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Protocol for the development of a repository of individual participant data from randomised controlled trials conducted in adult care homes (the Virtual International Care Homes Trials Archive (VICHTA))

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Protocol for the development of a repository of individual participant data from randomised controlled trials conducted in adult care homes (the Virtual International Care Homes Trials Archive (VICHTA))
Approximately 418,000 folks dwell in care homes in the UK, but accessible, sturdy data on care dwelling populations and organisation are missing. This hampers our means to plan, allocate assets or stop threat. Large randomised controlled trials (RCTs) conducted in care homes provide a potential resolution. The worth of detailed data on residents’ demographics, outcomes and contextual info captured in RCTs has but to be absolutely realised. Irrespective of the intervention examined, a lot of the trial data collected overlaps in phrases of structured assessments and descriptive info.
Given the time and prices required to prospectively accumulate data in these populations, pooling anonymised RCT data into a structured repository presents profit; secondary analyses of pooled RCT data can enhance understanding of this under-researched inhabitants and improve the future trial design. This protocol describes the creation of a project-specific repository of individual participant data (IPD) from trials conducted in care homes and subsequent enlargement into a legacy dataset for wider use, to deal with the want for correct, high-quality IPD on this susceptible inhabitants.
Informed by scoping of related literature, the principal investigators of RCTs conducted in adult care homes in the UK since 2010 will probably be invited to contribute trial IPD. Contributing trialists will type a Steering Committee who will oversee data sharing and stay gatekeepers of their very own trial’s data. IPD will probably be cleaned and standardised in session with the Steering Committee for accuracy. Planned analyses embrace a comparability of pooled IPD with level estimates from administrative sources, to evaluate generalisability of RCT data to the wider care dwelling inhabitants.
We may even establish key resident traits and outcomes from inside the trial repository, which is able to inform the development of a nationwide minimal dataset for care homes. Following challenge completion, administration will migrate to the Virtual Trials Archives, forming a legacy dataset which will probably be expanded to incorporate worldwide RCTs, and will probably be accessible to the wider analysis neighborhood for analyses. Analysis of pooled IPD has the potential to tell and direct future follow, analysis and coverage at low value, enhancing the worth of current data and lowering analysis waste. We intention to create a everlasting archive for care dwelling trial data and welcome the contribution of rising trial datasets.

OGP: A Repository of Experimentally Characterized O-Glycoproteins to Facilitate Studies on O-Glycosylation

Numerous research on most cancers, biopharmaceuticals, and medical trials have necessitated complete and exact evaluation of protein O-glycosylation. However, the lack of up to date and handy databases deters the storage of and reference to rising O-glycoprotein data. To resolve this difficulty, an O-glycoprotein repository named OGP was established in this work. It was constructed with a assortment of O-glycoprotein data from completely different sources. OGP accommodates 9354 O-glycosylation websites and 11,633 site-specific O-glycans mapping to 2133 O-glycoproteins, and it’s the largest O-glycoprotein repository to date. Based on the recorded O-glycosylation websites, an O-glycosylation web site prediction instrument was developed.

The first model of OGP repository and the web site enable customers to acquire numerous O-glycoprotein-related info, equivalent to protein accession numbers, O-glycosylation websites, glycopeptide sequences, site-specific glycan constructions, experimental strategies, and potential O-glycosylation websites. To tackle the challenges posed by large-scale development, validation, and adoption of synthetic intelligence (AI) in pathology, now we have constituted a consortium of teachers, small enterprises, and pharmaceutical corporations and proposed the BIGPICTURE challenge to the Innovative Medicines Initiative.

Our imaginative and prescient is to change into the catalyst in the digital transformation of pathology by creating the first European, ethically compliant, and quality-controlled entire slide imaging platform, in which each large-scale data and AI algorithms will exist. Our mission is to develop this platform in a sustainable and inclusive means, by connecting the neighborhood of pathologists, researchers, AI builders, sufferers, and trade events primarily based on creating worth and reciprocity in use primarily based on a neighborhood mannequin as the mechanism for making certain sustainability of the platform.

Protocol for the development of a repository of individual participant data from randomised controlled trials conducted in adult care homes (the Virtual International Care Homes Trials Archive (VICHTA))

Missense3D-DB net catalogue: an atom-based evaluation and repository of 4M human protein-coding genetic variants

The interpretation of human genetic variation is one of the biggest challenges of fashionable genetics. New approaches are urgently wanted to prioritize variants, particularly these which might be uncommon or lack a definitive medical interpretation. We examined 10,136,597 human missense genetic variants from GnomAD, ClinVar and UniProt. We had been capable of carry out large-scale atom-based mapping and phenotype interpretation of 3,960,015 of these variants onto 18,874 experimental and 84,818 in home predicted three-dimensional coordinates of the human proteome.

We show that 14% of amino acid substitutions from the GnomAD database that could possibly be structurally analysed are predicted to have an effect on protein construction (n = 568,548, of which 566,439 uncommon or extraordinarily uncommon) and will, subsequently, have a but unknown disease-causing impact. Moreover, an OGP-based web site is already accessible (http://www.oglyp.org/). The web site contains 4 specifically designed and user-friendly modules: statistical evaluation, database search, web site prediction, and data submission.

Mouse IgG3 Isotype Control (FITC)
abx405036-100tests 100 tests
EUR 510

Mouse IgG3 Isotype Control (PerCP)
abx200591-100ug 100 ug
EUR 878.4

Mouse IgG3 Isotype Control Purified
11-459-C025 0.025 mg
EUR 105.6

Mouse IgG3 Isotype Control Purified
11-459-C100 0.1 mg
EUR 163.2

Mouse IgG3 isotype control, purified
20102-104 100 ug
EUR 169.2

PE mouse IgG3, κ Isotype Control
E16FMCP005K-025U 25 μg
EUR 411.67
Description: Available in various conjugation types.

FITC mouse IgG3, κ Isotype Control
E16FMCF005K-050U 50 μg
EUR 325
Description: Available in various conjugation types.

Mouse IgG3 Isotype Control (OC-515)
abx200593-100ug 100 ug
EUR 727.2

Mouse IgG3 Isotype Control (CF-Blue)
abx200592-100ug 100 ug
EUR 577.2

Biotin mouse IgG3, κ Isotype Control
E16FMCB005K-050U 50 μg
EUR 260
Description: Available in various conjugation types.

Purified mouse IgG3, κ Isotype Control
E16FMCK005K-050U 50 μg
EUR 411.67
Description: Available in various conjugation types.

Mouse IgG3-PE conjugate (isotype control)
20102-104-PE 50 Tests
EUR 242.4

Mouse IgG3-HRP conjugate (isotype control)
20102-104-HP 50 Tests
EUR 196.8

Mouse IgG3-FITC conjugate (isotype control)
20102-104-F 50 tests
EUR 196.8

NE Purified mouse IgG3, κ Isotype Control
E16FMCY005K-500U 500 μg
EUR 780
Description: Available in various conjugation types.

Mouse IgG3-Biotin conjugate (isotype control)
20102-104-B 50 Tests
EUR 196.8

Mouse IgG3 Isotype control (purified) validated fo
NG908 7 ml
EUR 245
Description: Mouse IgG3 Isotype control (purified) validated for IHC; Ready-To-Use

Mouse IgG3 Isotype control (purified) validated fo
NG908C 1 ml
EUR 285
Description: Mouse IgG3 Isotype control (purified) validated for IHC; Concentrate

Mouse IgG3-PE-Cy5 conjugate (isotype control)
20102-104-PC5 50 Tests
EUR 270

Alexa Fluor® 488 mouse IgG3, κ Isotype Control
E16FMCG005K-100U 100 μg
EUR 845
Description: Available in various conjugation types.

Alexa Fluor® 647 mouse IgG3, κ Isotype Control
E16FMCK005K-025U 25 μg
EUR 173.33
Description: Available in various conjugation types.

Mouse IgG3 Isotype Control DyLight® 488
L4-459-C100 0.1 mg
EUR 255.6

Mouse IgG3 Isotype Control DyLight® 650
L6-459-C100 0.1 mg
EUR 255.6

OPRA03551-1MG - Mouse IgG3 Kappa (κ) isotype Control
OPRA03551-1MG 1mg
EUR 249

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PE
IMSIGG3KICA1123CPE100UG each
EUR 150
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PE

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PE
IMSIGG3KICA1123CPE25UG each
EUR 55
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PE

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 APC
IMSIGG3KICA1123CAPC100UG each
EUR 150
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 APC

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 APC
IMSIGG3KICA1123CAPC25UG each
EUR 55
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 APC

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 FITC
IMSIGG3KICA1123CFITC100UG each
EUR 150
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 FITC

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 FITC
IMSIGG3KICA1123CFITC25UG each
EUR 55
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 FITC

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 AF488
IMSIGG3KICA1123CAF488100UG each
EUR 150
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 AF488

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 AF488
IMSIGG3KICA1123CAF48825UG each
EUR 55
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 AF488

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 AF647
IMSIGG3KICA1123CAF647100UG each
EUR 150
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 AF647

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 AF647
IMSIGG3KICA1123CAF64725UG each
EUR 55
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 AF647

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 ER780
IMSIGG3KICA1123CER780100UG each
EUR 150
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 ER780

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 ER780
IMSIGG3KICA1123CER78025UG each
EUR 55
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 ER780

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 EV450
IMSIGG3KICA1123CEV450100UG each
EUR 150
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 EV450

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 EV450
IMSIGG3KICA1123CEV45025UG each
EUR 55
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 EV450

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 Biotin
IMSIGG3KICA1123CBL100UG each
EUR 150
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 Biotin

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 Biotin
IMSIGG3KICA1123CBL25UG each
EUR 55
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 Biotin

Mouse IgG1 Isotype Control
abx139001-01mg 0.1 mg
EUR 376.8

Mouse IgG1 Isotype Control
abx139002-01mg 0.1 mg
EUR 376.8

Mouse IgG1 Isotype Control
abx139008-01mg 0.1 mg
EUR 376.8

Mouse IgG1 Isotype Control
abx200564-100ug 100 ug
EUR 376.8

Mouse IgG1 Isotype Control
abx405007-01mg 0.1 mg
EUR 493.2

Mouse IgG1 Isotype Control
abx405009-05mg 0.5 mg
EUR 828

Mouse IgG1 Isotype Control
abx405012-1mg 1 mg
EUR 1296

Mouse IgG1 Isotype Control
abx405064-100tests 100 tests
EUR 493.2

Mouse IgG1 Isotype Control
abx405067-05mg 0.5 mg
EUR 994.8

Mouse IgG1 Isotype Control
E2790003 100ul
EUR 225
Description: Available in various conjugation types.

Mouse IgG1 Isotype Control
ICIGG1PU-01MG 100 tests
EUR 126.5

Mouse IgG2a Isotype Control
abx139004-01mg 0.1 mg
EUR 376.8

Mouse IgG2a Isotype Control
abx139005-01mg 0.1 mg
EUR 376.8

Mouse IgG2b Isotype Control
abx139006-01mg 0.1 mg
EUR 376.8

Mouse IgG2a Isotype Control
abx139009-01mg 0.1 mg
EUR 376.8

Mouse IgG2b Isotype Control
abx139011-01mg 0.1 mg
EUR 376.8

Mouse IgG2a Isotype Control
abx200572-100ug 100 ug
EUR 376.8

Mouse IgG2b Isotype Control
abx200580-100ug 100 ug
EUR 376.8

Mouse IgG2a Isotype Control
abx405013-100tests 100 tests
EUR 493.2

Mouse IgG2a Isotype Control
abx405015-05mg 0.5 mg
EUR 828

Mouse IgG2a Isotype Control
abx405018-1mg 1 mg
EUR 1328.4

Mouse IgG2b Isotype Control
abx405056-100tests 100 tests
EUR 493.2

Mouse IgG2b Isotype Control
abx405061-1mg 1 mg
EUR 1296

Mouse IgG2a Isotype Control
abx405070-100tests 100 tests
EUR 493.2

Mouse IgG2a Isotype Control
abx405073-05mg 0.5 mg
EUR 994.8

Mouse IgG2a Isotype Control
10R-I117d 1 mg
EUR 663.6
Description: Purified Mouse IgG2a Isotype Control

Mouse IgG2a Isotype Control
E2790004 100ul
EUR 225
Description: Available in various conjugation types.

Mouse IgG2b Isotype Control
E2790005 100ul
EUR 225
Description: Available in various conjugation types.

Mouse IgG Isotype Control
IC002-100ul 100ul
EUR 146.4

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PE/Cyanine5
IMSIGG3KICA1123CPECY5100UG each
EUR 150
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PE/Cyanine5

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PE/Cyanine5
IMSIGG3KICA1123CPECY525UG each
EUR 55
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PE/Cyanine5

Mouse IgG1 Isotype Control (PE)
abx139025-01mg 0.1 mg
EUR 510

Mouse IgG1 Isotype Control (PE)
abx200566-50ug 50 ug
EUR 510

Mouse IgG1 Isotype Control PE
1P-632-C025 0.025 mg
EUR 146.4

Mouse IgG1 Isotype Control PE
1P-632-C100 0.1 mg
EUR 244.8

Mouse IgG1 Isotype Control (PE)
E2790238 100ul
EUR 225
Description: Available in various conjugation types.

PE mouse IgG1 Isotype Control
E16FMCP001-050 50 tests
EUR 235.2
Description: Available in various conjugation types.

PE mouse IgG1 Isotype Control
E16FMCP001-100 100 Tests
EUR 336
Description: Available in various conjugation types.

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PerCP/Cyanine5.5
IMSIGG3KICA1123CPERCPCY55100UG each
EUR 150
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PerCP/Cyanine5.5

Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PerCP/Cyanine5.5
IMSIGG3KICA1123CPERCPCY5525UG each
EUR 55
Description: Mouse IgG3 Kappa Isotype Control Monoclonal Clone A1123 PerCP/Cyanine5.5

Mouse IgG1 Isotype Control (APC)
abx139022-01mg 0.1 mg
EUR 510

Mouse IgG1 Isotype Control (APC)
abx200567-50ug 50 ug
EUR 510

Mouse IgG1 Isotype Control (RPE)
abx405011-100tests 100 tests
EUR 760.8

Mouse IgG1 Isotype Control (APC)
abx405065-100tests 100 tests
EUR 493.2

Mouse IgG1 Isotype Control (RPE)
abx405069-100tests 100 tests
EUR 560.4

Mouse IgG1 Isotype Control APC
1A-632-C025 0.025 mg
EUR 146.4

Mouse IgG1 Isotype Control APC
1A-632-C100 0.1 mg
EUR 244.8

Mouse IgG1 Isotype Control (APC)
E2790221 100ul
EUR 225
Description: Available in various conjugation types.

APC mouse IgG1 Isotype Control
E16FMCA001-050 50 tests
EUR 268.67
Description: Available in various conjugation types.

APC mouse IgG1 Isotype Control
E16FMCA001-100 100 Tests
EUR 403.2
Description: Available in various conjugation types.

Mouse IgG1 Isotype Control (FITC)
abx139024-01mg 0.1 mg
EUR 460.8

Mouse IgG1 Isotype Control (FITC)
abx200565-100ug 100 ug
EUR 376.8

Mouse IgG1 Isotype Control (FITC)
abx405010-01mg 0.1 mg
EUR 610.8

Mouse IgG1 Isotype Control (FITC)
abx405068-100tests 100 tests
EUR 493.2

Mouse IgG1 Isotype Control FITC
1F-632-C025 0.025 mg
EUR 129.6

Mouse IgG1 Isotype Control FITC
1F-632-C100 0.1 mg
EUR 212.4

Mouse IgG1 Isotype Control (FITC)
E2790234 100ul
EUR 225
Description: Available in various conjugation types.

FITC mouse IgG1 Isotype Control
E16FMCF001-050 50 tests
EUR 168
Description: Available in various conjugation types.

FITC mouse IgG1 Isotype Control
E16FMCF001-100 100 Tests
EUR 268.8
Description: Available in various conjugation types.

Mouse IgG1 Isotype Control (PerCP)
abx139026-01mg 0.1 mg
EUR 560.4

Mouse IgG1 Isotype Control (PerCP)
abx200568-100ug 100 ug
EUR 510

Mouse IgG1 Isotype Control PerCP
PC-632-C025 0.025 mg
EUR 163.2

Mouse IgG1 Isotype Control PerCP
PC-632-C100 0.1 mg
EUR 277.2

Mouse IgG2a Isotype Control (PE)
abx139015-01mg 0.1 mg
EUR 510

Mouse IgG2b Isotype Control (PE)
abx139020-01mg 0.1 mg
EUR 510

Mouse IgG2a Isotype Control (PE)
abx200574-50ug 50 ug
EUR 510

Mouse IgG2b Isotype Control (PE)
abx200582-50ug 50 ug
EUR 510

Mouse IgG2b Isotype Control PE
1P-692-C025 0.025 mg
EUR 146.4

Mouse IgG2b Isotype Control PE
1P-692-C100 0.1 mg
EUR 244.8

Mouse IgG2a Isotype Control PE
1P-724-C025 0.025 mg
EUR 146.4

Mouse IgG2a Isotype Control PE
1P-724-C100 0.1 mg
EUR 244.8

Mouse IgG2a Isotype Control (PE)
E2790239 100ul
EUR 225
Description: Available in various conjugation types.

Mouse IgG2b Isotype Control (PE)
E2790240 100ul
EUR 225
Description: Available in various conjugation types.

PE mouse IgG2a Isotype Control
E16FMCP002-050 50 tests
EUR 235.2
Description: Available in various conjugation types.

PE mouse IgG2a Isotype Control
E16FMCP002-100 100 Tests
EUR 336
Description: Available in various conjugation types.

PE mouse IgG2b Isotype Control
E16FMCP003-050 50 tests
EUR 235.2
Description: Available in various conjugation types.

PE mouse IgG2b Isotype Control
E16FMCP003-100 100 Tests
EUR 336
Description: Available in various conjugation types.

Mouse IgG1 Isotype Control (Biotin)
abx139023-01mg 0.1 mg
EUR 460.8

Mouse IgG1 Isotype Control (Biotin)
abx405008-01mg 0.1 mg
EUR 610.8

Mouse IgG1 Isotype Control (Biotin)
abx405066-100tests 100 tests
EUR 493.2

Mouse IgG1 Isotype Control Biotin
1B-632-C025 0.025 mg
EUR 129.6

Mouse IgG1 Isotype Control Biotin
1B-632-C100 0.1 mg
EUR 212.4

Biotin mouse IgG1 Isotype Control
E16FMCB001-050 50 tests
EUR 168
Description: Available in various conjugation types.

Biotin mouse IgG1 Isotype Control
E16FMCB001-100 100 Tests
EUR 268.8
Description: Available in various conjugation types.

Biotin mouse IgG1 Isotype Control
E16FMCB001-100U 100 μg
EUR 268.8
Description: Available in various conjugation types.

Biotin mouse IgG1 Isotype Control
E16FMCB001-500U 500 μg
EUR 739.2
Description: Available in various conjugation types.

Mouse IgG2a Isotype Control (APC)
abx139012-01mg 0.1 mg
EUR 510

Mouse IgG2b Isotype Control (APC)
abx139017-01mg 0.1 mg
EUR 510

Mouse IgG2a Isotype Control (APC)
abx200575-50ug 50 ug
EUR 510

Mouse IgG2b Isotype Control (APC)
abx200583-50ug 50 ug
EUR 510

Mouse IgG2a Isotype Control (RPE)
abx405017-100tests 100 tests
EUR 760.8

Mouse IgG2b Isotype Control (APC)
abx405057-100tests 100 tests
EUR 577.2

the similar is true for 19.0% (n = 6266) of variants of unknown medical significance or conflicting interpretation reported in the ClinVar database. The outcomes of the structural evaluation can be found in the devoted net catalogue Missense3D-DB. For every of the four M variants, the outcomes of the structural evaluation are introduced in a pleasant concise format that may be included in medical genetic stories. An in depth report of the structural evaluation can also be accessible for the non-experts in structural biology. Population frequency and predictions from SIFT and PolyPhen are included for a extra complete variant interpretation. This is the first large-scale atom-based structural interpretation of human genetic variation and presents geneticists and the biomedical neighborhood a new method to genetic variant interpretation.