted in adult care homes (the Virtual International Care Homes Trials Archive (VICHTA))
Approximately 418,000 folks dwell in care homes in the UK, but accessible, sturdy data on care dwelling populations and organisation are missing. This hampers our means to plan, allocate assets or stop threat. Large randomised controlled trials (RCTs) conducted in care homes provide a potential resolution. The worth of detailed data on residents’ demographics, outcomes and contextual info captured in RCTs has but to be absolutely realised. Irrespective of the intervention examined, a lot of the trial data collected overlaps in phrases of structured assessments and descriptive info.
Given the time and prices required to prospectively accumulate data in these populations, pooling anonymised RCT data into a structured repository presents profit; secondary analyses of pooled RCT data can enhance understanding of this under-researched inhabitants and improve the future trial design. This protocol describes the creation of a project-specific repository of individual participant data (IPD) from trials conducted in care homes and subsequent enlargement into a legacy dataset for wider use, to deal with the want for correct, high-quality IPD on this susceptible inhabitants.
Informed by scoping of related literature, the principal investigators of RCTs conducted in adult care homes in the UK since 2010 will probably be invited to contribute trial IPD. Contributing trialists will type a Steering Committee who will oversee data sharing and stay gatekeepers of their very own trial’s data. IPD will probably be cleaned and standardised in session with the Steering Committee for accuracy. Planned analyses embrace a comparability of pooled IPD with level estimates from administrative sources, to evaluate generalisability of RCT data to the wider care dwelling inhabitants.
We may even establish key resident traits and outcomes from inside the trial repository, which is able to inform the development of a nationwide minimal dataset for care homes. Following challenge completion, administration will migrate to the Virtual Trials Archives, forming a legacy dataset which will probably be expanded to incorporate worldwide RCTs, and will probably be accessible to the wider analysis neighborhood for analyses. Analysis of pooled IPD has the potential to tell and direct future follow, analysis and coverage at low value, enhancing the worth of current data and lowering analysis waste. We intention to create a everlasting archive for care dwelling trial data and welcome the contribution of rising trial datasets.

OGP: A Repository of Experimentally Characterized O-Glycoproteins to Facilitate Studies on O-Glycosylation

Numerous research on most cancers, biopharmaceuticals, and medical trials have necessitated complete and exact evaluation of protein O-glycosylation. However, the lack of up to date and handy databases deters the storage of and reference to rising O-glycoprotein data. To resolve this difficulty, an O-glycoprotein repository named OGP was established in this work. It was constructed with a assortment of O-glycoprotein data from completely different sources. OGP accommodates 9354 O-glycosylation websites and 11,633 site-specific O-glycans mapping to 2133 O-glycoproteins, and it’s the largest O-glycoprotein repository to date. Based on the recorded O-glycosylation websites, an O-glycosylation web site prediction instrument was developed.

The first model of OGP repository and the web site enable customers to acquire numerous O-glycoprotein-related info, equivalent to protein accession numbers, O-glycosylation websites, glycopeptide sequences, site-specific glycan constructions, experimental strategies, and potential O-glycosylation websites. To tackle the challenges posed by large-scale development, validation, and adoption of synthetic intelligence (AI) in pathology, now we have constituted a consortium of teachers, small enterprises, and pharmaceutical corporations and proposed the BIGPICTURE challenge to the Innovative Medicines Initiative.

Our imaginative and prescient is to change into the catalyst in the digital transformation of pathology by creating the first European, ethically compliant, and quality-controlled entire slide imaging platform, in which each large-scale data and AI algorithms will exist. Our mission is to develop this platform in a sustainable and inclusive means, by connecting the neighborhood of pathologists, researchers, AI builders, sufferers, and trade events primarily based on creating worth and reciprocity in use primarily based on a neighborhood mannequin as the mechanism for making certain sustainability of the platform.

Protocol for the development of a repository of individual participant data from randomised controlled trials conducted in adult care homes (the Virtual International Care Homes Trials Archive (VICHTA))

Missense3D-DB net catalogue: an atom-based evaluation and repository of 4M human protein-coding genetic variants

The interpretation of human genetic variation is one of the biggest challenges of fashionable genetics. New approaches are urgently wanted to prioritize variants, particularly these which might be uncommon or lack a definitive medical interpretation. We examined 10,136,597 human missense genetic variants from GnomAD, ClinVar and UniProt. We had been capable of carry out large-scale atom-based mapping and phenotype interpretation of 3,960,015 of these variants onto 18,874 experimental and 84,818 in home predicted three-dimensional coordinates of the human proteome.

We show that 14% of amino acid substitutions from the GnomAD database that could possibly be structurally analysed are predicted to have an effect on protein construction (n = 568,548, of which 566,439 uncommon or extraordinarily uncommon) and will, subsequently, have a but unknown disease-causing impact. Moreover, an OGP-based web site is already accessible (http://www.oglyp.org/). The web site contains 4 specifically designed and user-friendly modules: statistical evaluation, database search, web site prediction, and data submission.

Mouse IgG3 Isotype Control
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Mouse IgG3 Isotype Control
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EUR 250

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Mouse IgG3 Isotype Control
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Mouse IgG3 Isotype Control
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EUR 410

Mouse IgG3 Isotype Control
MBS378380-5x05mg 5x0.5mg
EUR 1550

Mouse IgG3 Isotype Control PE
1P-459-C100 0.1mg
EUR 198

Mouse IgG3 Isotype Control (PE)
abx200589-50ug 50 ug
EUR 727.2

Mouse IgG3 Isotype Control (PE)
abx405037-100g 100 µg
EUR 350

Mouse IgG3 Isotype Control (PE)
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Mouse IgG3 Isotype Control (PE)
abx347128-20g 20 µg
EUR 350

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abx347128-50g 50 µg Ask for price

Mouse IgG3 Isotype Control PE
MBS1801917-01mg 0.1mg
EUR 305

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MBS1801917-5x01mg 5x0.1mg
EUR 1120

Mouse IgG3 Isotype Control (APC)
abx200590-100ug 100 ug
EUR 878.4

Mouse IgG3 Isotype Control (RPE)
abx405037-100tests 100 tests
EUR 510

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abx200588-100ug 100 ug
EUR 477.6

Mouse IgG3 Isotype Control (FITC)
abx405036-100tests 100 tests
EUR 510

Mouse IgG3 Isotype Control (FITC)
abx405036-100g 100 µg
EUR 350

Mouse IgG3 Isotype Control (PerCP)
abx200591-100ug 100 ug
EUR 878.4

Mouse IgG3 Isotype Control (DL488)
abx140587-100g 100 µg
EUR 362.5

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abx140588-100g 100 µg
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11-459-C025 0.025 mg
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Mouse IgG3 isotype control, purified
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EUR 169.2

Mouse IgG3 Isotype Control Purified
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EUR 235

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EUR 825

Mouse IgG3 Isotype Control DyLight488
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EUR 1175

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MBS1801491-01mg 0.1mg
EUR 315

Mouse IgG3 Isotype Control DyLight650
MBS1801491-5x01mg 5x0.1mg
EUR 1175

PE mouse IgG3, κ Isotype Control
E16FMCP005K-025U 25 μg
EUR 411.67
Description: Available in various conjugation types.

PE Mouse IgG3, κ Isotype Control
RD30024F-100Tests 100Tests
EUR 123

PE Mouse IgG3, κ Isotype Control
RD30024F-100Testsx2 100Testsx2
EUR 168

PE Mouse IgG3, κ Isotype Control
RD30024F-20Tests 20Tests
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PE Mouse IgG3, κ Isotype Control
RD30035F-100ug 100μg
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PE Mouse IgG3, κ Isotype Control
RD30035F-25ug 25μg
EUR 31.5

APC Mouse IgG3, κ Isotype Control
RD30025F-100Tests 100Tests
EUR 165

APC Mouse IgG3, κ Isotype Control
RD30025F-100Testsx2 100Testsx2
EUR 240

APC Mouse IgG3, κ Isotype Control
RD30025F-20Tests 20Tests
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APC Mouse IgG3, κ Isotype Control
RD30036F-100ug 100μg
EUR 103.5

APC Mouse IgG3, κ Isotype Control
RD30036F-25ug 25μg
EUR 45

FITC mouse IgG3, κ Isotype Control
E16FMCF005K-050U 50 μg
EUR 325
Description: Available in various conjugation types.

FITC Mouse IgG3, κ Isotype Control
RD30023F-100Tests 100Tests
EUR 123

FITC Mouse IgG3, κ Isotype Control
RD30023F-100Testsx2 100Testsx2
EUR 168

FITC Mouse IgG3, κ Isotype Control
RD30023F-20Tests 20Tests
EUR 48

FITC Mouse IgG3, κ Isotype Control
RD30034F-100ug 100μg
EUR 75

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RD30034F-25ug 25μg
EUR 31.5

Mouse IgG3 Isotype Control (OC-515)
abx200593-100ug 100 ug
EUR 727.2

AF488 Mouse IgG3, κ Isotype Control
RD30028F-100Tests 100Tests
EUR 225

AF488 Mouse IgG3, κ Isotype Control
RD30028F-100Testsx2 100Testsx2
EUR 360

AF488 Mouse IgG3, κ Isotype Control
RD30028F-20Tests 20Tests
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AF647 Mouse IgG3, κ Isotype Control
RD30029F-100Tests 100Tests
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RD30029F-100Testsx2 100Testsx2
EUR 360

AF647 Mouse IgG3, κ Isotype Control
RD30029F-20Tests 20Tests
EUR 75

AF488 Mouse IgG3, κ Isotype Control
RD30039F-100ug 100μg
EUR 225

AF488 Mouse IgG3, κ Isotype Control
RD30039F-25ug 25μg
EUR 75

AF647 Mouse IgG3, κ Isotype Control
RD30040F-100ug 100μg
EUR 225

AF647 Mouse IgG3, κ Isotype Control
RD30040F-25ug 25μg
EUR 75

Mouse IgG3 Isotype Control (CF-Blue)
abx200592-100ug 100 ug
EUR 577.2

Biotin mouse IgG3, κ Isotype Control
E16FMCB005K-050U 50 μg
EUR 260
Description: Available in various conjugation types.

Biotin Mouse IgG3, κ Isotype Control
RD30033F-100ug 100μg
EUR 75

Biotin Mouse IgG3, κ Isotype Control
RD30033F-25ug 25μg
EUR 31.5

Purified mouse IgG3, κ Isotype Control
E16FMCK005K-050U 50 μg
EUR 411.67
Description: Available in various conjugation types.

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RD30032F-100ug 100μg
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Purified Mouse IgG3, κ Isotype Control
RD30032F-25ug 25μg
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Mouse IgG3 Isotype Control Antibody (B10)
MBS1564634-01mg 0.1mg
EUR 340

Mouse IgG3 Isotype Control Antibody (B10)
MBS1564634-5x01mg 5x0.1mg
EUR 1235

Mouse IgG3-PE conjugate (isotype control)
20102-104-PE 50 Tests
EUR 242.4

AFRed 780 Mouse IgG3, κ Isotype Control
RD30031F-100Tests 100Tests
EUR 225

AFRed 780 Mouse IgG3, κ Isotype Control
RD30031F-100Testsx2 100Testsx2
EUR 360

AFRed 780 Mouse IgG3, κ Isotype Control
RD30031F-20Tests 20Tests
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AFRed 780 Mouse IgG3, κ Isotype Control
RD30042F-100ug 100μg
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AFRed 780 Mouse IgG3, κ Isotype Control
RD30042F-25ug 25μg
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Mouse IgG3-HRP conjugate (isotype control)
20102-104-HP 50 Tests
EUR 196.8

Mouse IgG3-FITC conjugate (isotype control)
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AFViolet 450 Mouse IgG3, κ Isotype Control
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AFViolet 450 Mouse IgG3, κ Isotype Control
RD30041F-100ug 100μg
EUR 225

AFViolet 450 Mouse IgG3, κ Isotype Control
RD30041F-25ug 25μg
EUR 75

Mouse IgG3-Biotin conjugate (isotype control)
20102-104-B 50 Tests
EUR 196.8

NE Purified mouse IgG3, κ Isotype Control
E16FMCY005K-500U 500 μg
EUR 780
Description: Available in various conjugation types.

PE/Cyanine5 Mouse IgG3, κ Isotype Control
RD30026F-100Tests 100Tests
EUR 225

PE/Cyanine5 Mouse IgG3, κ Isotype Control
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EUR 360

PE/Cyanine5 Mouse IgG3, κ Isotype Control
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Mouse IgG3 Isotype Control Antibody (B1-8)
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Mouse IgG3 Isotype Control Antibody (B1-8)
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PerCP/Cyanine5.5 Mouse IgG3, κ Isotype Control
RD30027F-100Tests 100Tests
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PerCP/Cyanine5.5 Mouse IgG3, κ Isotype Control
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PerCP/Cyanine5.5 Mouse IgG3, κ Isotype Control
RD30038F-100ug 100μg
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RD30038F-25ug 25μg
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PE Mouse IgG3, κ Isotype Control[A112-3]
E-AB-F09752D-100Tests 100Tests
EUR 82
Description: FCM

PE Mouse IgG3, κ Isotype Control[A112-3]
E-AB-F09752D-100Tests2 100Tests×2
EUR 112
Description: FCM

PE Mouse IgG3, κ Isotype Control[A112-3]
E-AB-F09752D-20Tests 20Tests
EUR 32
Description: FCM

PE Mouse IgG3, κ Isotype Control[A112-3]
E-AB-F09753D-100ug 100ug
EUR 50
Description: FCM

PE Mouse IgG3, κ Isotype Control[A112-3]
E-AB-F09753D-25ug 25ug
EUR 21
Description: FCM

PE Mouse IgG3, κ Isotype Control[A112-3]
E-AB-F09753D-each each Ask for price
Description: FCM

Mouse IgG3 Isotype control (purified) validated fo
NG908 7 ml
EUR 245
Description: Mouse IgG3 Isotype control (purified) validated for IHC; Ready-To-Use

Mouse IgG3 Isotype control (purified) validated fo
NG908C 1 ml
EUR 285
Description: Mouse IgG3 Isotype control (purified) validated for IHC; Concentrate

APC Mouse IgG3, κ Isotype Control[A112-3]
E-AB-F09752E-100Tests 100Tests
EUR 110
Description: FCM

APC Mouse IgG3, κ Isotype Control[A112-3]
E-AB-F09752E-100Tests2 100Tests×2
EUR 160
Description: FCM

APC Mouse IgG3, κ Isotype Control[A112-3]
E-AB-F09752E-20Tests 20Tests
EUR 40
Description: FCM

APC Mouse IgG3, κ Isotype Control[A112-3]
E-AB-F09753E-100ug 100ug
EUR 69
Description: FCM

APC Mouse IgG3, κ Isotype Control[A112-3]
E-AB-F09753E-25ug 25ug
EUR 30
Description: FCM

APC Mouse IgG3, κ Isotype Control[A112-3]
E-AB-F09753E-each each Ask for price
Description: FCM

FITC Mouse IgG3, κ Isotype Control[A112-3]
E-AB-F09752C-100Tests 100Tests
EUR 82
Description: FCM

FITC Mouse IgG3, κ Isotype Control[A112-3]
E-AB-F09752C-100Tests2 100Tests×2
EUR 112
Description: FCM

FITC Mouse IgG3, κ Isotype Control[A112-3]
E-AB-F09752C-20Tests 20Tests
EUR 32
Description: FCM

FITC Mouse IgG3, κ Isotype Control[A112-3]
E-AB-F09753C-100ug 100ug
EUR 50
Description: FCM

FITC Mouse IgG3, κ Isotype Control[A112-3]
E-AB-F09753C-25ug 25ug
EUR 21
Description: FCM

FITC Mouse IgG3, κ Isotype Control[A112-3]
E-AB-F09753C-each each Ask for price
Description: FCM

Mouse IgG3, kappa Isotype Control Antibody (J606)
MBS1564635-01mg 0.1mg
EUR 340

Mouse IgG3, kappa Isotype Control Antibody (J606)
MBS1564635-5x01mg 5x0.1mg
EUR 1235

Human IgG3 Isotype Control
MBS378386-05mg 0.5mg
EUR 410

Human IgG3 Isotype Control
MBS378386-5x05mg 5x0.5mg
EUR 1550

Mouse IgG3-PE-Cy5 conjugate (isotype control)
20102-104-PC5 50 Tests
EUR 270

Biotin Mouse IgG3, κ Isotype Control[A112-3]
E-AB-F09753B-100ug 100ug
EUR 50
Description: FCM

Biotin Mouse IgG3, κ Isotype Control[A112-3]
E-AB-F09753B-25ug 25ug
EUR 21
Description: FCM

the similar is true for 19.0% (n = 6266) of variants of unknown medical significance or conflicting interpretation reported in the ClinVar database. The outcomes of the structural evaluation can be found in the devoted net catalogue Missense3D-DB. For every of the four M variants, the outcomes of the structural evaluation are introduced in a pleasant concise format that may be included in medical genetic stories. An in depth report of the structural evaluation can also be accessible for the non-experts in structural biology. Population frequency and predictions from SIFT and PolyPhen are included for a extra complete variant interpretation. This is the first large-scale atom-based structural interpretation of human genetic variation and presents geneticists and the biomedical neighborhood a new method to genetic variant interpretation.